Lecture 03: Inflammatory Response Overview [MCQ 1

<p>Vasodilation and increased capillary permeability (C)</p> Signup and view all the answers

<p>Attract immune cells to the site of injury (A)</p> Signup and view all the answers

<p>Numbness (A)</p> Signup and view all the answers

<p>Innate immune cells initiate the inflammatory response, and adaptive immune cells provide a more specific and long-lasting response. (A)</p> Signup and view all the answers

<p>The movement of immune cells from the blood into the tissues (C)</p> Signup and view all the answers

<p>Recognition of pathogen-associated molecular patterns (PAMPS) by pattern recognition receptors (PRRs) (B)</p> Signup and view all the answers

<p>Type of pathogen involved (D)</p> Signup and view all the answers

<p>Directly triggering the production of proinflammatory cytokines like TNF? (D)</p> Signup and view all the answers

<p>Integrins initially bind weakly to ICAMs, but their high affinity is induced by chemokines. (A)</p> Signup and view all the answers

<p>They are typically large proteins that require specific receptors on target cells. (C)</p> Signup and view all the answers

<p>It acts as a chemoattractant, recruiting neutrophils to sites of infection. (B)</p> Signup and view all the answers

<p>Integrins are involved in the firm adhesion of leukocytes to the endothelium, preparing them for diapedesis. (C)</p> Signup and view all the answers

<p>CC chemokines primarily attract monocytes and macrophages, while CXC chemokines attract neutrophils. (A)</p> Signup and view all the answers

<p>Chemokines are released in higher concentrations at the site of inflammation, creating a gradient that attracts leukocytes. (C)</p> Signup and view all the answers

<p>TNF is a type of cytokine that primarily functions as a chemoattractant for neutrophils. (A)</p> Signup and view all the answers

<p>Cytokines primarily influence gene expression, while chemokines are primarily involved in altering cell movement and adhesion. (D)</p> Signup and view all the answers

<p>Direct activation of T lymphocytes to produce antibodies that target invading pathogens. (B)</p> Signup and view all the answers

The process where cytokines trigger endothelial cells to express ICAMs.

Signaling proteins that induce leukocytes to express high affinity integrins.

The process of leukocytes crossing through broken endothelial junctions into tissues.

Proteins that mediate communication between cells, affecting adhesion and survival.

A proinflammatory cytokine released by macrophages and epithelial cells.

A proinflammatory cytokine released by macrophages and neutrophils that binds to TNF receptors.

A chemokine that recruits and activates neutrophils during infections.

The process by which leukocytes engulf and clear pathogens or dead cells.

Types of chemokines that attract different immune cells: CXC attracts neutrophils and CC attracts monocytes/macrophages.

The ability of leukocytes to firmly adhere to endothelial cells during the immune response.

A complex response to infection, involving redness, heat, swelling, and pain.

Redness, swelling, pain, and heat observed during inflammation.

Most abundant white blood cells, first responders to infection, dying after about 8 hours.

Resident cells that are the first to encounter microbes, involved in phagocytosis.

Tissue-resident cells that sense danger and release cytokines to activate the immune response.

Cells in skin and mucosal tissues that release histamine and cytokines in response to allergens.

The process by which immune cells release signaling molecules to communicate during inflammation.

Widening of blood vessels during inflammation to increase blood flow and immune cell access.

The process where immune cells exit blood vessels to reach the injury site.

Types of cytokines involved in inflammation, promoting immune response.