Blood-Brain Barrier and Drug Delivery

Blood-Brain Barrier (BBB) mainly relies on the astrocytic end feet and pericytes for its protective function.

The permeability of BBB is regulated by transport machineries located at the membrane of the brain capillary endothelial cells (BCECs).

The article suggests that understanding the biofunctions of BBB is not crucial for engineering intelligent seamless therapeutics.

BBB is permeable to many compounds due to the tight junctional characteristics of brain capillary endothelial cells (BCECs).

The exceptional functional presence of BBB does not play a role in the need for advanced smart multifunctional nanomedicines for effective brain drug delivery and targeting.

Blood-Brain Barrier (BBB) allows free movement of biomolecules and compounds across brain capillary endothelial cells (BCECs)

The BBB restricts the entry of blood circulating agents into the brain

BCECs express tight junctional complexes that prevent the paracellular traversal of biomolecules/compounds

The transportation process through the BBB is solely passive and does not involve carrier or receptor mediated transport machineries

Brain drug delivery and targeting is not challenging due to the restrictive nature of the BBB

What are the specific transport machineries at the blood brain barrier (BBB) that control the entry of blood circulating agents into the brain?

What is the role of brain capillary endothelial cells (BCECs) in the blood brain barrier (BBB)?

Why is brain drug delivery and targeting considered very challenging?

What is the main function of the tight junctional complexes expressed by brain capillary endothelial cells (BCECs)?

How do brain capillary endothelial cells (BCECs) selectively control the transportation process at the blood brain barrier (BBB)?

What is the main function of the blood-brain barrier (BBB)?

What are the essential components that make the BBB impermeable to many compounds?

Why is fully understanding the biofunctions of BBB considered a central step for engineering intelligent seamless therapeutics?

What role do the brain capillary endothelial cells (BCECs) play in the permeability of the BBB?

Why are advanced smart multifunctional nanomedicines needed for effective brain drug delivery and targeting?