immunotherapy
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Questions and Answers

name 2 of the most common cytokines used in cancer therapy

interleukin 2 (IL-2)and interferon alpha

what is the function of interleukin-2

IL-2 is a cytokine that plays a critical role in the activation and proliferation of T cells which recognise and destroy cancer cells

what is the function of Interferon- alpha

IFN-a is used to stimulate the immune system antitumour response by enhancing the activity of immune cells like natural killer cells and cytotoxic T lymphocytes.

what is the function of interferons?

<p>activating the immune system and exerting anti-tumour effects</p> Signup and view all the answers

what is the main function of immune system modulators

<p>to activate the immune system and promote anti-tumour activity</p> Signup and view all the answers

describe the action of monoclonal antibodies in cancer therapy

<p>binding to a cell surface molecule (eg.CD20 on b ell tumours) on tumour cells, inducing apoptosis</p> Signup and view all the answers

how does adoptive t-cell therapy work?

<p>taking T-cells and making them more able to kill tumours by stimulating them in vitro then administering them back into the patient</p> Signup and view all the answers

how does CART therapy work?

<p>take blood from a patient, isolate the T cells, introduce a chimeric antigen receptor and grow these cells then administer them back into the patient</p> Signup and view all the answers

what two ways can T cells be switched off?

<p>in the tumour environment (PDL-1 and PD1) and in the environment where T cells are being stimulated by antigen-presenting cells</p> Signup and view all the answers

how do tumours switch off T cells? (2 ways)

<p>PDL-1 binds to PD-1 which switches off T cells. in lymph nodes CTLA-4 can bind proteins that switches off T cells.</p> Signup and view all the answers

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