Lymphatic System and Immunology Quiz
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Questions and Answers

What is the primary function of lymphatic capillaries?

  • To produce white blood cells for the immune system
  • To filter waste products from the blood
  • To transport oxygenated blood from the lungs to the rest of the body
  • To collect excess interstitial fluid and return it to the bloodstream (correct)
  • Which of the following is NOT a characteristic of lymphatic vessels?

  • They are responsible for returning lost plasma proteins to the blood
  • They transport blood throughout the body (correct)
  • They have valves that prevent backflow
  • They have thinner walls than veins
  • What is the role of lymph nodes in the lymphatic system?

  • To produce red blood cells for oxygen transport
  • To filter lymph and remove foreign substances, such as bacteria (correct)
  • To store and release hormones
  • To regulate blood pressure
  • How does the lymphatic system contribute to the cardiovascular system?

    <p>By collecting excess fluid and returning it to the bloodstream (C)</p> Signup and view all the answers

    Which of the following is a mechanism that assists the flow of lymph?

    <p>Skeletal muscle contractions (A)</p> Signup and view all the answers

    What is the primary role of T cells in the immune response?

    <p>Manage the immune response and attack foreign cells (D)</p> Signup and view all the answers

    Which of the following defines an antigen?

    <p>Any substance the body perceives as foreign (C)</p> Signup and view all the answers

    Which statement about secondary lymphatic organs is correct?

    <p>They are the primary sites where most immune responses occur. (C)</p> Signup and view all the answers

    What function do dendritic cells perform in the immune system?

    <p>Activate T cells and capture antigens (B)</p> Signup and view all the answers

    Which type of lymphoid cell aids in the activation of T cells by phagocytizing foreign substances?

    <p>Macrophages (C)</p> Signup and view all the answers

    What is the primary function of macrophages in the red pulp of the spleen?

    <p>To remove ruptured, worn-out, or defective blood cells (C)</p> Signup and view all the answers

    Which type of pulp in the spleen is primarily involved in immune function through lymphocytes?

    <p>White pulp (D)</p> Signup and view all the answers

    Which of the following statements about the spleen's functions is false?

    <p>The spleen produces blood cells throughout a person's life. (B)</p> Signup and view all the answers

    How much of the body's platelet supply can the spleen store?

    <p>Up to 33% (B)</p> Signup and view all the answers

    Which component is NOT part of the stroma of the spleen?

    <p>B lymphocytes (C)</p> Signup and view all the answers

    Which of the following is NOT a component of the lymphatic system?

    <p>Blood vessels (B)</p> Signup and view all the answers

    What is the primary function of the lymphatic system?

    <p>Draining excess interstitial fluid and transporting dietary lipids (A)</p> Signup and view all the answers

    What differentiates innate immunity from adaptive immunity?

    <p>Innate immunity does not have a memory component, while adaptive immunity does. (C)</p> Signup and view all the answers

    Which of the following is an example of an innate immune defense mechanism?

    <p>Inflammation (C)</p> Signup and view all the answers

    How does the lymphatic system contribute to the adaptive immune response?

    <p>By transporting white blood cells to sites of infection (D)</p> Signup and view all the answers

    What is the primary function of neutrophils during the immune response?

    <p>To perform phagocytosis to destroy microbes (C)</p> Signup and view all the answers

    How do monocytes contribute to the immune response?

    <p>By becoming macrophages that are more potent than neutrophils (C)</p> Signup and view all the answers

    What distinguishes adaptive immunity from innate immunity?

    <p>Specificity and memory against antigens (A)</p> Signup and view all the answers

    Where do B cells complete their development?

    <p>In the red bone marrow (B)</p> Signup and view all the answers

    What type of antigens are cytotoxic T cells particularly effective against?

    <p>Intracellular pathogens, including viruses and bacteria (A)</p> Signup and view all the answers

    Which type of immunity involves B cells transforming into plasma cells?

    <p>Antibody-mediated immunity (B)</p> Signup and view all the answers

    Which cells primarily attack cells in cell-mediated immunity?

    <p>Cytotoxic T cells (C)</p> Signup and view all the answers

    What is pus primarily composed of?

