Podcast
Questions and Answers
Which of the following is NOT considered a pathogen?
Which of the following is NOT considered a pathogen?
- Pollen (correct)
- Viruses
- Bacteria
- Parasites
Which category of substance includes interleukins and interferons?
Which category of substance includes interleukins and interferons?
- Pathogens
- Cytokines (correct)
- Toxins
- Antigens
Which of the following is best categorized as an antigen?
Which of the following is best categorized as an antigen?
- Colony stimulating factor (CSF)
- Interferon
- Lymphokine
- Toxin (correct)
What type of cells primarily produces Type-1 cytokines?
What type of cells primarily produces Type-1 cytokines?
Which is NOT a category of immune-related molecules?
Which is NOT a category of immune-related molecules?
Which of the following is an example of a chemical that can act as an antigen?
Which of the following is an example of a chemical that can act as an antigen?
What is the primary function of Colony Stimulating Factors (CSF)?
What is the primary function of Colony Stimulating Factors (CSF)?
Type-2 cytokines are produced by what type of cell?
Type-2 cytokines are produced by what type of cell?
Which of the following cells are classified as phagocytes?
Which of the following cells are classified as phagocytes?
Which of these is a primary function of complement proteins?
Which of these is a primary function of complement proteins?
Which of the following is NOT a type of signalling protein mentioned in the content?
Which of the following is NOT a type of signalling protein mentioned in the content?
What process is synonymous with programmed cell death?
What process is synonymous with programmed cell death?
Which of the following is an example of an antibody?
Which of the following is an example of an antibody?
A phagocyte directly engulfing a bacterium is best described as what process?
A phagocyte directly engulfing a bacterium is best described as what process?
Which type of immune cell is responsible for phagocytosing bacteria?
Which type of immune cell is responsible for phagocytosing bacteria?
Which substance facilitates the process of phagocytosis through opsonization?
Which substance facilitates the process of phagocytosis through opsonization?
Which immunoglobulin is known as the 'antiseptic paint' of mucous membranes?
Which immunoglobulin is known as the 'antiseptic paint' of mucous membranes?
Which bodily fluid does NOT contain Secretory IgA?
Which bodily fluid does NOT contain Secretory IgA?
Which form of IgA can activate the complement system in the presence of lysozyme?
Which form of IgA can activate the complement system in the presence of lysozyme?
What is a primary characteristic of Serum IgA concerning the complement system?
What is a primary characteristic of Serum IgA concerning the complement system?
Which immunoglobulin is found in very low levels in blood?
Which immunoglobulin is found in very low levels in blood?
Which function is NOT associated with Secretory IgA?
Which function is NOT associated with Secretory IgA?
Which of the following describes the complement system activation in relation to IgD and Serum IgA?
Which of the following describes the complement system activation in relation to IgD and Serum IgA?
What is most accurate about comparing Serum IgA and Secretory IgA?
What is most accurate about comparing Serum IgA and Secretory IgA?
Which type of immune cell is primarily involved in cell-mediated immunity?
Which type of immune cell is primarily involved in cell-mediated immunity?
What is the main function of cytotoxic T cells?
What is the main function of cytotoxic T cells?
Where do T cells mature?
Where do T cells mature?
Which cells are considered part of the adaptive immune system?
Which cells are considered part of the adaptive immune system?
What triggers the activation of effector T cells?
What triggers the activation of effector T cells?
Which type of cells do Natural Killer cells mainly target?
Which type of cells do Natural Killer cells mainly target?
What distinguishes T helper cells from cytotoxic T cells?
What distinguishes T helper cells from cytotoxic T cells?
In what type of immune response are T helper cells most active
In what type of immune response are T helper cells most active
Lymphoblasts differentiate into which main type of immune cells?
Lymphoblasts differentiate into which main type of immune cells?
What is the role of antigen recognition in T cell activation?
What is the role of antigen recognition in T cell activation?
What is a key characteristic of B cell responses?
