Immunology Quiz: Cytokines and T-Lymphocyte Function
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Immunology Quiz: Cytokines and T-Lymphocyte Function

Test your knowledge of cytokines, specifically GM-CSF and IL-7, and their effects on T-lymphocyte function, including proliferation, maturation, and anti-apoptotic mechanisms.

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@ExultantOrbit

Questions and Answers

What is the primary benefit of using induced pluripotent stem cell (iPSC) technology in humanized mice models?

Renewable source of cells without immune rejection

What is the consequence of absent or abnormal secondary lymphoid structures in humanized mice models?

Impaired humoral immune responses and class-switching and affinity maturation

How does engraftment with fetal liver cells improve immune cell reconstitution in humanized mice models?

Promotes HSCs differentiation and proliferation

What is the limitation of using lymphoid inducer cells in humanized mice models?

<p>Affects the IL-2 receptor gamma chain</p> Signup and view all the answers

What is the purpose of introducing plasmids expressing cytokines into humanized mice?

<p>To improve HSCs growth</p> Signup and view all the answers

What is the consequence of incomplete depletion of murine cells in humanized mice models?

<p>Hinders the engraftment of human cells</p> Signup and view all the answers

What is the potential risk of depleting mouse RBCs in humanized mice models?

<p>Anemic mice</p> Signup and view all the answers

What is a potential solution to improve human RBC engraftment in humanized mice models?

<p>Improving human RBC engraftment</p> Signup and view all the answers

What is the role of IL-3 in humanized mice models?

<p>Promotes HSCs growth and differentiation</p> Signup and view all the answers

What is the potential application of humanized mice models in sepsis diagnosis and treatment?

<p>Development of epigenetic markers for early diagnosis and immune-boosting therapies</p> Signup and view all the answers

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