    <p>A mix of dead phagocytes and damaged tissue (A)</p> Signup and view all the answers

    What is the primary role of complement proteins in the immune system?

    <p>Enhance immune reactions and cause cytolysis (B)</p> Signup and view all the answers

    Which of the following proteins is NOT known for its iron-binding ability?

    <p>Hemoglobin (A)</p> Signup and view all the answers

    What is the main function of antimicrobial proteins (AMPs)?

    <p>Exhibit broad antimicrobial activity (D)</p> Signup and view all the answers

    Which type of cell is classified as a natural killer (NK) cell?

    <p>Lymphocyte (A)</p> Signup and view all the answers

    What are the five steps involved in phagocytosis?

    <p>Chemotaxis, adherence, ingestion, digestion, killing (A)</p> Signup and view all the answers

    Which of the following is NOT a sign or symptom of inflammation?

    <p>Fever (D)</p> Signup and view all the answers

    What process follows vasodilation during inflammation?

    <p>Emigration of phagocytes (D)</p> Signup and view all the answers

    What mediators increase the permeability of blood vessels during inflammation?

    <p>Histamine and prostaglandins (C)</p> Signup and view all the answers

    What is the main role of neutrophils in the phagocytosis process?

    <p>Engulf pathogens (A)</p> Signup and view all the answers

    What is the ultimate goal of inflammation?

    <p>Eliminate pathogens and begin repair (A)</p> Signup and view all the answers

    Which type of lymphoid cell plays a significant role in managing the immune response by attacking and destroying foreign cells?

    <p>T cells (A)</p> Signup and view all the answers

    Which of the following is NOT a primary lymphatic organ?

    <p>Lymph nodes (A), Spleen (D)</p> Signup and view all the answers

    Which cells are responsible for producing antibodies that immobilize antigens?

    <p>Plasma cells (B)</p> Signup and view all the answers

    Which type of lymphoid cell shares a similar function with macrophages in terms of capturing antigens and transporting them to lymph nodes?

    <p>Dendritic cells (C)</p> Signup and view all the answers

    Which of the following best describes the function of reticular cells within lymphoid organs?

    <p>Providing structural support for other cells (B)</p> Signup and view all the answers

    Which of the following accurately describes the role of neutrophils in the early stages of inflammation?

    <p>Neutrophils are the dominant cell type, but their lifespan is short. (D)</p> Signup and view all the answers

    What is the primary difference between innate and adaptive immunity?

    <p>Innate immunity is a nonspecific defense, while adaptive immunity is specific. (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of adaptive immunity?

    <p>It is the body's first line of defense. (A)</p> Signup and view all the answers

    Which of the following accurately describes the role of helper T cells in the immune response?

    <p>Helper T cells play a role in both cell-mediated and antibody-mediated immunity. (C)</p> Signup and view all the answers

    Which of the following accurately describes the relationship between cell-mediated immunity and antibody-mediated immunity?

    <p>Cell-mediated immunity targets intracellular pathogens, while antibody-mediated immunity targets extracellular pathogens. (C)</p> Signup and view all the answers

    What is the primary function of macrophages in the immune response?

    <p>To engulf and destroy pathogens through phagocytosis. (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of pus?

    <p>It contains only dead pathogens, not host tissue. (B)</p> Signup and view all the answers

    Which of the following is a key characteristic of immunocompetence?

    <p>The ability to recognize and respond to specific antigens. (D)</p> Signup and view all the answers

    What is the primary function of the skin and mucous membranes as part of the first line of defense in innate immunity?

    <p>To provide a physical and chemical barrier against pathogens (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the first line of defense in innate immunity?

    <p>It is specific to particular pathogens (A)</p> Signup and view all the answers

    Which of the following is a primary function of interferons in the second line of defense?

    <p>Preventing viral replication in neighboring cells (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the second line of defense in innate immunity?

    <p>It is specific to particular pathogens (A)</p> Signup and view all the answers

    Which of the following is a chemical barrier that contributes to the first line of defense in innate immunity?

    <p>Lysozyme in tears (A)</p> Signup and view all the answers

    Which internal defense mechanism relies on the production of proteins that interfere with viral replication in neighboring cells?