What is a key characteristic of B cell responses?
Where do mature B cells originate from?
Where do mature B cells originate from?
What type of immune response is primarily associated with B cells?
What type of immune response is primarily associated with B cells?
What is the primary function of plasma cells?
What is the primary function of plasma cells?
What is a characteristic of the adaptive immune response?
What is a characteristic of the adaptive immune response?
Which of the following is NOT directly produced by B cells?
Which of the following is NOT directly produced by B cells?
What is the role of memory cells in adaptive immunity?
What is the role of memory cells in adaptive immunity?
What is the general function of mononuclear leukocytes?
What is the general function of mononuclear leukocytes?
Which of the following is a primary function of antibodies mentioned in the context?
Which of the following is a primary function of antibodies mentioned in the context?
What is the primary role of histamine release in the context of an immune response?
What is the primary role of histamine release in the context of an immune response?
Where do granulocytes primarily originate according to the context?
Where do granulocytes primarily originate according to the context?
What is a key characteristic of granulocytes related to their cellular content?
What is a key characteristic of granulocytes related to their cellular content?
According to the context, when do granulocytes mature and become fully functional?
According to the context, when do granulocytes mature and become fully functional?
What role do inflammatory mediators (cytokines) play according to the context?
What role do inflammatory mediators (cytokines) play according to the context?
What is the primary destination for granulocytes after they are recruited according to the context?
What is the primary destination for granulocytes after they are recruited according to the context?
What function is described as linked to the innate immune system in the provided text?
What function is described as linked to the innate immune system in the provided text?
Which type of leukocyte is derived from monocytes?
Which type of leukocyte is derived from monocytes?
What is the main effect of histamine being released as mentioned in the context?
What is the main effect of histamine being released as mentioned in the context?
Which of the following is NOT a reaction facilitated by inflammatory mediators as described in the text?
Which of the following is NOT a reaction facilitated by inflammatory mediators as described in the text?
Based on the text, what is the most potent type of innate immune response?
Based on the text, what is the most potent type of innate immune response?
What is the primary function of the antibodies mentioned in the text against hypersensitivity reactions?
What is the primary function of the antibodies mentioned in the text against hypersensitivity reactions?
Where does the final differentiation of granulocytes occur?
Where does the final differentiation of granulocytes occur?
Based on the context, what is the key effect of histamine release?
Based on the context, what is the key effect of histamine release?
Flashcards
Antigens
Antigens
Substances that trigger an immune response, including bacteria, fungi, algae, protozoa, viruses, parasites, chemicals, toxins, pollen, etc.
Lymphocytes
Lymphocytes
A type of white blood cell that plays a key role in the immune response by recognizing and destroying pathogens.
Cytokines
Cytokines
Small proteins produced by immune cells that act as messengers, coordinating the immune response and influencing other cells.
Type 1 and Type 2 Cytokines
Type 1 and Type 2 Cytokines
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Chemokines
Chemokines
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Colony Stimulating Factors (CSF)
Colony Stimulating Factors (CSF)
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Lymphokines
Lymphokines
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Monokines
Monokines
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Secretory IgA
Secretory IgA
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Serum IgA
Serum IgA
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IgD
IgD
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Complement System
Complement System
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Lysosome
Lysosome
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Complement Activation
Complement Activation
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B Cell Maturation
B Cell Maturation
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Plasma Cells
Plasma Cells
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Phagocytes
Phagocytes
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Neutrophils
Neutrophils
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Macrophages
Macrophages
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Dendritic cells
Dendritic cells
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Antibodies
Antibodies
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Complement proteins
Complement proteins
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Apoptosis
Apoptosis
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T lymphocyte
T lymphocyte
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T Helper cell
T Helper cell
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Cytotoxic T cell
Cytotoxic T cell
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CD8+ T cell
CD8+ T cell
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Th cell
Th cell
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Th1 cell
Th1 cell
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Th2 cell
Th2 cell
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Innate immune cell
Innate immune cell
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Adaptive immune cell
Adaptive immune cell
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Innate immune response
Innate immune response
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Granulocyte
Granulocyte
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Granulocyte (Granules)
Granulocyte (Granules)
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Histamine
Histamine
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Mononuclear leukocytes
Mononuclear leukocytes
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Innate Immunity
Innate Immunity
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Differentiation
Differentiation
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Recruitment
Recruitment
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Adaptive Immunity
Adaptive Immunity
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Inflammatory Mediators
Inflammatory Mediators
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Allergic reaction
Allergic reaction
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Allergen
Allergen
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Histamine (in allergic reaction)
Histamine (in allergic reaction)
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Study Notes
Immunology Terminology
-
Microbe: Microscopic organisms residing in water, soil, and air. Some microbes are pathogenic, others are important for health (commensal). Examples include bacteria, fungi, algae, protozoa, viruses, and parasites.
