Blood-Brain Barrier and Brain Tumor Drug Delivery

What is primarily responsible for controlling the entry of blood circulating agents into the brain?

Which cellular microenvironment plays a crucial role in brain drug delivery and targeting?

What type of transport machineries are used by BCECs to control the transportation process into the brain?

What is the main function of the restrictive tight junctional complexes formed by BCECs?

What makes brain drug delivery and targeting very challenging?

What is the main purpose of designing intelligent molecular therapies mentioned in the text?

According to the passage, what contributes mainly to the protection of brain from undesired blood circulating agents?

Based on the text, what makes BBB impermeable to many compounds?

What is a central step for engineering of intelligent seamless therapeutics, as mentioned in the passage?

What do BCECs show different features in comparison with peripheral endothelial cells?

Blood brain barrier (BBB) allows free passage of biomolecules and compounds into the brain

Brain capillary endothelial cells (BCECs) form unique biological structure and architecture in association with astrocytes and pericytes

BCECs express non-restrictive tight junctional complexes that allow free paracellular inward/outward traverse of biomolecules/compounds

The transportation process through carrier and/or receptor mediated transport machineries is not controlled by BCECs

BBB restrictiveness makes brain drug delivery and targeting easy

Intelligent molecular therapies should be designed using transport machineries for the efficient delivery of designated drugs into the brain.

The main purpose of smart pharmaceuticals is to provide simultaneous imaging and therapy (multimodal theranostics).

The exceptional functional presence of BBB is responsible for controlling inward and outward transportation mechanisms.

The permeability of BBB appears to be regulated by a range of intricate transport machineries located at the membrane of the BCECs.

The tight junctional characteristics of BCECs make BBB permeable to many compounds.