lecture 14 multiple chocie quiz- immunology

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What is the role of cytokines in cellular processes?

Inhibiting proliferation and differentiation

Suppressing activation and inflammation

Activating migration and differentiation

Regulating gene expression in target cells (correct)

Which molecule interacts with CD80 and CD86 on APCs to provide a second signal for T cell activation?

CD3

CD4

CD28 (correct)

CD14

What happens if an antigen-presenting cell presents a self-antigen to a T cell without providing costimulatory signals?

T cell activation occurs immediately

The T cell becomes tolerant to the self-antigen (correct)

The T cell undergoes rapid proliferation

The T cell differentiates into a memory cell

Which scenario accurately describes the importance of costimulatory signals in T cell activation?

In the absence of costimulatory signals, T cell activation may not occur Signup and view all the answers

Which protein is expressed on the surface of T cells and is crucial for providing a second signal for T cell activation?

CD28 Signup and view all the answers

What is the role of cytokines in cellular processes?

Regulate gene expression in target cells Signup and view all the answers

Which molecule is crucial for T cell activation and expressed on the surface of T cells?

CD28 Signup and view all the answers

How does APC activation by microbes lead to T cell survival and proliferation?

Increasing costimulator expression Signup and view all the answers

Which molecule is responsible for enhancing the effector functions of T cells, such as survival and proliferation?

IL-2 Signup and view all the answers

What happens when an APC presents a self-antigen to a T cell without providing costimulatory signals?

The T cell becomes tolerant to the self-antigen Signup and view all the answers

What is the primary function of interleukin-2 (IL-2) in immune responses?

Promote T cell survival Signup and view all the answers

Which cells primarily produce interleukin-2 (IL-2) during immune responses?

CD4+ helper T cells Signup and view all the answers

What is the main function of costimulatory signals in APC-T cell interactions?

Enhance effector T cell differentiation Signup and view all the answers

Which process leads to APC activation in response to microbial products?

Antigen presentation Signup and view all the answers

What is the role of IL-2 signaling through its receptor (IL-2R) in T cell responses against pathogens?

Promoting T cell survival and expansion Signup and view all the answers

What is the role of CD28 in T cell activation?

It facilitates the interaction between TCR and antigen peptide. Signup and view all the answers

Which cytokine milieu and signals received during T cell activation determine the differentiation of CD4+ T cells into subsets like Th1, Th2, Th17, or Treg cells?

IL-6 Signup and view all the answers

Which of the following is a key function of effector T cells?

Effector cell differentiation Signup and view all the answers

What is the primary role of costimulatory molecules like CD80/CD86 in T cell activation?

Enhancing the interaction between T cells and APCs Signup and view all the answers

During which phase of T cell activation do activated T cells undergo rapid proliferation?

Clonal expansion Signup and view all the answers

Which type of T cells are activated by the MHC class I molecules presented by APCs?

Effector T cells Signup and view all the answers

What is the primary role of costimulatory signals in T cell activation?

Enhance T cell proliferation and differentiation Signup and view all the answers

Which of the following events typically occurs after the activation of macrophages in the T cell response?

Activation of B cells Signup and view all the answers

In the sequence of events in T cell responses, what is the main role of cytokines?

Direct effector functions like killing infected cells Signup and view all the answers

What is the significance of APCs expressing both MHC class I and MHC class II molecules during antigen presentation?

It facilitates priming of both CD4+ and CD8+ T cells Signup and view all the answers

Which type of T cells are presented with exogenous antigens by APCs?

CD4+ T cells Signup and view all the answers

What is the function of costimulators in T cell activation?

Provide the necessary signals for T cell activation Signup and view all the answers

Which cytokine typically 'tells' the responding cell to proliferate and differentiate into effector T cells?

IL-2 Signup and view all the answers

What is the main function of APCs in the context of T cell responses?

Present antigens to activate T cells Signup and view all the answers

During T cell activation, what type of T cells encounter APCs presenting antigens?

Naive T cells Signup and view all the answers

What is the primary role of IL-2 in T cell biology?

