Infective Endocarditis باطنية
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Questions and Answers

What are common clinical manifestations of acute endocarditis?

Severe febrile illness, changing heart murmurs, and petechiae are common manifestations.

How does partially treated acute endocarditis differ from subacute endocarditis?

Partially treated acute endocarditis exhibits similar characteristics to subacute endocarditis in its clinical presentation.

What is the role of echocardiography in diagnosing endocarditis?

Echocardiography can detect abscesses and vegetations associated with endocarditis.

What is the indication for antibiotic prophylaxis in patients at risk of infective endocarditis?

<p>Antibiotic prophylaxis is indicated for individuals with a prosthetic cardiac valve and a history of infective endocarditis.</p> Signup and view all the answers

What are the indications for cardiac surgery in the context of infective endocarditis?

<p>Indications include heart failure from valve damage and persistent infection despite antibiotic therapy.</p> Signup and view all the answers

List two organisms that can cause endocarditis, particularly in a post-operative scenario.

<p>Staphylococcus and Enterococcus are commonly associated with post-operative endocarditis.</p> Signup and view all the answers

What are common findings on an ECG for patients with suspected endocarditis?

<p>The ECG may show AV block and infarction related to embolic events.</p> Signup and view all the answers

What empirical treatment is advised for acute endocarditis before the identification of the organism?

<p>Empirical treatment for acute endocarditis should include vancomycin and gentamicin.</p> Signup and view all the answers

What is the significance of the minimum inhibitory concentration (MIC) in endocarditis management?

<p>Determining the MIC helps guide targeted antibiotic therapy against the identified organism.</p> Signup and view all the answers

Can chronic endocarditis present with clinical stigmata during the examination?

<p>Chronic endocarditis usually does not present with clinical stigmata.</p> Signup and view all the answers

What is infective endocarditis and what are its common causes?

<p>Infective endocarditis is a microbial infection of a heart valve or cardiac chamber. Common causes include streptococci, staphylococci, and Enterococcus species, often entering the bloodstream during dental procedures or from the bowel.</p> Signup and view all the answers

What are the epidemiological statistics regarding infective endocarditis related to cardiac abnormalities?

<p>Infective endocarditis affects approximately 5 to 15 cases per 100,000 per annum, with cardiac abnormalities accounting for 25% of cases.</p> Signup and view all the answers

How do viridans streptococci contribute to infective endocarditis?

<p>Viridans streptococci, like Streptococcus mitis, enter the bloodstream during activities such as tooth-brushing and are a common cause of subacute endocarditis.</p> Signup and view all the answers

What distinguishes acute endocarditis from subacute endocarditis?

<p>Acute endocarditis presents rapidly and is often caused by aggressive organisms like Staphylococcus aureus, whereas subacute endocarditis develops more insidiously, typically with less aggressive organisms.</p> Signup and view all the answers

What are some clinical features of infective endocarditis?

<p>Clinical features include persistent fever, night sweats, weight loss, and new signs of valve dysfunction, along with embolic phenomena like strokes.</p> Signup and view all the answers

Explain how Staphylococcus epidermidis is related to infective endocarditis.

<p>Staphylococcus epidermidis is associated with postoperative endocarditis following cardiac surgery and is considered a coagulase-negative staphylococcus.</p> Signup and view all the answers

What is the typical course of action for managing life-long antibiotic therapy in patients with infective endocarditis?

<p>Patients with infective endocarditis may require life-long antibiotic therapy, especially in cases such as Q fever endocarditis caused by Coxiella burnetii.</p> Signup and view all the answers

What is the significance of 'HACEK' bacteria in infective endocarditis?

<p>HACEK bacteria refer to a group of fastidious Gram-negative organisms that account for 3-4% of infective endocarditis cases.</p> Signup and view all the answers

Describe the relationship between Brucella endocarditis and animal contact.

<p>Brucella endocarditis is associated with a history of contact with goats or cattle, often affecting the aortic valve.</p> Signup and view all the answers

What are the late signs of infective endocarditis?

