28 Questions
Which type of cells recognize peptide Major Histocompatibility Complex (pMHC) Class II complexes?
Th cells
Where do mature B cells express IgM and IgD surface immunoglobulins?
Bone marrow
Which type of cells differentiate into plasma cells upon stimulation?
B cells
What do Natural Killer (NK) cells lack on their surface?
T cell & B cell surface markers
Which type of lymphocytes are key players in the adaptive immune response and participate in regulating other cells?
Th cells
Where do T-cells migrate from in order to mature and develop T-cell receptors (TCRs)?
Bone marrow
Which lymphocytes are restricted to recognition of peptide Major Histocompatibility Complex (pMHC) Class I complexes?
Tc cells
What is a characteristic feature of plasma cells?
Synthesize and display Ig of only one antibody specificity on their surface
Which of the following statements about B cell education in the bone marrow is correct?
Self-reactive B cells undergo apoptosis to prevent autoimmunity.
What is the primary function of secondary lymphoid tissues and organs?
Allowing cellular interactions and exposure to antigens.
Which of the following statements about the spleen is incorrect?
The spleen is responsible for T cell education.
What changes in red blood cell (RBC) morphology would be observed in peripheral blood after spleen rupture or splenectomy (spleen removal)?
Presence of spherocytes (spherical RBCs).
Which of the following statements about lymph nodes is correct?
Lymph nodes are located along the lymphatic vessels.
Which of the following is the largest secondary lymphoid organ?
Spleen
What is the role of the cortex and medulla in lymph nodes?
Both the cortex and medulla are sites for initiating immune responses.
Which of the following statements about the lymphatic system is correct?
Lymphatic vessels transport lymph fluid away from tissues and organs.
Which of the following statements about mucosa-associated lymphoid tissue (MALT) is correct?
MALT includes structures like tonsils and Peyer's patches.
What is the primary function of lymph nodes?
Filtering lymph and initiating immune responses.
Which of the following statements about T cell receptor (TCR) and B cell receptor (BCR) development is correct?
They develop in the bone marrow
Which of the following statements about natural killer (NK) cells and natural killer T (NKT) cells is incorrect?
They develop in the bone marrow
What is the primary function of killer-activating receptors (KARs) on NK and NKT cells?
To recognize and bind to stress molecules on virally-infected or malignant host cells
Which of the following statements about primary lymphoid organs is incorrect?
They are where immune cells interact and encounter antigens
What is the primary function of the thymus in T cell development?
To educate T cells to distinguish self from non-self antigens
Which of the following statements about positive selection in the thymus is correct?
It ensures that T cells can recognize self MHC molecules
What is the purpose of negative selection in the thymus?
To eliminate T cells that can strongly recognize self-antigens
Which of the following statements about secondary (peripheral) lymphoid organs is correct?
They are sites where immune cells interact, encounter antigens, and respond to threats
Which of the following is a characteristic of mature T cells that have successfully completed the selection processes in the thymus?
They express either CD4 or CD8 molecules, but not both
The text compares the selection processes in the thymus to the training of which elite military group?
Marine Corps
Test your knowledge on lymphoid cells, Thymus-derived cells, Bone-marrow derived cells, and how the Adaptive Immune System distinguishes self from non-self using TCRs and BCRs. This quiz covers lecture content from Lectures #10 to #15, specifically focusing on Chapter 7 - Lymphoid Cells.
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