Immunosuppressive Therapy Lecture Quiz

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Which of the following is a common application of immunosuppressive therapy?

Treatment of psoriasis (correct)
Treatment of diabetes
Treatment of asthma
Treatment of hypertension

What is the principal approach to immunosuppressive therapy today?

Employing monotherapy with severe toxicities
Increasing the risk of infection and malignancies
Using nonselective drugs
Altering lymphocyte function using drugs or antibodies against immune proteins (correct)

Why are combination regimens of immunosuppressive agents generally employed?

To cause disease
To disrupt various levels of T-cell activation
To prevent severe toxicities when used as monotherapy (correct)
To increase the risk of infection and malignancies

How do earlier nonselective drugs affect the immune system?

Suppress both the antibody-mediated (humoral) and cell-mediated arms of the immune system (B) Signup and view all the answers

What is the potential drawback of immunosuppressive agents?

Increased risk of infection and malignancies (D) Signup and view all the answers

Match the immunosuppressive therapy application with the corresponding medical condition:

Organ transplantation = Immunosuppressive therapy application Psoriasis = Immunosuppressive therapy application Rheumatoid arthritis = Immunosuppressive therapy application Multiple sclerosis = Immunosuppressive therapy application Signup and view all the answers

Match the immunosuppressive drug regimen with its characteristic:

Consists of two to four agents with different mechanisms of action = Immunosuppressive drug regimen characteristic Alters lymphocyte function using drugs or antibodies against immune proteins = Immunosuppressive drug regimen characteristic Employed at lower doses due to severe toxicities when used as monotherapy = Immunosuppressive drug regimen characteristic Disrupts various levels of T-cell activation = Immunosuppressive drug regimen characteristic Signup and view all the answers

Match the immunosuppressive therapy drawback with its effect:

Potential to cause disease = Immunosuppressive therapy drawback Increases the risk of infection = Immunosuppressive therapy drawback Increases the risk of malignancies = Immunosuppressive therapy drawback Potential to suppress both antibody-mediated and cell-mediated immune system arms = Immunosuppressive therapy drawback Signup and view all the answers

Match the historical nonselective immunosuppressive drugs effect with its impact:

Frequent suffering from infections due to suppression of immune system arms = Historical nonselective immunosuppressive drugs effect Suppression of both antibody-mediated and cell-mediated arms of the immune system = Historical nonselective immunosuppressive drugs effect Severe toxicities when used as monotherapy = Historical nonselective immunosuppressive drugs effect Nonselective suppression leading to severe toxicities = Historical nonselective immunosuppressive drugs effect Signup and view all the answers

Match the current approach to immunosuppressive therapy with its strategy:

Alter lymphocyte function using drugs or antibodies against immune proteins = Current approach to immunosuppressive therapy strategy Employ a combination of immunosuppressive agents with different mechanisms of action at lower doses = Current approach to immunosuppressive therapy strategy Disrupt various levels of T-cell activation using different agents = Current approach to immunosuppressive therapy strategy Minimize occurrence or impact of deleterious effects of exaggerated or inappropriate immune responses = Current approach to immunosuppressive therapy strategy Signup and view all the answers

Match the immunosuppressive therapy with its corresponding medical condition:

Organ transplantation = Immunosuppressive therapy Psoriasis = Immunosuppressive therapy Rheumatoid arthritis = Immunosuppressive therapy Multiple sclerosis = Immunosuppressive therapy Signup and view all the answers

Match the immunosuppressive agent's potential drawback with its effect:

Increased risk of infection = Immunosuppressive agents Increased risk of malignancies = Immunosuppressive agents Potential to cause disease = Immunosuppressive agents Minimization of inappropriate immune responses = Immunosuppressive agents Signup and view all the answers

Match the immunosuppressive drug regimen with its characteristic:

Two to four agents with different mechanisms of action = Immunosuppressive drug regimens Nonselective earlier drugs causing infection due to suppression of both immune system arms = Immunosuppressive drug regimens Alteration of lymphocyte function using drugs or antibodies against immune proteins = Immunosuppressive drug regimens Severe toxicities when used as monotherapy, thus generally employed in combination regimens at lower doses = Immunosuppressive drug regimens Signup and view all the answers

Match the historical nonselective immunosuppressive drugs effect with its impact:

Frequent infection due to suppression of both humoral and cell-mediated arms of the immune system = Nonselective immunosuppressive drugs effect Severe toxicities when used as monotherapy, leading to combination regimens at lower doses = Nonselective immunosuppressive drugs effect Alteration of lymphocyte function using drugs or antibodies against immune proteins = Nonselective immunosuppressive drugs effect Minimization of inappropriate immune responses = Nonselective immunosuppressive drugs effect Signup and view all the answers

Match the current approach to immunosuppressive therapy with its strategy:

Alteration of lymphocyte function using drugs or antibodies against immune proteins = Current approach to immunosuppressive therapy Combination of two to four agents with different mechanisms of action disrupting various levels of T-cell activation = Current approach to immunosuppressive therapy Minimization of inappropriate immune responses while avoiding severe toxicities through combination regimens at lower doses = Current approach to immunosuppressive therapy Frequent occurrence or impact minimization of deleterious effects of exaggerated or inappropriate immune responses = Current approach to immunosuppressive therapy Signup and view all the answers