Podcast
Questions and Answers
What type of influenza virus is known for infecting multiple species, including humans, swine, equines, and birds?
What type of influenza virus is known for infecting multiple species, including humans, swine, equines, and birds?
- Influenza A (correct)
- Influenza B
- Influenza C
- Influenza D
Which surface protein is primarily associated with the virion envelope of influenza?
Which surface protein is primarily associated with the virion envelope of influenza?
- Nucleoprotein
- Fusion protein
- Glycoprotein
- Hemagglutinin (HA) (correct)
Which of the following describes the process of antigenic DRIFT?
Which of the following describes the process of antigenic DRIFT?
- Sudden mutations due to environmental stress
- Major changes in HA or NA resulting in novel subtypes
- Gradual amino acid substitutions causing smaller outbreaks (correct)
- Complete genetic reassortment between viruses
Which vaccine formulation is recommended for a quadrivalent influenza vaccine that is also egg-free?
Which vaccine formulation is recommended for a quadrivalent influenza vaccine that is also egg-free?
Which population is specifically contraindicated for the use of the Live Attenuated Influenza Vaccine (LAIV)?
Which population is specifically contraindicated for the use of the Live Attenuated Influenza Vaccine (LAIV)?
What is the primary cause of antigenic variation in influenza viruses?
What is the primary cause of antigenic variation in influenza viruses?
What differentiates antigenic SHIFT from antigenic DRIFT in influenza viruses?
What differentiates antigenic SHIFT from antigenic DRIFT in influenza viruses?
What type of influenza virus primarily causes major pandemics due to its susceptibility to antigenic variation?
What type of influenza virus primarily causes major pandemics due to its susceptibility to antigenic variation?
Which groups are considered at high risk for influenza complications, warranting specific vaccination recommendations?
Which groups are considered at high risk for influenza complications, warranting specific vaccination recommendations?
What is the recommended timing for initiating antiviral treatment for influenza to ensure maximum clinical benefit?
What is the recommended timing for initiating antiviral treatment for influenza to ensure maximum clinical benefit?
Which antiviral drug is NOT classified as a neuraminidase inhibitor (NA inhibitor)?
Which antiviral drug is NOT classified as a neuraminidase inhibitor (NA inhibitor)?
What is the minimum age at which annual influenza vaccination is recommended?
What is the minimum age at which annual influenza vaccination is recommended?
Which of the following scenarios warrants the use of pre-exposure chemoprophylaxis for influenza?
Which of the following scenarios warrants the use of pre-exposure chemoprophylaxis for influenza?
Which factors contribute to a child aged 2-4 years being considered for increased influenza risk?
Which factors contribute to a child aged 2-4 years being considered for increased influenza risk?
In the clinical prediction rule for diagnosing influenza, how many points are assigned for myalgias?
In the clinical prediction rule for diagnosing influenza, how many points are assigned for myalgias?
Which method is preferred for the prevention of influenza in general?
Which method is preferred for the prevention of influenza in general?
What is the recommended interval for giving the inactivated influenza vaccine to children aged 6 months to 8 years?
What is the recommended interval for giving the inactivated influenza vaccine to children aged 6 months to 8 years?
Is routine widespread chemoprophylaxis with antivirals recommended outside of institutional outbreaks?
Is routine widespread chemoprophylaxis with antivirals recommended outside of institutional outbreaks?
Which symptom combination yields the highest points in the clinical prediction rule for diagnosing influenza?
Which symptom combination yields the highest points in the clinical prediction rule for diagnosing influenza?
What is the maximum time frame within which antiviral treatment should ideally be initiated for influenza to ensure clinical benefit?
What is the maximum time frame within which antiviral treatment should ideally be initiated for influenza to ensure clinical benefit?
Which antiviral drug is categorized as a Cap dependent endonuclear inhibitor?
Which antiviral drug is categorized as a Cap dependent endonuclear inhibitor?
What should be the approach towards chemoprophylaxis with NA inhibitors for patients?
What should be the approach towards chemoprophylaxis with NA inhibitors for patients?
Which of the following populations is NOT indicated for post-exposure chemoprophylaxis?
Which of the following populations is NOT indicated for post-exposure chemoprophylaxis?
Which treatment is preferred for influenza in pregnant women?
Which treatment is preferred for influenza in pregnant women?
