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Dose Optimization of Immunosuppressive Drugs (PHCL 439)

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Dose Optimization of Immunosuppressive Drugs (PHCL 439)

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Questions and Answers

Which drug is mentioned as an immunosuppressant in the text?

Cyclosporine (correct)

Ibuprofen

Metformin

Amoxicillin

What is the main cause of variability in pharmacological response to immunosuppressive drugs?

Variation in drug color

Variation in pharmacodynamics

Variation in drug brand

Variation in pharmacokinetics (correct)

What is the potential consequence of underexposure to immunosuppressive drugs?

Reduced toxicity

Increased efficacy

No effect on the patient

Lack of efficacy (correct)

Which term refers to the process of measuring drug levels to ensure appropriate dosing?

Therapeutic Drug Monitoring (TDM) Signup and view all the answers

What is the purpose of dose optimization of immunosuppressive drugs?

To achieve optimal drug levels for efficacy and safety Signup and view all the answers

What is the mechanism of action of cyclosporine, tacrolimus, and sirolimus?

Inhibition of calcineurin Signup and view all the answers

What is the significance of variability in pharmacokinetics of immunosuppressive drugs?

It can lead to underexposure or over-exposure, affecting drug efficacy and causing toxicity Signup and view all the answers

What is the purpose of therapeutic drug monitoring (TDM) for immunosuppressive drugs?

To individualize drug dosage based on drug levels in the blood Signup and view all the answers

What is the role of immunosuppressive drugs in solid organ transplantation?

Prevention of acute rejection Signup and view all the answers

What is the main concern regarding variability in pharmacological response to immunosuppressive drugs?

Underexposure leading to lack of efficacy or over-exposure causing toxicity Signup and view all the answers