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Questions and Answers
What is the primary role of the epidermis in the skin?
What is the primary role of the epidermis in the skin?
Which phase of wound healing involves the formation of granulation tissue?
Which phase of wound healing involves the formation of granulation tissue?
Which layer of the skin is responsible for the sensations of heat and touch?
Which layer of the skin is responsible for the sensations of heat and touch?
What is the main function of the basement membrane?
What is the main function of the basement membrane?
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What occurs during the hemostasis phase of wound healing?
What occurs during the hemostasis phase of wound healing?
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What is NOT one of the main functions of the skin?
What is NOT one of the main functions of the skin?
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What type of collagen is most dominant in scar tissue after wound healing?
What type of collagen is most dominant in scar tissue after wound healing?
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What best describes granulation tissue?
What best describes granulation tissue?
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What is the primary cause of trench foot?
What is the primary cause of trench foot?
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Which type of frostbite involves cold, hard, wooden skin?
Which type of frostbite involves cold, hard, wooden skin?
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What complication arises from the combination of ice crystal formation and microvascular occlusion in frostbite?
What complication arises from the combination of ice crystal formation and microvascular occlusion in frostbite?
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Which group is most commonly affected by immersion foot?
Which group is most commonly affected by immersion foot?
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What should be done immediately for a patient suspected of having frostbite?
What should be done immediately for a patient suspected of having frostbite?
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What is the primary reason that treatment for environmental soft tissue injuries is often inadequate?
What is the primary reason that treatment for environmental soft tissue injuries is often inadequate?
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In which stage of injury is the area likely to have a crater-like appearance due to damage beneath the skin?
In which stage of injury is the area likely to have a crater-like appearance due to damage beneath the skin?
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Which of the following best describes frostnip?
Which of the following best describes frostnip?
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What is a significant physiological risk factor for environmental soft tissue injuries?
What is a significant physiological risk factor for environmental soft tissue injuries?
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Which skin condition is primarily associated with repeated exposure to cold and wet environments?
Which skin condition is primarily associated with repeated exposure to cold and wet environments?
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Which stage of injury presents the highest risk of severe complications like infection?
Which stage of injury presents the highest risk of severe complications like infection?
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What typical characteristics define non-freezing cold injuries (NFCIs)?
What typical characteristics define non-freezing cold injuries (NFCIs)?
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Who is at the greatest risk of environmental soft tissue injuries?
Who is at the greatest risk of environmental soft tissue injuries?
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What is a characteristic of closed wounds?
What is a characteristic of closed wounds?
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Which type of wound is caused by a sharp or pointed object?
Which type of wound is caused by a sharp or pointed object?
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What defines a Class IV surgical wound?
What defines a Class IV surgical wound?
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Why should never an impaled object be removed?
Why should never an impaled object be removed?
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What injury result involves full thickness skin loss with non-approximatable edges?
What injury result involves full thickness skin loss with non-approximatable edges?
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Which of the following is a sign that a wound may require hospital treatment?
Which of the following is a sign that a wound may require hospital treatment?
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What type of wound is characterized by a combination of puncture and crush injury?
What type of wound is characterized by a combination of puncture and crush injury?
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What is a primary risk factor for Class III contaminated wounds?
What is a primary risk factor for Class III contaminated wounds?
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What characteristic is typical of hematomas?
What characteristic is typical of hematomas?
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Which of these is typically associated with a gunshot wound?
Which of these is typically associated with a gunshot wound?
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What is the primary purpose of inflammation in response to injury?
What is the primary purpose of inflammation in response to injury?
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Which phase occurs first in the inflammatory response?
Which phase occurs first in the inflammatory response?
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Passive immunity in neonates is primarily derived from which source?
Passive immunity in neonates is primarily derived from which source?
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Which type of immunity involves antibodies produced within the individual's own body?
Which type of immunity involves antibodies produced within the individual's own body?
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What are antibodies produced by in the immune system?
What are antibodies produced by in the immune system?
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What does the Complement System enhance in the immune response?
What does the Complement System enhance in the immune response?
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Which antibody is most commonly found in the body?
Which antibody is most commonly found in the body?
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During which phase of inflammation does tissue rebuilding occur?
During which phase of inflammation does tissue rebuilding occur?
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In cell-mediated immunity, which type of cells primarily identifies and attacks infected cells?
In cell-mediated immunity, which type of cells primarily identifies and attacks infected cells?
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Which of the following is a characteristic sign of inflammation?
Which of the following is a characteristic sign of inflammation?
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Study Notes
Inflammatory Response
- Inflammation is an adaptive mechanism to disease or injury, but may cause negative effects if excessive or prolonged.
