10 Questions
What is the primary benefit of using induced pluripotent stem cell (iPSC) technology in humanized mice models?
Renewable source of cells without immune rejection
What is the consequence of absent or abnormal secondary lymphoid structures in humanized mice models?
Impaired humoral immune responses and class-switching and affinity maturation
How does engraftment with fetal liver cells improve immune cell reconstitution in humanized mice models?
Promotes HSCs differentiation and proliferation
What is the limitation of using lymphoid inducer cells in humanized mice models?
Affects the IL-2 receptor gamma chain
What is the purpose of introducing plasmids expressing cytokines into humanized mice?
To improve HSCs growth
What is the consequence of incomplete depletion of murine cells in humanized mice models?
Hinders the engraftment of human cells
What is the potential risk of depleting mouse RBCs in humanized mice models?
Anemic mice
What is a potential solution to improve human RBC engraftment in humanized mice models?
Improving human RBC engraftment
What is the role of IL-3 in humanized mice models?
Promotes HSCs growth and differentiation
What is the potential application of humanized mice models in sepsis diagnosis and treatment?
Development of epigenetic markers for early diagnosis and immune-boosting therapies
Test your knowledge of cytokines, specifically GM-CSF and IL-7, and their effects on T-lymphocyte function, including proliferation, maturation, and anti-apoptotic mechanisms.
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