20 Questions
Blood-Brain Barrier (BBB) mainly relies on the astrocytic end feet and pericytes for its protective function.
False
The permeability of BBB is regulated by transport machineries located at the membrane of the brain capillary endothelial cells (BCECs).
True
The article suggests that understanding the biofunctions of BBB is not crucial for engineering intelligent seamless therapeutics.
False
BBB is permeable to many compounds due to the tight junctional characteristics of brain capillary endothelial cells (BCECs).
False
The exceptional functional presence of BBB does not play a role in the need for advanced smart multifunctional nanomedicines for effective brain drug delivery and targeting.
False
Blood-Brain Barrier (BBB) allows free movement of biomolecules and compounds across brain capillary endothelial cells (BCECs)
False
The BBB restricts the entry of blood circulating agents into the brain
True
BCECs express tight junctional complexes that prevent the paracellular traversal of biomolecules/compounds
True
The transportation process through the BBB is solely passive and does not involve carrier or receptor mediated transport machineries
False
Brain drug delivery and targeting is not challenging due to the restrictive nature of the BBB
False
What are the specific transport machineries at the blood brain barrier (BBB) that control the entry of blood circulating agents into the brain?
carrier and/or receptor mediated transport machineries
What is the role of brain capillary endothelial cells (BCECs) in the blood brain barrier (BBB)?
BCECs express restrictive tight junctional complexes that block the paracellular inward/outward traverse of biomolecules/compounds and selectively/specifically control the transportation process through carrier and/or receptor mediated transport machineries.
Why is brain drug delivery and targeting considered very challenging?
The excellent barrier restrictiveness of the BBB makes brain drug delivery and targeting very challenging.
What is the main function of the tight junctional complexes expressed by brain capillary endothelial cells (BCECs)?
They prevent the paracellular inward/outward traverse of biomolecules/compounds.
How do brain capillary endothelial cells (BCECs) selectively control the transportation process at the blood brain barrier (BBB)?
Through carrier and/or receptor mediated transport machineries.
What is the main function of the blood-brain barrier (BBB)?
The main function of the blood-brain barrier (BBB) is to protect the brain from undesired blood circulating agents.
What are the essential components that make the BBB impermeable to many compounds?
The tight junctional characteristics of brain capillary endothelial cells (BCECs) make the BBB impermeable to many compounds.
Why is fully understanding the biofunctions of BBB considered a central step for engineering intelligent seamless therapeutics?
Fully understanding the biofunctions of BBB is considered a central step for engineering intelligent seamless therapeutics because it involves the design of therapeutics consisting of homing devices for targeting, imaging moieties for detecting, and stimuli-responsive devices for on-demand liberation of therapeutic agents.
What role do the brain capillary endothelial cells (BCECs) play in the permeability of the BBB?
The permeability of BBB is regulated by a range of intricate transport machineries located at the membrane of the BCECs.
Why are advanced smart multifunctional nanomedicines needed for effective brain drug delivery and targeting?
Advanced smart multifunctional nanomedicines are needed for effective brain drug delivery and targeting due to the exceptional functional presence of BBB, which selectively controls inward and outward transportation mechanisms.
Explore the impacts of the blood-brain barrier on drug delivery and targeting of brain tumors in this review article. Gain insights into the challenges and opportunities for delivering therapeutic agents to the brain.
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