Chapter 1 |Mixing
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Questions and Answers

Why is mixing considered a fundamental step in most process sequences?

  • To create an ordered system of particles
  • To decrease heat transfer
  • To decrease the overall composition of the mixture
  • To randomize dissimilar particles within a system (correct)

Which term is synonymous with mixing according to the text?

  • Dissolution
  • Diffusion
  • Segregation
  • Blending (correct)

What is the main purpose of mixing in the context of pharmaceutical products?

  • To secure uniformity of composition (correct)
  • To increase segregation
  • To reduce physical and chemical reactions
  • To separate the components

In the mixing process, what happens to dissimilar particles within a system?

<p>They are randomized (C)</p> Signup and view all the answers

Which of the following is NOT a reason for carrying out mixing in pharmaceutical manufacturing?

<p>To promote segregation (D)</p> Signup and view all the answers

What additional process does agitation during mixing supplement in the context of chemical reactions?

<p>Diffusion (A)</p> Signup and view all the answers

What are the two primary components of a liquid mixing system?

<p>Tank and means of supplying energy (C)</p> Signup and view all the answers

Which component is used to direct the bulk movement of material in mixers?

<p>Ducts (C)</p> Signup and view all the answers

Which type of mixing is usually more feasible for limited volumes of materials?

<p>Batch mixing (A)</p> Signup and view all the answers

How are impellers classified in terms of mixing liquids?

<p>By the type of flow pattern they produce (D)</p> Signup and view all the answers

Which flow pattern is perpendicular to the impeller shaft?

<p>Radial flow (C)</p> Signup and view all the answers

What serves to direct the flow of material within the vessel besides supplying power?

<p>Impellers (C)</p> Signup and view all the answers

What kind of mixing occurs when shear reduces the scale of segregation by thinning dissimilar layers?

<p>Diffusive mixing (C)</p> Signup and view all the answers

How does diffusive mixing by diffusion reduce the intensity of segregation?

<p>By exchanging positions of particles within the powder bed (C)</p> Signup and view all the answers

What equipment is used for rapid overall mixing involving tumbling motion?

<p>Batch Tumblers/Blenders (B)</p> Signup and view all the answers

Which geometric form is NOT mentioned as a type of tumbler blender commercially available?

<p>Pyramid (A)</p> Signup and view all the answers

In a tumbling mixer, what enhances the resulting tumbling motion?

<p>Lifter blades or baffles (C)</p> Signup and view all the answers

What is the main effect of shear occurring between regions of different composition and parallel to their interface?

<p>Reduces scale of segregation (B)</p> Signup and view all the answers

Which type of blender is recommended for precision blending?

<p>Twin-shell blenders (D)</p> Signup and view all the answers

What type of motion is not conductive to efficient mixing in cubical and polyhedron-shaped blenders?

<p>Sliding action (D)</p> Signup and view all the answers

What is a drawback associated with ribbon mixers?

<p>Difficult to clean (D)</p> Signup and view all the answers

What type of motion characterizes the mixing pattern in double cone blenders?

<p>Rolling motion (D)</p> Signup and view all the answers

Which mixer exhibits shearing action between moving blades and trough?

<p>Agitator mixer (C)</p> Signup and view all the answers

What property of powders makes them difficult to mix due to agglomeration?

<p>High forces of cohesion (D)</p> Signup and view all the answers

What is considered as a practical upper limit for the viscosity of materials that can be mixed using turbines or flat blade devices?

<p>10 poise (A)</p> Signup and view all the answers

Which of the following statements is true about mixing thick creams, ointments, and pastes?

<p>They have a high viscosity, making it difficult to generate turbulence within their bulk. (A)</p> Signup and view all the answers

What is a characteristic of turbines or flat blade mixing devices?

<p>They are insensitive to changes in power consumption, density, and viscosity. (D)</p> Signup and view all the answers

In the mixing of two immiscible liquids, what is the primary mechanism involved?

<p>Subdivision of one phase into globules and distributing them throughout the bulk fluid. (C)</p> Signup and view all the answers

What are the two primary forces involved in the mixing of two immiscible liquids?

<p>Interfacial tension and shear forces (C)</p> Signup and view all the answers

How is the selection of mixing equipment determined for low-viscosity systems?

<p>Based on the mechanism by which intense shearing forces can be generated (C)</p> Signup and view all the answers

What type of mixing involves systems where spontaneous, irreversible, and complete mixing would take place by diffusion?

<p>Positive mixing (B)</p> Signup and view all the answers

Which type of mixing is more difficult to form and maintain, requiring a higher degree of mixing?

<p>Negative mixing (C)</p> Signup and view all the answers

What occurs in neutral mixing systems unless acted upon by an external energy input?

<p>Remain static (D)</p> Signup and view all the answers

Forces of shear during fluid mixing are generated by interactions between moving fluids and:

<p>Solid surfaces (B)</p> Signup and view all the answers

What is the derivative of velocity with respect to distance measured normal to the direction of flow known as?

<p>Shear rate (A)</p> Signup and view all the answers

What classification depends on the relationship between shear rates and applied stress for fluids?

<p>Rheological classification (C)</p> Signup and view all the answers

What type of mixer is characterized by the development of a vortex at the center of the vessel?

