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Questions and Answers
What is the purpose of therapeutic drug monitoring (TDM) of immunosuppressant blood levels?
What is the purpose of therapeutic drug monitoring (TDM) of immunosuppressant blood levels?
- To limit the risk of over or underexposure to the drugs (correct)
- To promote acute rejection of solid organ transplantation
- To decrease the variability in pharmacological response
- To increase the risk of overexposure to the drugs
What is a potential consequence of underexposure to immunosuppressive drugs?
What is a potential consequence of underexposure to immunosuppressive drugs?
- Decreased variability in pharmacological response
- Lack of efficacy in preventing acute rejection (correct)
- Improved therapeutic monitoring
- Decreased risk of toxicity
Why is variability in pharmacological response a concern with immunosuppressive drugs?
Why is variability in pharmacological response a concern with immunosuppressive drugs?
- It only causes overexposure and toxicity
- It reduces the need for therapeutic drug monitoring
- It has no impact on the effectiveness of the drugs
- It may cause underexposure leading to lack of efficacy (correct)
What is a relevant line of investigation in pharmacology related to immunosuppressive drugs?
What is a relevant line of investigation in pharmacology related to immunosuppressive drugs?
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Despite extensive use of TDM, why does the incidence of acute rejection remain high?
Despite extensive use of TDM, why does the incidence of acute rejection remain high?
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