Immunology Workbook
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Questions and Answers

Which immunoglobulin is most commonly found in blood and tissue fluid?

  • IgM
  • IgE
  • IgD
  • IgG (correct)
  • Which immunoglobulin is primarily associated with allergic reactions?

  • IgM
  • IgA
  • IgD
  • IgE (correct)
  • What is the primary role of IgD antibodies on B lymphocyte membranes?

  • Serving as antigen-specific receptors (correct)
  • Defending against pathogens
  • Activating the complement system
  • Transporting immune cells
  • Which immunoglobulin serves as the earliest antibody response in a primary immune response?

    <p>IgM (C)</p> Signup and view all the answers

    How is maternal IgG provided to newborns?

    <p>Crossing the placenta (A)</p> Signup and view all the answers

    What is the relationship between phagocytes and pathogens?

    <p>Phagocytes engulf and destroy pathogens (A)</p> Signup and view all the answers

    Which statement about IgE is true?

    <p>IgE is typically found in high levels in asthmatics. (A)</p> Signup and view all the answers

    What are the toxic materials found in the phagolysosome that kill pathogens?

    <p>Antimicrobial agents and enzymes (D)</p> Signup and view all the answers

    What is defined as microscopic organisms that may be beneficial or pathogenic?

    <p>Microbes (B)</p> Signup and view all the answers

    Which substance is specifically capable of eliciting an immune response?

    <p>Antigen (C)</p> Signup and view all the answers

    What role do antibodies primarily play in the immune system?

    <p>Killing or weakening pathogens (A)</p> Signup and view all the answers

    Which type of cytokine is produced by Th1 T-helper cells?

    <p>Type-1 cytokines (D)</p> Signup and view all the answers

    Which immunoglobulin is found in the respiratory tract and digestive system?

    <p>IgA (D)</p> Signup and view all the answers

    Cytokines produced by Th2 T-helper cells are classified as what type?

    <p>Type-2 cytokines (D)</p> Signup and view all the answers

    What can antibodies activate in the presence of lysosome?

    <p>Complement system (B)</p> Signup and view all the answers

    Which of the following is NOT a type of cytokine?

    <p>Microbes (B)</p> Signup and view all the answers

    What is the primary role of antigen-presenting cells in the immune system?

    <p>They activate immature T cells. (C)</p> Signup and view all the answers

    Where are antigen-presenting cells primarily found in the body?

    <p>In nodes and spleen. (A)</p> Signup and view all the answers

    Which of the following best describes the process of stimulating B cells by antigen-presenting cells?

    <p>It promotes B cell growth and differentiation. (D)</p> Signup and view all the answers

    What function do the messengers mentioned in the context of adaptive immunity serve?

    <p>They regulate the immune response. (D)</p> Signup and view all the answers

    What triggers the adaptive immune response according to the information provided?

    <p>Cell surface receptors on antigen-presenting cells. (D)</p> Signup and view all the answers

    Which statement correctly describes the role of immunology?

    <p>Immunology is the study of the body's defense systems and responses. (B)</p> Signup and view all the answers

    What is a key characteristic of non-specific (innate) immunity?

    <p>It is the body's first line of defense against infections. (D)</p> Signup and view all the answers

    Which of the following components is part of the adaptive (acquired) immune system?

    <p>Helper T cells (C)</p> Signup and view all the answers

    Which of the following correctly differentiates between non-specific and adaptive immunity?

    <p>Non-specific immunity acts broadly while adaptive immunity targets specific pathogens. (D)</p> Signup and view all the answers

    Which is not considered a cell of the non-specific immune system?

    <p>B cells (A)</p> Signup and view all the answers

    What method is recommended for note-taking during the immunology sessions?

    <p>Creating memory maps or spider diagrams. (C)</p> Signup and view all the answers

    Which of the following is an outcome for students after the immunology session?

    <p>Ability to identify organs of the immune system. (B)</p> Signup and view all the answers

    What is the intended duration to read the article on antibody-mediated vs. cell-mediated immunity?

    <p>10 minutes (A)</p> Signup and view all the answers

    What type of proteins are involved in promoting phagocytosis of bacteria?

    <p>Opsonins (D)</p> Signup and view all the answers

    Which process involves cells ingesting or engulfing other cells or particles?

    <p>Phagocytosis (D)</p> Signup and view all the answers

    What is the role of antigen presenting cells?

    <p>To process protein antigens into peptides (B)</p> Signup and view all the answers

    What is apoptosis commonly referred to as?

    <p>Programmed cell death (D)</p> Signup and view all the answers

    What component of the immune system plays a significant role in host defense and inflammation?

    <p>Complement system (D)</p> Signup and view all the answers

    Which of the following pathways is NOT part of the complement system activation?

    <p>Fibronectin pathway (A)</p> Signup and view all the answers

    What is the primary function of opsonins in the immune system?

    <p>To coat antigens for easier recognition (A)</p> Signup and view all the answers

    Which type of immune cell is involved in phagocytosis?