    <p>Interferons (D)</p> Signup and view all the answers

    Which of the following is NOT an example of a physical barrier in the first line of defense?

    <p>Lysozyme in tears (A)</p> Signup and view all the answers

    Which of the following accurately describes the role of the second line of defense in innate immunity?

    <p>To provide a general, nonspecific defense against a wide range of pathogens (D)</p> Signup and view all the answers

    Which of the following components of the spleen is responsible for immune function, specifically housing lymphocytes and macrophages?

    <p>White pulp (A)</p> Signup and view all the answers

    The spleen's role in the removal of ruptured, worn-out, or defective blood cells is primarily attributed to which type of cell?

    <p>Macrophages (A)</p> Signup and view all the answers

    The spleen's ability to store up to one-third of the body's platelet supply is a significant function contributing to:

    <p>Hemostasis (A)</p> Signup and view all the answers

    Which of these functions is NOT a primary role of the spleen?

    <p>Production of red blood cells in adults (B)</p> Signup and view all the answers

    The spleen's structure is composed of two main parts: the parenchyma and the stroma. What is the function of the stroma?

    <p>Supporting the parenchyma, providing structural framework (B)</p> Signup and view all the answers

    What is the primary role of antigen-presenting cells (APCs) in the immune response?

    <p>They process and present antigens to T cells. (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of exogenous antigens?

    <p>They are displayed on the surface of cells in association with MHC-I molecules. (D)</p> Signup and view all the answers

    What is the role of costimulation in the activation of T cells?

    <p>It ensures that T cells are only activated when a genuine threat exists. (D)</p> Signup and view all the answers

    Which type of T cell is responsible for directly attacking cells infected with viruses or other intracellular pathogens?

    <p>Cytotoxic T cells (CD8+ T cells) (B)</p> Signup and view all the answers

    Which of the following mechanisms does NOT directly contribute to the killing of infected cells by cytotoxic T cells?

    <p>Secretion of antibodies that neutralize the pathogen. (B)</p> Signup and view all the answers

    What is the primary function of plasma cells in the immune response?

    <p>They secrete antibodies. (D)</p> Signup and view all the answers

    Which of the following is NOT a way that antibodies contribute to the inactivation or elimination of pathogens?

    <p>Directly killing infected cells through the release of cytotoxic molecules. (A)</p> Signup and view all the answers

    What is the role of memory cells in adaptive immunity?

    <p>They provide a rapid and robust response upon re-exposure to the same pathogen. (D)</p> Signup and view all the answers

    Which of the following statements accurately describes the difference between cell-mediated and antibody-mediated immunity?

    <p>Cell-mediated immunity involves the direct killing of infected cells, while antibody-mediated immunity primarily targets pathogens in body fluids. (A)</p> Signup and view all the answers

    What is the role of interleukin-2 (IL-2) in the immune response?

    <p>It acts as a costimulator for the activation of both T and B cells. (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the variable (V) region of an antibody?

    <p>It determines the class of the antibody. (D)</p> Signup and view all the answers

    Which of the following is a potential consequence of an immune system that fails to distinguish self from non-self?

    <p>Development of autoimmune diseases. (A)</p> Signup and view all the answers

    Which of the following correctly describes the sequence of events involved in antigen processing and presentation by APCs?

    <p>Antigen uptake, antigen digestion, MHC-II synthesis, antigen-MHC-II complex formation, presentation on cell surface. (B)</p> Signup and view all the answers

    Which of the following cells does NOT undergo clonal selection during the adaptive immune response?

    <p>Natural killer (NK) cells (A)</p> Signup and view all the answers

    Which of the following scenarios most accurately describes the role of memory T cells in protecting against reinfection?

    <p>Memory T cells quickly differentiate into effector T cells upon re-exposure to the same pathogen. (C)</p> Signup and view all the answers

    Which of the following correctly describes the flow of lymph through a lymph node?

    <p>Lymph flows through the node in a unidirectional way, entering via afferent vessels and exiting through efferent vessels. (C)</p> Signup and view all the answers

    What is the primary role of the lymph node's cortex in immune function?

    <p>Generating plasma cells and memory B cells in response to antigens. (A)</p> Signup and view all the answers

    Which of the following is NOT a component of the stroma of a lymph node?