Stimulates T cell survival, proliferation, and differentiation into effector T cells Signup and view all the answers

Which of the following is NOT a proinflammatory cytokine mentioned in the text?

Interleukin-10 (IL-10) Signup and view all the answers

What effect does the upregulation of costimulatory molecules on APCs have on T cell activation?

Enhances T cell activation through costimulatory signals Signup and view all the answers

Which immune cells primarily produce interleukin-2 (IL-2)?

Activated T cells Signup and view all the answers

How do proinflammatory cytokines contribute to T cell activation?

Promote the expression of costimulatory molecules on APCs Signup and view all the answers

Which event immediately follows the activation of naive T cells by APCs presenting antigens?

Expression of interleukin-2 (IL-2) by T cells Signup and view all the answers

In the context of immune responses, what role do costimulatory molecules play?

Provide a crucial second signal for T cell activation Signup and view all the answers

What is the impact of IL-2 on effector T cells?

Enhances survival and effector functions of effector T cells Signup and view all the answers

Which statement best describes the relationship between IL-2 and APC activation by microbes?

Microbial pathogens can trigger innate immune responses leading to IL-2 production Signup and view all the answers

lecture 14 multiple chocie quiz- immunology

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Questions and Answers

What is the role of cytokines in cellular processes?

Which molecule interacts with CD80 and CD86 on APCs to provide a second signal for T cell activation?

What happens if an antigen-presenting cell presents a self-antigen to a T cell without providing costimulatory signals?

Which scenario accurately describes the importance of costimulatory signals in T cell activation?

Which protein is expressed on the surface of T cells and is crucial for providing a second signal for T cell activation?

What is the role of cytokines in cellular processes?

Which molecule is crucial for T cell activation and expressed on the surface of T cells?

How does APC activation by microbes lead to T cell survival and proliferation?

Which molecule is responsible for enhancing the effector functions of T cells, such as survival and proliferation?

What happens when an APC presents a self-antigen to a T cell without providing costimulatory signals?

What is the primary function of interleukin-2 (IL-2) in immune responses?

Which cells primarily produce interleukin-2 (IL-2) during immune responses?

What is the main function of costimulatory signals in APC-T cell interactions?

Which process leads to APC activation in response to microbial products?

What is the role of IL-2 signaling through its receptor (IL-2R) in T cell responses against pathogens?

What is the role of CD28 in T cell activation?

Which cytokine milieu and signals received during T cell activation determine the differentiation of CD4+ T cells into subsets like Th1, Th2, Th17, or Treg cells?

Which of the following is a key function of effector T cells?

What is the primary role of costimulatory molecules like CD80/CD86 in T cell activation?

During which phase of T cell activation do activated T cells undergo rapid proliferation?

Which type of T cells are activated by the MHC class I molecules presented by APCs?

What is the primary role of costimulatory signals in T cell activation?

Which of the following events typically occurs after the activation of macrophages in the T cell response?

In the sequence of events in T cell responses, what is the main role of cytokines?

What is the significance of APCs expressing both MHC class I and MHC class II molecules during antigen presentation?

Which type of T cells are presented with exogenous antigens by APCs?

What is the function of costimulators in T cell activation?

Which cytokine typically 'tells' the responding cell to proliferate and differentiate into effector T cells?

What is the main function of APCs in the context of T cell responses?

During T cell activation, what type of T cells encounter APCs presenting antigens?

What is the primary role of IL-2 in T cell biology?

Which of the following is NOT a proinflammatory cytokine mentioned in the text?

What effect does the upregulation of costimulatory molecules on APCs have on T cell activation?

Which immune cells primarily produce interleukin-2 (IL-2)?

How do proinflammatory cytokines contribute to T cell activation?

Which event immediately follows the activation of naive T cells by APCs presenting antigens?

In the context of immune responses, what role do costimulatory molecules play?

What is the impact of IL-2 on effector T cells?

Which statement best describes the relationship between IL-2 and APC activation by microbes?

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