    <p>Neutrophils (B)</p> Signup and view all the answers

    What do mast cells secrete in response to hypersensitivity reactions?

    <p>Histamine (A), Antibodies (D)</p> Signup and view all the answers

    Where are mast cells derived from?

    <p>Bone marrow (A), Myeloid stem cells (D)</p> Signup and view all the answers

    What triggers the release of histamine by mast cells?

    <p>Antibodies (D)</p> Signup and view all the answers

    What is the primary function of dendritic cells in the immune system?

    <p>Linking innate and adaptive immunity (C)</p> Signup and view all the answers

    What type of immune response do mast cells contribute to?

    <p>Innate immune response (B)</p> Signup and view all the answers

    What type of cell are mast cells classified as?

    <p>Granulocyte (C)</p> Signup and view all the answers

    What is the characteristic content of the granules in mast cells?

    <p>Histamine and heparin (A)</p> Signup and view all the answers

    What differentiates mast cells from other immune cells?

    <p>Location of maturation (D)</p> Signup and view all the answers

    Flashcards

    IgD antibody function

    IgD is found in low levels in blood and cannot activate the complement system. It's a significant part of B lymphocyte receptors.

    IgE antibody function

    IgE is found in small amounts in serum and attached to mast cells/basophils. High levels are linked to allergies.

    IgG antibody function

    IgG is the most common antibody, found in blood/tissue fluid. It defends against toxins and microbes, is key in secondary immune responses, and acts as an opsonin.

    IgG function in newborns

    Maternal IgG is transferred across the placenta, providing passive immunity to newborns for several months.

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    IgM antibody function

    IgM is the largest immunoglobulin, often the first antibody response in a primary immune response, but is short-lived.

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    Phagocyte function

    Phagocytes engulf pathogens, forming a phagolysosome where toxins kill the pathogens.

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    Opsonin

    An opsonin is a substance that enhances phagocytosis.

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    Primary immune response

    The initial immune response to an antigen.

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    Immunology Definition

    The branch of biology that studies the immune system and its functions.

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    Natural Defense Systems

    The body's initial barriers against infection (e.g. skin, mucus, etc.).

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    Innate Immune System

    A non-specific immune response that provides immediate protection against pathogens.

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    Adaptive Immune System

    A specific immune response that develops after exposure to a pathogen.

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    Antibody-mediated Immunity

    An immune response that involves antibodies.

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    Cell-mediated Immunity

    An immune response that involves cells directly attacking pathogens.

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    Immune System Organs

    Physical structures that house and support the immune system.

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    Immunology Workbook

    A workbook to study Immunology concepts.

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    What are microbes?

    Microscopic organisms found in various environments like water, soil, and air. Some microbes are harmful (pathogenic), while others are beneficial to our health.

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    What is an antigen?

    Any substance that triggers an immune response in the body. It specifically reacts with antibodies or immune cells.

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    What are cytokines?

    Proteins that affect the immune system by either boosting or suppressing it. There are different types with specific roles.

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    Antibody

    Special proteins made by activated white blood cells (B cells) to fight infections. They can target and neutralize pathogens.

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    Immunoglobulin (Ig)

    Another name for antibodies. There are different classes of immunoglobulins, each with unique functions.

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    What is IgA?

    A type of antibody found in mucous membranes, saliva, tears, and breast milk. It protects against infections in these areas.

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    What is the function of secretory IgA?

    Found in mucosal linings, saliva, tears, and breast milk, it acts like a first line defense against pathogens.

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    What is the function of serum IgA?

    Found in the blood, it cannot activate the complement system to kill pathogens directly.

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    Antigen-Presenting Cells (APCs)

    Immune cells that display fragments of antigens on their surface to activate other immune cells, like T cells.

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    Adaptive Immunity

    The part of the immune system that learns to recognize and target specific pathogens. It adapts to new threats and builds long-lasting immunity.

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    Antigens

    Any substance that triggers an immune response. This can include proteins, carbohydrates, or even parts of bacteria or viruses.

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    What do APCs do?

    Antigen-presenting cells (APCs) play a crucial role in activating adaptive immunity by presenting antigen fragments to T cells.

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    What is the key function of the adaptive immune response?

    The adaptive immune response is a key regulator of the immune system. It's responsible for recognizing and attacking specific pathogens, building immunity, and providing long-term protection.

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    Phagocytosis

    The process where immune cells called phagocytes engulf and destroy foreign objects like bacteria, viruses, or cellular debris.

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    Apoptosis

    Programmed cell death, a natural process where cells are eliminated in a controlled manner, often due to damage or unnecessary growth.

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    Complement System

    A group of proteins in the blood that work together to defend against pathogens by directly destroying them or activating other immune cells.

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    What are the three pathways of the complement system?

    The three main pathways of the complement system are the classical pathway, the alternative pathway, and the lectin pathway. Each pathway is triggered by a different mechanism and ultimately leads to the activation of a cascade of proteins that ultimately destroys the pathogen.