    <p>Lymphatic nodules (B)</p> Signup and view all the answers

    What is the primary function of dendritic cells in the lymph node?

    <p>To activate T cells by presenting antigens to them. (D)</p> Signup and view all the answers

    Where are T cells primarily located within the lymph node?

    <p>Inner cortex (B)</p> Signup and view all the answers

    Which of the following accurately describes the relationship between lymph nodes and the lymphatic stream?

    <p>Lymph nodes are part of the lymphatic stream, acting as filters along its pathway. (A)</p> Signup and view all the answers

    What is the primary function of medullary sinuses within a lymph node?

    <p>Collecting lymph, antibodies, and activated T cells before draining into efferent vessels. (D)</p> Signup and view all the answers

    Which of the following statements accurately explains the relationship between lymph nodes and immune system activation?

    <p>Lymph nodes provide a central location for monitoring for antigens and launching immune responses against them. (D)</p> Signup and view all the answers

    What is the primary structural feature that defines the medulla of a lymph node?

    <p>B cells and antibody-producing plasma cells (C)</p> Signup and view all the answers

    Which component surrounds and supports the structure of a lymph node?

    <p>Stroma (A)</p> Signup and view all the answers

    In which part of the lymph node do plasma cells primarily develop?

    <p>Outer cortex (A)</p> Signup and view all the answers

    What is the direction of lymph flow through a lymph node?

    <p>From afferent lymphatic vessels into sinuses (C)</p> Signup and view all the answers

    What role do macrophages play in the lymph nodes?

    <p>Destroy foreign substances (B)</p> Signup and view all the answers

    Which cells predominantly reside in the inner cortex of a lymph node?

    <p>T cells (A)</p> Signup and view all the answers

    What component of lymph nodes helps in dividing the node into different compartments?

    <p>Trabeculae (A)</p> Signup and view all the answers

    Which of the following is NOT a function of the lymphatic system?

    <p>Filter blood and remove old red blood cells (B)</p> Signup and view all the answers

    What are the two basic functions of lymph nodes?

    <p>Filtration and immune surveillance (B)</p> Signup and view all the answers

    What is the key difference between innate and adaptive immunity?

    <p>Adaptive immunity has a memory component and can recognize specific invaders, while innate immunity does not. (C)</p> Signup and view all the answers

    Which of the following structures is NOT part of the lymphatic system?

    <p>Pancreas (B)</p> Signup and view all the answers

    What is the primary function of lymph nodes in the lymphatic system?

    <p>To store and filter lymph fluid (A)</p> Signup and view all the answers

    Which of the following is a characteristic of lymphatic nodules?

    <p>They are part of the mucosa-associated lymphatic tissue (MALT) (C)</p> Signup and view all the answers

    What are the first line of defenses against pathogens?

    <p>Skin and mucous membranes (D)</p> Signup and view all the answers

    What role do cilia of the upper respiratory tract play in innate immunity?

    <p>They expel mucus and foreign particles from the respiratory tract (C)</p> Signup and view all the answers

    What type of substances do interferons prevent from replicating in neighboring cells?

    <p>Viruses (C)</p> Signup and view all the answers

    Which of the following is NOT a chemical barrier of the innate immune system?

    <p>Skin barrier provided by epithelial cells (C)</p> Signup and view all the answers

    Which bodily fluid is NOT involved in washing away potential pathogens as part of the immune defense?

    <p>Blood (D)</p> Signup and view all the answers

    What is the role of mucus in the innate immune system?

    <p>It traps microbes and foreign substances (C)</p> Signup and view all the answers

    Which of the following components plays a crucial role in enhancing the cleansing process of the urinary tract?

    <p>Urine (A)</p> Signup and view all the answers

    What is the essential function of anchoring filaments in lymphatic capillaries?

    <p>They widen capillary openings to allow entry of interstitial fluid. (C)</p> Signup and view all the answers

    Which of the following accurately describes the relationship between the lymphatic and cardiovascular systems?

    <p>The lymphatic system returns excess fluid and proteins from interstitial spaces back to the blood. (D)</p> Signup and view all the answers

    What is the primary mechanism responsible for the movement of lymph through the lymphatic vessels?

