Immunology Quiz

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What is the function of the T cell receptor (TCR)?

To regulate cytokine production

To produce antibodies against pathogens

To signal T cells for activation (correct)

To directly recognize and bind antigen

Where do T cells develop from precursor cells?

Spleen

Bone marrow

Thymus (correct)

Liver

What determines the antigen specificity of a lymphocyte?

MHC molecules on the surface of other cells

DNA sequences encoding the variable regions of the TCR (correct)

RNA sequences encoding the constant regions of the TCR

Protein expression levels in the thymus

What is the distinctive feature of T cells in terms of antigen recognition?

Recognizing short peptide fragments of pathogen’s protein antigens bound to MHC molecules Signup and view all the answers

What is the structure of the T cell receptor (TCR)?

Consists of α and β polypeptide chains linked by a disulphide bond Signup and view all the answers

How many identical antigen receptor molecules does each T cell bear on its surface?

Approximately 30,000 Signup and view all the answers

What is the similarity in structure between the α:β heterodimer of TCR and antibodies?

Similar in structure to Fab fragment of Ab Signup and view all the answers

How many binding sites does the T cell receptor (TCR) have?

One Signup and view all the answers

What is the primary location for T cell receptor (TCR) testing for antigen-recognition properties?

Immediate environment Signup and view all the answers

What is the main function of the T cell receptor (TCR) in recognizing antigen?

Recognizes short peptide fragments of pathogen’s protein antigens Signup and view all the answers

What is the relationship between T cell receptor (TCR) and antibody molecules?

Closely related Signup and view all the answers

What is the only function of the T cell receptor (TCR)?

To signal T cells for activation Signup and view all the answers

What is the role of the short hinge region in the T cell receptor (TCR) structure?

It contains a cysteine residue that forms the disulphide link between the 2 chains Signup and view all the answers

What distinguishes CD4 helper T cells from CD8 cytotoxic T cells?

Expression of cell surface proteins CD4, CD8 Signup and view all the answers

What is the consequence of CD4/8 binding alone to MHC?

No signal Signup and view all the answers

Which cells express little or no MHC1?

Non-nucleated cells Signup and view all the answers

What is the primary function of CD8 cytotoxic T cells?

Specialized to kill any cell they recognize Signup and view all the answers

Where are MHC2 molecules found?

Dendritic cells, B cells, and macrophages Signup and view all the answers

What is the consequence of T cells being alerted to all possible infections?

MHC molecules must be capable of binding stably to many different peptides Signup and view all the answers

What is the primary role of CD4 helper T cells in the immune response?

Stimulate antibody production Signup and view all the answers

What is the consequence of stable binding of peptides to MHC molecules?

Stability of bound peptides is very important Signup and view all the answers

What is the ligand recognized by the TCR?

Complex of peptide and MHC molecule Signup and view all the answers

What is the function of the hydrophobic transmembrane domain in the TCR structure?

Anchors the TCR in the cell membrane Signup and view all the answers

What is the role of CD4/8 in enhancing the sensitivity of the cell to antigen presented by MHC?

Deliver a kinase close to the signaling components of the TCR complex Signup and view all the answers

What is the function of the short hinge region in the T cell receptor (TCR) structure?

It contains a cysteine residue that forms the disulphide link between the 2 chains Signup and view all the answers

Where are MHC2 molecules found?

Dendritic cells, B cells, and macrophages Signup and view all the answers

What is the consequence of CD4/8 binding alone to MHC?

No signal is generated Signup and view all the answers

What is the distinctive feature of T cells in terms of antigen recognition?

They recognize short amino acid sequences of proteins Signup and view all the answers

What is the consequence of stable binding of peptides to MHC molecules?

No signal is generated Signup and view all the answers

What is the role of CD4/8 in enhancing the sensitivity of the cell to antigen presented by MHC?

They interact with an thyrosine kinase in the cytoplasm and can deliver this kinase close to the signaling components of the TCR complex Signup and view all the answers

What is the consequence for plasmodium species due to non-nucleated cells expressing little or no MHC1?

They live undetected in red blood cells Signup and view all the answers

What is the primary location for T cell receptor (TCR) testing for antigen-recognition properties?

Amino terminal variable (V) region Signup and view all the answers

What is the consequence of T cells being alerted to all possible infections?

They must be capable of binding stably to many different peptides Signup and view all the answers

What is the role of the hydrophobic transmembrane domain in the TCR structure?

It anchors the TCR in the cell membrane Signup and view all the answers

Immunology Quiz

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Questions and Answers

What is the function of the T cell receptor (TCR)?

Where do T cells develop from precursor cells?

What determines the antigen specificity of a lymphocyte?

What is the distinctive feature of T cells in terms of antigen recognition?

What is the structure of the T cell receptor (TCR)?

How many identical antigen receptor molecules does each T cell bear on its surface?

What is the similarity in structure between the α:β heterodimer of TCR and antibodies?

How many binding sites does the T cell receptor (TCR) have?

What is the primary location for T cell receptor (TCR) testing for antigen-recognition properties?

What is the main function of the T cell receptor (TCR) in recognizing antigen?

What is the relationship between T cell receptor (TCR) and antibody molecules?

What is the only function of the T cell receptor (TCR)?

What is the role of the short hinge region in the T cell receptor (TCR) structure?

What distinguishes CD4 helper T cells from CD8 cytotoxic T cells?

What is the consequence of CD4/8 binding alone to MHC?

Which cells express little or no MHC1?

What is the primary function of CD8 cytotoxic T cells?

Where are MHC2 molecules found?

What is the consequence of T cells being alerted to all possible infections?

What is the primary role of CD4 helper T cells in the immune response?

What is the consequence of stable binding of peptides to MHC molecules?

What is the ligand recognized by the TCR?

What is the function of the hydrophobic transmembrane domain in the TCR structure?

What is the role of CD4/8 in enhancing the sensitivity of the cell to antigen presented by MHC?

What is the function of the short hinge region in the T cell receptor (TCR) structure?

Where are MHC2 molecules found?

What is the consequence of CD4/8 binding alone to MHC?

What is the distinctive feature of T cells in terms of antigen recognition?

What is the consequence of stable binding of peptides to MHC molecules?

What is the role of CD4/8 in enhancing the sensitivity of the cell to antigen presented by MHC?

What is the consequence for plasmodium species due to non-nucleated cells expressing little or no MHC1?

What is the primary location for T cell receptor (TCR) testing for antigen-recognition properties?

What is the consequence of T cells being alerted to all possible infections?

What is the role of the hydrophobic transmembrane domain in the TCR structure?

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