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    Mast Cell Function

    Mast cells are innate immune cells that release histamine and other inflammatory mediators in response to allergens or pathogens. This attracts immune cells to the site of injury and helps defend against parasites.

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    What do mast cells release?

    Mast cells release a variety of inflammatory mediators, including histamine, heparin, and cytokines. Histamine dilates blood vessels, bringing more immune cells to the area.

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    Dendritic Cell Function

    Dendritic cells are antigen-presenting cells (APCs) that link the innate and adaptive immune systems. They capture and process antigens, then migrate to lymph nodes to present them to T cells, initiating an adaptive immune response.

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    What is hypersensitivity?

    Hypersensitivity is an exaggerated immune response to an antigen. It can range from mild allergic reactions to severe anaphylaxis.

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    How does histamine affect hypersensitivity?

    Histamine is a key mediator of hypersensitivity reactions. It dilates blood vessels and increases vascular permeability, causing symptoms like swelling, redness, and itching.

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    How do mast cells contribute to hypersensitivity?

    Mast cells release histamine and other inflammatory mediators in response to allergens or pathogens. These mediators contribute to the symptoms of hypersensitivity reactions, such as itching, swelling, and redness.

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    What is the role of mast cells in host defense?

    Mast cells play a vital role in host defense against parasitic infections. They release inflammatory mediators that attract immune cells and help fight the parasites.

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    Study Notes

    Immunology Workbook

    • This workbook is used alongside immunology sessions
    • Students complete tasks independently
    • Follow PowerPoint slides' instructions
    • Use various note-taking methods, spider diagrams, pictures, tables, to create comprehensive immunology notes
    • Preparation for the next session aims to consolidate knowledge
    • Learning outcomes for the session: define immunology, identify the terminology, describe the body's natural defenses, identify non-specific and adaptive immune systems' components/functions, distinguish between these, and locate immune system cells

    Introduction

    • Workbook's purpose: support immunology sessions.
    • First session focuses on introduction to immunology, self-directed learning.
    • Work through each slide, complete required activities.
    • Resources include documents and research articles for further knowledge.
    • Employ various note-taking methods (spider diagrams/pictures/tables) for effective information organization.
    • Complete notes are vital for next session learning consolidation.
    • Learning outcomes: define immunology, describe natural defenses, identify components/functions of non/adaptive immunity, differentiate between non/adaptive, locate immune system cells

    Antibody-Mediated vs. Cell-Mediated Immunity

    • Read article up to section 10 of 14
    • Duration: 15 minutes

    Immune System Organs/Tissues

    • Research and create own notes, spider diagram or memory map on immune system organs/tissues
    • Duration: 15 minutes
    • Reference provided resources for immune system organs information.

    Worksheet 1: Immunology Terminology

    • Notate and review new terminology as encountered
    • Use provided resources to support learning, research if needed

    Microbes, Antigens, Cytokines, Antibodies

    • Describe microbes, antigens, cytokines, and antibodies, along with examples.
    • Highlight different types of antibodies (IgA, IgD, IgE, IgG, IgM) and their functions.
    • Differentiate between the non-specific (innate) and adaptive (acquired) immunity.

    Phagocytes, Proteins, and Immune responses

    • Describe how phagocytes work and engulf pathogens.
    • Explain the role of proteins, such as antibodies and cytokines, in the immune system.
    • Describe the different types of immunity, innate and adaptive immunity, highlighting the characteristics of each.
    • Define opsonins and their role in phagocytosis.
    • Identify immune system protein types, antibodies, signaling proteins, complement proteins.
    • Detail IgG and IgM responses.

    Opsonins

    • Define opsonins.
    • Explain the role of substances in serum that promote phagocytosis of bacteria. (e.g. IgG antibody, C3b molecule).

    Phagocytosis

    • Define phagocytosis, describing the process by which certain cells ingest or engulf other cells or particles.

    Apoptosis

    • Explain apoptosis as a type of programmed cell death for unwanted or abnormal cells

    Antigen-Presenting Cells

    • Describe antigen-presenting cells' role in processing and presenting protein antigens in ways recognized by T-cell receptors on the cell's surface.

    Complement System

    • Explain the role of the complement system in the immune system response, including its function in host defense and inflammation.

    Cells of the Immune System

    • Describe the different types of cells (e.g., neutrophils, macrophages, eosinophils, basophils, mast cells, dendritic cells) in the innate immune system and their functions.
    • Describe the roles of specific cells in the adaptive immune system.

    Innate vs. Adaptive Immunity

    • Summarize the differences between innate and adaptive immunity in terms of specificity, time response, antigen dependence, and memory responses.

    Immune System Barriers

    • Describe the anatomical and physiological barriers of the innate immune system.
    • Provide examples of barriers in the oral cavity, such as the skin, mucous membranes, and temperature regulation.
    • Mention the role of chemical mediators for defense.
    • Provide specific examples of barriers present in the oral cavity, such as low pH and enzymes.
    • Discuss inflammation, including phagocytic cells' actions and cytokine release.
    • Identify chemokines and histamine roles in attracting immune cells to infection sites.

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