    <p>The combined actions of skeletal muscle contractions and respiratory movements. (C)</p> Signup and view all the answers

    Which of the following are the two main channels that lymph passes through before draining into venous blood?

    <p>Thoracic duct and right lymphatic duct. (D)</p> Signup and view all the answers

    What is the primary reason why a larger volume of fluid filters out of blood capillaries than returns to them by reabsorption?

    <p>The osmotic pressure of blood is higher than the osmotic pressure of interstitial fluid due to the presence of plasma proteins. (C)</p> Signup and view all the answers

    What does clonal selection primarily induce in lymphocytes?

    <p>Dividing into identical cells responding to the same antigen (C)</p> Signup and view all the answers

    What is the function of memory cells in the immune response?

    <p>They produce antibodies during subsequent exposures (D)</p> Signup and view all the answers

    Which characteristic allows an antigen to trigger an immune response?

    <p>Immunogenicity (B)</p> Signup and view all the answers

    What role do epitopes play in the immune system?

    <p>They trigger immune reactions by being recognized (D)</p> Signup and view all the answers

    In what locations does clonal selection primarily occur?

    <p>Secondary lymphatic tissues and organs (A)</p> Signup and view all the answers

    Which type of T cells are primarily responsible for orchestrating the immune response?

    <p>Helper T cells (B)</p> Signup and view all the answers

    What is the purpose of Major Histocompatibility Complex (MHC) Antigens?

    <p>To help T cells recognize self or foreign substances (C)</p> Signup and view all the answers

    What happens to effector cells after an immune response?

    <p>They are eliminated after the immune response is over (A)</p> Signup and view all the answers

    What is the primary function of complement proteins in the immune system?

    <p>Enhance certain immune reactions (A)</p> Signup and view all the answers

    Which of the following proteins is not classified as an iron-binding protein?

    <p>Cytochrome (D)</p> Signup and view all the answers

    What role do antimicrobial proteins (AMPs) play in the immune system?

    <p>Recognize and destroy harmful microbes (C)</p> Signup and view all the answers

    What is the function of natural killer (NK) cells in the immune response?

    <p>Kill infected and tumor cells directly (B)</p> Signup and view all the answers

    Which process follows chemotaxis in the phagocytosis of microbes?

    <p>Adherence of phagocytes to microorganisms (D)</p> Signup and view all the answers

    What is NOT a sign or symptom of inflammation?

    <p>Excessive thirst (C)</p> Signup and view all the answers

    What do phagocytes do during the emigration phase of inflammation?

    <p>Move towards the site of injury or infection (C)</p> Signup and view all the answers

    What occurs during the tissue repair stage of inflammation?

    <p>Formation of new tissue and healing (A)</p> Signup and view all the answers

    Which component of inflammation helps to increase blood vessel permeability?

    <p>Histamine (C)</p> Signup and view all the answers

    Which of the following describes the role of digested enzymes in phagocytosis?

    <p>Break down ingested material within phagocytes (B)</p> Signup and view all the answers

    Flashcards

    Immunity

    The ability to ward off disease through defenses.

    Innate Immunity

    Nonspecific immunity present at birth without memory.

    Adaptive Immunity

    Specific immunity that recognizes invaders and has a memory component.

    Lymphatic System

    Consists of lymph, vessels, and organs with lymphatic tissue.

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    Functions of Lymphatic System

    1. Drains excess fluid 2. Transports dietary lipids.
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    Lymphatic capillaries

    Small vessels that begin the lymphatic system, absorbing interstitial fluid.

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    Lymph trunks

    Large vessels formed by the union of lymphatic capillaries; they carry lymph to ducts.

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    Lymphatic vessels

    Thin-walled vessels similar to veins but with more valves that transport lymph towards the heart.

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    Formation of lymph

    The process where excess filtered fluid from blood capillaries drains into lymphatic vessels and becomes lymph.

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    Lymphatic system function

    Returns lost plasma proteins to blood; important for fluid balance and immune response.

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    Spleen

    Largest single mass of lymphatic tissue in the body.

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    White Pulp

    Part of the spleen containing lymphatic tissue with lymphocytes and macrophages.

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    Red Pulp

    Blood-filled part of the spleen involved in filtering and storage.