<p>Digital clubbing is considered a late sign of infective endocarditis, indicating chronic infection.</p> Signup and view all the answers

Study Notes

Infective Endocarditis

  • Caused by microbial infection of heart valves, chambers, blood vessels, or congenital anomalies.
  • Native and prosthetic valves can be affected.
  • Incidence: 5-15 cases per 100,000 annually.
  • Pre-existing conditions linked to infective endocarditis: Rheumatic heart disease (24%), Congenital heart disease (19%), Cardiac abnormalities (25%), No pre-existing cardiac abnormalities (32%).

Pathophysiology

  • Often occurs at sites of existing endocardial damage.
  • Particularly virulent organisms (e.g., Staphylococcus aureus) can cause it in previously healthy hearts.

Microbiology

  • Most cases (over 75%) caused by streptococci or staphylococci.
  • Viridans streptococci (e.g., Streptococcus mitis, Strep sanguis) common in subacute endocarditis. Enter into bloodstream through oral activities (chewing, brushing, dental procedures).
  • Staphylococcus aureus now the most frequent cause of acute endocarditis.
  • Post-operative infections often involve coagulase-negative staphylococci (e.g., Staph. epidermidis).
  • Q fever endocarditis (caused by Coxiella burnetii) linked to farm animal contact.
  • Aortic valve commonly affected. Other symptoms possible: hepatitis, pneumonia, and purpura (skin discoloration)

Clinical Features

Subacute Endocarditis

  • Suspected in patients with congenital/valvular heart disease presenting with persistent fever, unusual fatigue, night sweats, weight loss, or new heart valve/heart failure issues.
  • Embolic stroke or peripheral arterial embolism possible, less frequently.
  • Symptoms include purpura, petechial hemorrhages, splinter hemorrhages, Osler's nodes.
  • Digital clubbing (late sign).
  • Spleen frequently affected.

Acute Endocarditis

  • Severe febrile illness, prominent heart murmurs that change over time, and petechiae (small red spots on skin).
  • Clinical stigmata of chronic endocarditis typically absent.
  • Embolic events common.
  • Rapid development of cardiac or renal failure possible.
  • Abscesses may be detected by echocardiography.
  • Partially treated acute endocarditis can resemble subacute endocarditis.

Post-operative Endocarditis

  • Unexplained fever in patients after heart valve surgery.
  • Infection usually involves the valve ring.
  • High morbidity & mortality.

Investigations

  • Blood cultures.
  • Echocardiography.
  • Elevated erythrocyte sedimentation rate (ESR), normocytic normochromic anemia.
  • EKG may show AV block (from aortic root abscess) or embolus-related infarcts.
  • Chest X-ray might reveal heart failure and cardiomegaly.

Management

  • Multidisciplinary approach (physician, surgeon, microbiologist).
  • Empirical treatment depends on presentation, suspected organism, and prosthetic valve/penicillin allergy.
  • Subacute presentation: Amoxicillin (2g IV 6x daily), possibly with gentamicin.
  • Acute presentation: Vancomycin (1g IV twice daily), gentamicin (1 mg/kg IV twice daily), dose adjusted per antibiotic levels.
  • Suspected prosthetic valve endocarditis: Vancomycin, gentamicin, and rifampicin (300-600 mg orally twice daily).
  • Following identification of the organism, determine minimum inhibitory concentration (MIC).

Indications for Cardiac Surgery

  • Heart failure from valve damage.
  • Treatment failure (uncontrolled/persistent infection).
  • Large vegetations on left-sided valves with a high embolus risk.
  • Abscess formation.

Prevention

  • Routine antibiotic prophylaxis for interventional procedures is no longer standard.
  • May be considered for highest-risk individuals.
  • High-risk cardiac conditions requiring prophylaxis:
    • Prosthetic cardiac valves.
    • History of infective endocarditis.
    • Congenital heart disease (Unrepaired cyanotic CHD, surgery/catheter intervention in first 6 months post-procedure, repaired CHD with residual defect).
    • Cardiac transplant recipients with valvular disease.

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Description

This quiz explores the causes, incidence, and microbiology of infective endocarditis. Learn about the pathogens involved, pre-existing conditions, and how infections occur in healthy and damaged hearts. Test your knowledge on this critical cardiac condition.

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