<p>Impeller mixer (D)</p> Signup and view all the answers

Which fluid mixing device induces tangential flow but does not produce mixing except near the tank walls?

<p>Grid mixer (A)</p> Signup and view all the answers

What is the drawback associated with the formation of a vortex during mixing?

<p>Increased likelihood of foaming (B)</p> Signup and view all the answers

Which device typically includes vanes, baffles, screws, grids, or combinations for efficient mixing?

<p>Impeller mixer (C)</p> Signup and view all the answers

At what viscosity range is the formation of a vortex during mixing considered undesirable?

<p>&lt; 20,000 cps (B)</p> Signup and view all the answers

Which type of flow pattern is characteristic of turbines with blades arranged perpendicular to the impeller shaft?

<p>Radial flow (C)</p> Signup and view all the answers

What is the primary effect of a propeller in mixing liquids?

<p>Producing axial flow (B)</p> Signup and view all the answers

How are turbines distinguished from propellers in terms of blade pitch?

<p>Turbines have blades with varying pitch (B)</p> Signup and view all the answers

Which impeller type induces radial flow by centrifugal action?

<p>Turbines with 90-degree blades (C)</p> Signup and view all the answers

What is a key characteristic of turbines' design that allows operation in highly viscous fluids?

<p>Simple and rugged design (C)</p> Signup and view all the answers

In what type of fluid are propellers most efficient?

<p>Low-viscosity liquids (D)</p> Signup and view all the answers

What type of flow pattern is induced primarily by the setup of propellers?

<p>Axial flow (D)</p> Signup and view all the answers

What type of motion characterizes the mixing pattern in double cone blenders?

<p>Rolling (C)</p> Signup and view all the answers

Which blender type is NOT recommended for precision blending according to the text?

<p>Planetary mixer (B)</p> Signup and view all the answers

What is the drawback associated with ribbon mixers mentioned in the text?

<p>Higher power requirement (C)</p> Signup and view all the answers

Which type of mixing is NOT conducive to efficient mixing in cubical and polyhedron-shaped blenders?

<p>Sliding (A)</p> Signup and view all the answers

What additional mixing action occurs in twin-shell blenders during each revolution?

<p>Agglomeration (B)</p> Signup and view all the answers

What is a common drawback associated with sigma blade and planetary mixers mentioned in the text?

<p>Relatively higher power requirement (B)</p> Signup and view all the answers

What is the practical upper limit of viscosity for the application of turbines or flat blade mixing devices?

<p>15 poise (C)</p> Signup and view all the answers

What type of forces play a role in the mixing of two immiscible liquids?

<p>Surface tension and shear forces (C)</p> Signup and view all the answers

How are high shear rates achieved in low-viscosity systems during mixing?

<p>By passing the fluid under high pressure through small orifices (C)</p> Signup and view all the answers

What is the primary function of a turbine or flat blade design in mixing thick creams and ointments?

<p>Generate turbulence within the bulk (B)</p> Signup and view all the answers

In a polyphase system, what is the effect of the first force on the globules within the fluid?

<p>Maintains globule shape integrity (D)</p> Signup and view all the answers

Which factor influences the selection of equipment for generating intense shearing forces in liquid mixtures?

<p>Viscosity of the liquids (D)</p> Signup and view all the answers

Flashcards

Mixing (in processes)

Randomizing dissimilar particles in a system.

Blending

Another word for mixing.

Mixing (pharmaceuticals)

Ensuring uniform composition in pharmaceutical products.

Randomization (in mixing)

Dissimilar particles are mixed in a random arrangement.

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Mixing (preventing segregation)

Preventing separation of different components in a mixture.

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Mixing & Agitation (chemical reactions)

Mixing enhances diffusion, which aids chemical reactions.

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Liquid Mixing System (components)

A tank plus a method to add energy to mix.

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Mixers (material movement)

Ducts direct the movement of materials in a mixer.

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Batch Mixing

Mixing a limited amount of material at once.

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Impeller Classification

Impellers are categorized by the flow pattern they create.

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Radial Flow

Mixing flow perpendicular to the impeller shaft.

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Impellers (flow direction)

Impellers direct the material flow in the mixer vessel, along with providing energy for mixing.

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Diffusive Mixing

Mixing done by reducing segregation by thinning dissimilar layers.

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Diffusive mixing (segregation reduction)

Exchanging positions of particles within the powder bed.

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Batch Tumblers/Blenders

Equipment for rapid, overall mixing with tumbling motion.

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Tumbler Blender Shapes

Common tumbler blenders are cylindrical.

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Tumbling Mixer Enhancement

Lifter blades or baffles enhance tumbling motion in tumbling mixers.

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Shear (segregation reduction)

Shear reduces segregation by changing composition regions.

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Precision Blending Mixer

Twin-shell blenders are preferred for precise blending.

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Unfavorable Mixing Motion

Sliding motion is poor in cubical/polyhedron blenders.

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Ribbon Mixer Drawback

Ribbon mixers are harder to clean than other types.

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Double Cone Blender Mixing

Characterized by rolling motion.

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Agitator Mixer Action

Shearing happens between moving blades and the trough.

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Powder Mixing Challenges

Powders' high cohesion causes difficulty mixing due to agglomeration.

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Viscosity Limit (turbine/flat blade)

Typically 10 poise is the upper limit for fluids mixed by turbines or blades.

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