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    Functions of Spleen

    Site of lymphocyte proliferation, immune response, and blood cleansing.

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    Macrophages in Spleen

    Cells that remove defective blood cells and recycle materials like iron.

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    Lymphocytes

    Main cells involved in the immune response, including T cells and B cells.

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    Antigen

    Any substance the body recognizes as foreign, like bacteria, viruses, or cancer cells.

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    T cells

    Type of lymphocyte that manages immune response and attacks foreign cells.

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    B cells

    Lymphocytes that produce plasma cells to secrete antibodies.

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    Primary lymphatic organs

    Sites where stem cells become immunocompetent, including red bone marrow and thymus.

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    Complement proteins

    Proteins in blood that enhance immune reactions and cause cell lysis.

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    Iron-binding proteins

    Proteins that inhibit bacterial growth by sequestering iron.

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    Transferrin

    An iron-binding protein found in blood and tissue fluids.

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    Antimicrobial peptides (AMPs)

    Short peptides that have broad antimicrobial activity and attract immune cells.

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    Natural Killer (NK) cells

    Lymphocytes that kill infected and tumor cells by destroying their membranes.

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    Phagocytosis

    Process where phagocytes engulf and digest microbes in five steps.

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    Steps in phagocytosis

    Includes chemotaxis, adherence, ingestion, digestion, and killing of microbes.

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    Inflammation

    Nonspecific response to tissue damage involving redness, heat, swelling, and pain.

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    Vasodilation

    Expansion of blood vessels to increase blood flow and allow immune substances to escape.

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    Phagocyte emigration

    The movement of phagocytes to the site of inflammation, starting with neutrophils.

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    Emigration

    The process of neutrophils squeezing through blood vessel walls to reach damaged cells.

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    Chemotaxis

    Movement of cells toward a chemical signal, guiding neutrophils to infection sites.

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    Macrophages

    Transformed monocytes that are more potent than neutrophils and engulf pathogens.

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    Pus

    A pocket of dead phagocytes and damaged tissue resulting from infections.

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    Immunocompetence

    The ability of immune cells to perform their adaptive immune functions.

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    Cell-mediated immunity

    Immunity where cytotoxic T cells attack invading antigens directly.

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    Antibody-mediated immunity

    B cells transform into plasma cells that produce antibodies to fight extracellular pathogens.

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    Spleen Structure

    Contains stroma and parenchyma with white and red pulp.

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    Spleen Macrophages

    Remove defective blood cells and recycle iron for reuse.

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    Lymph Node Structure

    Lymph nodes consist of cortex and medulla, surrounded by a fibrous capsule.

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    Cortex of Lymph Node

    The outer region of a lymph node containing B cell follicles and germinal centers.

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    Medulla of Lymph Node

    The inner region of a lymph node with B cells, plasma cells, and macrophages.

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    Functions of Lymph Nodes

    They filter foreign substances and activate immune responses.

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    Afferent Lymphatic Vessels

    Vessels that bring lymph into a lymph node.

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    Efferent Lymphatic Vessels

    Vessels that carry lymph away from a lymph node.

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    Lymph Flow Direction

    Lymph flows through nodes in one direction only, from afferent to efferent.

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    Lymph Node Stroma

    Supporting connective tissue including capsule, trabeculae, and reticular fibers.

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    Lymphatic Nodules

    Small aggregations of lymphatic tissue not surrounded by a capsule, found in mucosal membranes.

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    Mucosa-associated Lymphatic Tissue (MALT)

    Lymphatic tissue associated with mucous membranes in various systems, including respiratory and digestive tracts.

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    Physical Barriers (Innate Immunity)

    First line of defense against pathogens, including skin and mucous membranes that block entry.

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    Sebaceous Glands

    Glands that secrete sebum, forming an acid film on skin to protect against bacteria.

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    Interferons

    Proteins produced by infected cells that prevent virus replication in neighboring cells.

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    Cilia in Respiratory Tract

    Hair-like structures that move trapped particles up and out of the airway.

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    Mucous Role in Immunity

    Mucus traps microbes and foreign particles, preventing them from entering the body.

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    Chemical Barriers in the Body

    Substances like gastric juice and vaginal secretions that discourage bacterial growth due to acidity.

