Inflammation and Healing Quiz

Inflammation and Healing

• Tears are a first line of defense
• Specific body defenses include sensitised T lymphocytes
• Inflammation is a nonspecific response to tissue injury
• Chemical mediators released during inflammation include histamine and prostaglandins
• Prolongation of inflammation is mediated by resolvins
• Granulation tissue is highly vascular, fragile, and susceptible to infection
• Edema is caused by increased fluid and protein in the interstitial compartment
• Inflammation leads to warmth and redness due to increased blood flow
• Inflammatory response events (in order after tissue injury): Vasoconstriction, Dilation of blood vessels, Increased permeability of blood vessels, Migration of leukocytes, Hyperemia
• Phagocytosis involves leukocytes ingesting foreign material and cell debris
• Severe inflammation leads to systemic effects like fatigue, anorexia, and mild fever
• Leukocytosis means increased white blood cells
• Glucocorticoids decrease capillary permeability
• Burns are classified by depth (first, superficial, deep partial, and full thickness)
• A full-thickness burn appears dry, firm, charred, or hard
• Infection in burn areas may originate from microbes surviving in hair follicles
• Large burns cause decreased blood pressure due to fluid and protein shift out of capillaries
• Inflammatory response aims to remove damaged materials and promote healing
• Inflammatory responses can be systemic or local
• Healing involves replacement of damaged cells or scar tissue formation
• Resolution, regeneration, and repair are aspects of healing
• Factors that promote healing include excellent nutrition, and no damage to the area
• Damaged tissues can be regenerated or repaired through scar tissue
• Inflammation can be caused by several factors, including physical damage, allergies, or infections
• Systemic manifestation of inflammation include pyrexia, malaise, and anorexia

Chemical Mediators

• Chemical mediators released during inflammation include histamine and prostaglandins

Inflammation Response

• Initial inflammatory response involves vasoconstriction followed by vasodilation increasing blood flow to the area
• Inflammation involves local changes like swelling, warmth, and pain; there are also systemic symptoms
• Key cell types involved include neutrophils, macrophages, basophils, and mast cells

Wound Healing

• Resolution is tissue recovery with minimal damage
• Regeneration is cell replacement via mitosis
• Scar tissue forms if cells cannot regenerate
• Granulation tissue forms as part of wound healing
• Blood clots and cell debris removal are initial steps
• Phagocytes are crucial for material removal and promoting healing.

Burn Classification

• Different burn types exist (e.g., first-degree, second-degree, third-degree) based on the tissue layers damaged
• Full-thickness burns involve damage to all skin layers.

Test your knowledge on the mechanisms of inflammation and healing processes in the body. This quiz covers the physiological responses to tissue injury, the role of chemical mediators, and the various stages of the inflammatory response. Understand how the body defends itself and the implications of prolonged inflammation.