For children aged 6 months to 8 years, how many doses of inactivated influenza vaccine are recommended?
For children aged 6 months to 8 years, how many doses of inactivated influenza vaccine are recommended?
Which of the following statements about routine widespread chemoprophylaxis for antiviral drugs is accurate?
Which of the following statements about routine widespread chemoprophylaxis for antiviral drugs is accurate?
What type of influenza virus is most associated with significant changes that create novel subtypes capable of causing widespread pandemics?
What type of influenza virus is most associated with significant changes that create novel subtypes capable of causing widespread pandemics?
Who among the following is considered eligible for pre-exposure chemoprophylaxis?
Who among the following is considered eligible for pre-exposure chemoprophylaxis?
Which age group is advised to receive annual influenza vaccination?
Which age group is advised to receive annual influenza vaccination?
What are the two mechanisms of antigenic variation in influenza viruses?
What are the two mechanisms of antigenic variation in influenza viruses?
Which protein on the surface of the influenza virion envelope is primarily responsible for facilitating viral entry into host cells?
Which protein on the surface of the influenza virion envelope is primarily responsible for facilitating viral entry into host cells?
Which statement accurately describes antigenic drift in influenza viruses?
Which statement accurately describes antigenic drift in influenza viruses?
In which type of population is the Live Attenuated Influenza Vaccine (LAIV) contraindicated?
In which type of population is the Live Attenuated Influenza Vaccine (LAIV) contraindicated?
Which influenza vaccine formulation is suitable for individuals who require an egg-free option?
Which influenza vaccine formulation is suitable for individuals who require an egg-free option?
What is the recommended strategy for influenza vaccination for healthy individuals over six months of age?
What is the recommended strategy for influenza vaccination for healthy individuals over six months of age?
What characterizes antigenic shift in the context of influenza viruses?
What characterizes antigenic shift in the context of influenza viruses?
Flashcards
Influenza Viruses
Influenza Viruses
RNA viruses belonging to the Orthomyxoviridae family that infect humans, swine, equines, and birds.
Types of Influenza Viruses
Types of Influenza Viruses
Influenza viruses, classified into three types: A, B, and C, with type A having the widest host range.
Antigenic Variation
Antigenic Variation
Changes in surface proteins (hemagglutinin (HA) and neuraminidase (NA)) of influenza viruses, leading to variations in the virus's ability to evade the immune system.
Antigenic Drift
Antigenic Drift
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Antigenic Shift
Antigenic Shift
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Influenza Vaccination
Influenza Vaccination
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Inactivated Influenza Vaccine (IIV)
Inactivated Influenza Vaccine (IIV)
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Recombinant Inactivated Vaccine (RIV)
Recombinant Inactivated Vaccine (RIV)
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Live Attenuated Influenza Vaccine (LAIV)
Live Attenuated Influenza Vaccine (LAIV)
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Contraindications for LAIV
Contraindications for LAIV
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Quadrivalent Influenza Vaccine
Quadrivalent Influenza Vaccine
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IIV Preference for Vaccination
IIV Preference for Vaccination
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Children's Influenza Vaccine Dosing
Children's Influenza Vaccine Dosing
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Clinical Prediction Rule for Influenza
Clinical Prediction Rule for Influenza
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Antiviral Treatment for Influenza
Antiviral Treatment for Influenza
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Oseltamivir (Tamiflu)
Oseltamivir (Tamiflu)
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Zanamivir (Relenza)
Zanamivir (Relenza)
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Peramivir
Peramivir
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Baloxavir Marboxil (Xofluza)
Baloxavir Marboxil (Xofluza)
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Chemoprophylaxis for Influenza
Chemoprophylaxis for Influenza
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Pre-exposure Prophylaxis
Pre-exposure Prophylaxis
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Post-exposure Prophylaxis
Post-exposure Prophylaxis
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Vaccination for Influenza Prevention
Vaccination for Influenza Prevention
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Influenza Treatment During Pregnancy
Influenza Treatment During Pregnancy
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Antiviral Chemoprophylaxis Limitations
Antiviral Chemoprophylaxis Limitations
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Study Notes
Influenza Overview
- Influenza viruses are RNA viruses belonging to the Orthomyxoviridae family.
- Three types infect humans: Influenza A, B, and C.