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    Neutrophil emigration

    Neutrophils squeezing through blood vessel walls to reach damage.

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    Monocytes

    Immune cells that transform into macrophages, more potent than neutrophils.

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    T cells maturation

    T cells develop from stem cells in bone marrow, then move to the thymus.

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    Antigen Processing

    The breakdown of antigenic proteins into peptide fragments associated with MHC molecules for presentation.

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    Antigen Presentation

    The insertion of antigen-MHC complexes into the plasma membrane for T cell recognition.

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    Exogenous Antigens

    Antigens that are present in fluid outside body cells and processed by APCs for T cell recognition.

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    Endogenous Antigens

    Antigens found inside body cells that are presented to T cells via MHC-I molecules.

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    Antigen-Presenting Cells (APCs)

    Cells like dendritic cells, macrophages, and B cells that process and present antigens to T cells.

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    T Cell Activation

    Requires T-cell receptor recognition of antigens presented by MHC complexes along with costimulation.

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    Clonal Selection of T Cells

    The process where activated T cells proliferate to form clones that fight the specific antigen.

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    Helper T Cells

    CD4+ T cells that assist in activating B cells and cytotoxic T cells by releasing cytokines.

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    Cytotoxic T Cells

    CD8+ T cells that directly kill infected body cells displaying antigens with MHC-I.

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    Memory T Cells

    Long-lived T cells that wait to respond rapidly upon re-exposure to the same antigen.

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    B Cell Activation

    Occurs when an antigen binds to B cell receptors and is presented with MHC-II after processing.

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    Production of Plasma Cells

    Activated B cells that secrete antibodies to fight infections, typically lasting 4-5 days.

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    Antibodies (Ig)

    Immunoglobulins produced by B cells that specifically bind to antigens.

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    Antibody Actions

    Functions like neutralization, immobilization, agglutination, and enhancing phagocytosis.

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    Costimulation

    Additional signals required for T cell activation, often involving cytokines like interleukin-2.

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    Lymphatic System Structure

    Composed of lymph, vessels, and organs with lymphatic tissue.

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    Red Bone Marrow

    Primary site for blood cell production and development of immune cells.

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    Lymph Nodes

    Encapsulated organs containing B and T cells that filter foreign substances and activate immune responses.

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    Skeletal Muscle Pump

    Mechanism aiding lymph flow, where muscle contractions help push lymph through vessels.

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    Stroma of Lymph Node

    Supporting connective tissue that includes capsule, trabeculae, and reticular fibers.

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    Parenchyma of Lymph Node

    The functional part of the lymph node, consisting of the cortex and medulla where immune activity occurs.

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    Outer Cortex

    Part of the lymph node containing B cells organized into lymphatic nodules, the site for their activation.

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    Inner Cortex

    Region of the lymph node primarily filled with T cells and dendritic cells that help activate immune responses.

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    Antimicrobial Substances

    Substances produced by the body, such as interferons, that help prevent infections.

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    Clonal Selection

    The process where lymphocytes proliferate and differentiate in response to a specific antigen.

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    Effector Cells

    Activated lymphocytes that actively help eliminate antigens, including T cells and plasma cells.

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    Antigen Characteristics

    Antigens provoke immune responses through immunogenicity and react specifically with antibodies.

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    Epitopes

    Specific parts of an antigen that trigger immune responses by binding to antibodies or T cells.

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    Major Histocompatibility Complex (MHC)

    Proteins that help T cells recognize self from non-self, crucial for immune responses.

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    Immunogenicity

    The ability of a substance to provoke an immune response.

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    Reactivity of Antigens

    The ability of an antigen to specifically interact with the antibodies it provokes.

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    Complement

    Proteins in blood that enhance immune reactions and cause cell lysis.

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    Antimicrobial Proteins (AMPs)

    Short peptides with broad-spectrum antimicrobial activity attracting immune cells.

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    Phagocytes

    Cells like neutrophils and macrophages that engulf and digest microbes.

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    Phagocytosis Steps

    Includes chemotaxis, adherence, ingestion, digestion, and killing.

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    Emigration of Phagocytes

    The movement of phagocytes like neutrophils to the site of inflammation.

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