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Questions and Answers
What is primarily responsible for controlling the entry of blood circulating agents into the brain?
What is primarily responsible for controlling the entry of blood circulating agents into the brain?
- Pericytes
- Astrocytes
- Tight junctional complexes (correct)
- Brain capillary endothelial cells
Which cellular microenvironment plays a crucial role in brain drug delivery and targeting?
Which cellular microenvironment plays a crucial role in brain drug delivery and targeting?
- Perelman School of Medicine
- Astrocytes and pericytes only
- Brain capillary endothelial cells only
- BCECs, astrocytes, and pericytes (correct)
What type of transport machineries are used by BCECs to control the transportation process into the brain?
What type of transport machineries are used by BCECs to control the transportation process into the brain?
- Passive diffusion only
- Active transport only
- Facilitated diffusion
- Carrier and/or receptor mediated (correct)
What is the main function of the restrictive tight junctional complexes formed by BCECs?
What is the main function of the restrictive tight junctional complexes formed by BCECs?
What makes brain drug delivery and targeting very challenging?
What makes brain drug delivery and targeting very challenging?
What is the main purpose of designing intelligent molecular therapies mentioned in the text?
What is the main purpose of designing intelligent molecular therapies mentioned in the text?
According to the passage, what contributes mainly to the protection of brain from undesired blood circulating agents?
According to the passage, what contributes mainly to the protection of brain from undesired blood circulating agents?
Based on the text, what makes BBB impermeable to many compounds?
Based on the text, what makes BBB impermeable to many compounds?
What is a central step for engineering of intelligent seamless therapeutics, as mentioned in the passage?
What is a central step for engineering of intelligent seamless therapeutics, as mentioned in the passage?
What do BCECs show different features in comparison with peripheral endothelial cells?
What do BCECs show different features in comparison with peripheral endothelial cells?
Blood brain barrier (BBB) allows free passage of biomolecules and compounds into the brain
Blood brain barrier (BBB) allows free passage of biomolecules and compounds into the brain
Brain capillary endothelial cells (BCECs) form unique biological structure and architecture in association with astrocytes and pericytes
Brain capillary endothelial cells (BCECs) form unique biological structure and architecture in association with astrocytes and pericytes
BCECs express non-restrictive tight junctional complexes that allow free paracellular inward/outward traverse of biomolecules/compounds
BCECs express non-restrictive tight junctional complexes that allow free paracellular inward/outward traverse of biomolecules/compounds
The transportation process through carrier and/or receptor mediated transport machineries is not controlled by BCECs
The transportation process through carrier and/or receptor mediated transport machineries is not controlled by BCECs
BBB restrictiveness makes brain drug delivery and targeting easy
BBB restrictiveness makes brain drug delivery and targeting easy
Intelligent molecular therapies should be designed using transport machineries for the efficient delivery of designated drugs into the brain.
Intelligent molecular therapies should be designed using transport machineries for the efficient delivery of designated drugs into the brain.
The main purpose of smart pharmaceuticals is to provide simultaneous imaging and therapy (multimodal theranostics).
The main purpose of smart pharmaceuticals is to provide simultaneous imaging and therapy (multimodal theranostics).
The exceptional functional presence of BBB is responsible for controlling inward and outward transportation mechanisms.
The exceptional functional presence of BBB is responsible for controlling inward and outward transportation mechanisms.
The permeability of BBB appears to be regulated by a range of intricate transport machineries located at the membrane of the BCECs.
The permeability of BBB appears to be regulated by a range of intricate transport machineries located at the membrane of the BCECs.
The tight junctional characteristics of BCECs make BBB permeable to many compounds.
The tight junctional characteristics of BCECs make BBB permeable to many compounds.
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