- Influenza A has the broadest host range, infecting humans, swine, equines, and birds.
Antigenic Variation
- Antigenic variation in influenza arises from changes in hemagglutinin (HA) and neuraminidase (NA) surface proteins.
- Two types of antigenic variation:
- Antigenic Drift: Small, gradual amino acid changes leading to minor outbreaks.
- Antigenic Shift: Major changes resulting in novel subtypes that can cause pandemics.
Vaccination Recommendations
- Annual influenza vaccination is advised for everyone aged six months and older without contraindications.
- Vaccination options include:
- Inactivated Influenza Vaccines (IIV)
- Recombinant Inactivated Vaccine (RIV)
- Live Attenuated Influenza Vaccine (LAIV), contraindicated in pregnant individuals and specific high-risk populations.
- Quadrivalent vaccines are egg-free.
Vaccine Administration
- IIV preferred over LAIV for vaccination.
- Children aged 6 months to 8 years need two doses of IIV, spaced at least four weeks apart.
Clinical Prediction and Treatment
- A symptom-based clinical prediction rule assists in diagnosing influenza with point assignments for fever, cough, myalgias, and early symptom onset.
- Antiviral treatments are effective if initiated within 24 hours of symptom onset.
- Approved antiviral drugs include:
- Oseltamivir (NA inhibitor)
- Zanamivir (NA inhibitor)
- Peramivir (NA inhibitor)
- Baloxavir (Cap-dependent endonuclease inhibitor)
Chemoprophylaxis Guidelines
- Chemoprophylaxis with NA inhibitors is not universally recommended, only for specific high-risk populations.
- Pre-exposure prophylaxis is suitable for individuals with immune deficiencies or those in close contact with at-risk populations.
- Post-exposure prophylaxis should be initiated within 48 hours of exposure to influenza, especially for unvaccinated high-risk individuals.
Preferred Treatment and Prevention
- Vaccination remains the primary method for preventing influenza.
- Oral Oseltamivir is the preferred treatment for influenza during pregnancy.
- Antivirals should not be used for routine chemoprophylaxis outside of outbreaks.
Influenza Overview
- Influenza viruses are RNA viruses belonging to the Orthomyxoviridae family.
- Three types infect humans: Influenza A, B, and C.
- Influenza A has the broadest host range, infecting humans, swine, equines, and birds.
Antigenic Variation
- Antigenic variation in influenza arises from changes in hemagglutinin (HA) and neuraminidase (NA) surface proteins.
- Two types of antigenic variation:
- Antigenic Drift: Small, gradual amino acid changes leading to minor outbreaks.
- Antigenic Shift: Major changes resulting in novel subtypes that can cause pandemics.
Vaccination Recommendations
- Annual influenza vaccination is advised for everyone aged six months and older without contraindications.
- Vaccination options include:
- Inactivated Influenza Vaccines (IIV)
- Recombinant Inactivated Vaccine (RIV)
- Live Attenuated Influenza Vaccine (LAIV), contraindicated in pregnant individuals and specific high-risk populations.
- Quadrivalent vaccines are egg-free.
Vaccine Administration
- IIV preferred over LAIV for vaccination.
- Children aged 6 months to 8 years need two doses of IIV, spaced at least four weeks apart.
Clinical Prediction and Treatment
- A symptom-based clinical prediction rule assists in diagnosing influenza with point assignments for fever, cough, myalgias, and early symptom onset.
- Antiviral treatments are effective if initiated within 24 hours of symptom onset.
- Approved antiviral drugs include:
- Oseltamivir (NA inhibitor)
- Zanamivir (NA inhibitor)
- Peramivir (NA inhibitor)
- Baloxavir (Cap-dependent endonuclease inhibitor)
Chemoprophylaxis Guidelines
- Chemoprophylaxis with NA inhibitors is not universally recommended, only for specific high-risk populations.
- Pre-exposure prophylaxis is suitable for individuals with immune deficiencies or those in close contact with at-risk populations.
- Post-exposure prophylaxis should be initiated within 48 hours of exposure to influenza, especially for unvaccinated high-risk individuals.
Preferred Treatment and Prevention
- Vaccination remains the primary method for preventing influenza.
- Oral Oseltamivir is the preferred treatment for influenza during pregnancy.
- Antivirals should not be used for routine chemoprophylaxis outside of outbreaks.
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