- Its primary function is to contain and eliminate injurious agents while facilitating blood flow and immune cell access to the affected site.
- Triggers for inflammation include physical injuries (cuts, extreme temperatures), chemical exposure (acids and bases), ischemia, allergies, and infections.
- Inflammation progresses through three basic stages:
- Acute Phase: Vasodilation increases blood flow; macrophages engulf pathogens.
- Proliferation Phase: Tissue rebuilding with collagen by fibroblasts.
- Remodeling Phase: Strengthening of repaired tissue.
- Classic signs of inflammation include redness, swelling, pain, and warmth.
Immune Response
- Immune responses are categorized into natural/passive immunity and acquired humoral immunity.
- Passive immunity involves antibodies produced in another organism, such as maternal antibodies transferred during pregnancy.
- Acquired immunity arises from direct exposure to pathogens or through vaccination.
- Antibodies (IgG, IgM, IgA, IgD, IgE) are proteins produced by B-cells to fight specific pathogens, binding to antigens to promote their destruction.
- IgG is the most common antibody; IgE is linked to allergic reactions.
- Antigens trigger immune responses and can be harmful pathogens or non-pathogenic allergens.
- The complement system enhances antibody and phagocyte function but does not adapt over time like antibodies.
- Cell-mediated immunity is primarily facilitated by T-cells, which detect and eliminate infected or abnormal cells.
Anatomy of the Skin
- The integumentary system is the body's outermost organ layer, comprising the skin and auxiliary structures (hair, nails).
- Skin represents 12-15% of total body weight and serves three main functions: protection, regulation, and sensation.
- The epidermis is the outer barrier; the basement membrane separates it from the dermis, containing cytokines and growth factors.
- The dermis houses connective tissue and sensory receptors, while the subcutaneous layer connects skin to underlying tissues.
- The skin provides a physical barrier, regulates temperature and water balance, and contains sensory receptors for touch, pain, and temperature.
Soft Tissue Injuries & Healing Process
- Wounds disrupt tissue integrity; deeper injuries that reach muscle or organs are termed complicated wounds.
- Phases of wound healing include:
- Hemostasis: Clot formation via blood vessel constriction and platelet aggregation.
- Inflammation: Chemical mediators induce swelling, controlling bleeding and preventing infection.
- Proliferation: Collagen deposition and granulation tissue formation promote tissue repair.
- Remodeling: Collagen type transitions occur, finalizing skin repair with scarring.
Wound Classification
- Closed wounds arise from blunt trauma, typically involve less external bleeding:
- Contusions involve vessel disruption beneath the epidermis.
- Hematomas are blood collections under the skin.
- Abrasions are partial thickness injuries with skin scraping.
- Open wounds result from blunt or penetrating trauma, often with significant bleeding or risk of infection:
- Lacerations are skin tears or splits.
- Punctures occur from sharp objects; avoid removing impaled objects unless necessary.
- Gunshot wounds may present unpredictably; assess entrance and exit.
- Injection injuries introduce substances into the body.
- Avulsions result in full-thickness skin loss, often in extremities.
- Degloving injuries involve skin detachment from underlying tissue.
- Amputations are complete or partial limb losses.
- Bites may present various injury types and have high infection risk.
Surgical Wound Classifications
- Wounds are classified based on infection risk:
- Class I (Clean): No infection signs; closed wounds.
- Class II (Clean-Contaminated): Clean with organ entry but no significant spillage.
- Class III (Contaminated): Open wounds with visible contamination.
- Class IV (Dirty/Infected): Open wounds, potentially infected with debris.
Wounds Requiring Hospital Treatment
- Significant wounds include:
- Depth over 6mm/0.25in or length over 19mm/0.75in, especially with jagged edges.
- Deep wounds involving fat, muscle, or bone.
- Wounds over a joint may require surgical intervention for proper healing.
- Important care strategies include routine repositioning, skin care, and nutrition support to prevent complications.
Environmental Soft Tissue Injuries
- Two categories: Non-freezing cold injuries (NFCI) and frostbite, with frostbite being more severe.
- NFCIs can cause significant disability; common in adults aged 30-49 due to behavioral risk factors.
- Frostnip is the mildest form, resulting from prolonged cold exposure without freezing.
- Chilblains develop due to repeated exposure to cold and wet conditions, leading to tissue damage.
- Trench foot arises from extended wet conditions causing tissue edema and possible injury.
- Frostbite manifests severe tissue loss and risks long-term disability; treatment should focus on warming and revascularization.
Frostbite Assessment
- Skin appearance ranges from mild blanching in frostnip to hard, necrotic skin in deep frostbite.
- Immediate action includes removing the patient from cold environments and monitoring for signs of severe cold exposure and internal injury.
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