10 Questions
name 2 of the most common cytokines used in cancer therapy
interleukin 2 (IL-2)and interferon alpha
what is the function of interleukin-2
IL-2 is a cytokine that plays a critical role in the activation and proliferation of T cells which recognise and destroy cancer cells
what is the function of Interferon- alpha
IFN-a is used to stimulate the immune system antitumour response by enhancing the activity of immune cells like natural killer cells and cytotoxic T lymphocytes.
what is the function of interferons?
activating the immune system and exerting anti-tumour effects
what is the main function of immune system modulators
to activate the immune system and promote anti-tumour activity
describe the action of monoclonal antibodies in cancer therapy
binding to a cell surface molecule (eg.CD20 on b ell tumours) on tumour cells, inducing apoptosis
how does adoptive t-cell therapy work?
taking T-cells and making them more able to kill tumours by stimulating them in vitro then administering them back into the patient
how does CART therapy work?
take blood from a patient, isolate the T cells, introduce a chimeric antigen receptor and grow these cells then administer them back into the patient
what two ways can T cells be switched off?
in the tumour environment (PDL-1 and PD1) and in the environment where T cells are being stimulated by antigen-presenting cells
how do tumours switch off T cells? (2 ways)
PDL-1 binds to PD-1 which switches off T cells. in lymph nodes CTLA-4 can bind proteins that switches off T cells.
Identify two commonly used cytokines in cancer treatment. Cytokines are signaling molecules that help regulate the immune response. In this quiz, you will learn about two essential cytokines used in cancer therapy.
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