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Antigen: Any substance capable of triggering an immune response in the body. Antigens react specifically to generated antibodies and/or cells. Examples include bacteria, chemicals, toxins, viruses, pollen.
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Cytokine: A protein impacting the immune system by either enhancing or reducing its activity. It can occur naturally or be produced in labs for study. Examples are Interleukins, Lymphokines, Monokines, Interferons, colony stimulating factors, Chemokines and various other proteins. Specific types are produced by Th1 or Th2 T-helper cells.
Antibodies (Immunoglobulins)
- Antibody (Ig): Special proteins generated by white blood cells that fight or weaken pathogens. They travel through the bloodstream seeking pathogens.
- IgA: Found in respiratory tract linings, saliva, tears, breast milk (colostrum) - helps protect mucous membranes. Can activate the complement system when lysosomes are present (a type of cellular structure).
- IgD: Low levels in the blood; does not activate the complement system. Serves as part of the antigen-specific receptors on B lymphocytes.
- IgE: Present in small amounts in serum. Primarily associated with allergies (e.g., asthma, hay fever) and is attached to mast cells and basophils.
- IgG: The most abundant antibody in blood and tissue fluid (75%). Defends against diffusing toxins and invading microbes. Usually prominent in a secondary immune response and is transferrable through the placenta to give newborns passive protection.
- IgM: Largest immunoglobulin, typically the first antibody response in a primary immune response, but short-lived.
Phagocytes
- Phagocyte: Cells that engulf and destroy pathogens and cellular debris. Examples include monocytes, macrophages, granulocytes, and dendritic cells.
Proteins in the Immune System
- Proteins (in immune system): Large molecules (formed from amino acids) with specific functions regulated by nucleotides in the DNA. This can encompass a wide range of molecules: Antibodies, signalling proteins (cytokines), and complement proteins.
Opsonins
- Opsonins: Serum substances boosting phagocytosis of bacteria serving as markers (tags or identifiers).
- Opsonization: Coating an antigen with opsonins to attract phagocytic cells for consumption.
Antigen Presenting Cell (APC)
- Antigen Presenting Cell (APC): Cells processing protein antigens into peptides. They then present these peptides to T-cell receptors on their surfaces. Examples include macrophages, dendritic cells, and B cells.
Complement System
- Complement System: A group of proteins in the blood working in a cascade-like manner. It aids in host defence, inflammation, and phagocytosis of invading microbes. The system consists of various protein molecules, including a variety of other protein molecules, found in both the bloodstream and body tissues.
Cells of the Immune System
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PMNs (Polymorphonuclear Leukocytes): White blood cells (e.g., neutrophils, eosinophils, basophils, or mast cells) that play a major role in the body's innate immune system. They target foreign invaders, damaged cells, cellular debris, and inflammatory reactions.
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Macrophage: Large phagocytic cells derived from circulating monocytes. These cells play an integral role in phagocytosis (ingest foreign pathogens), antigen presentation, and inflammation response. They exist in many tissues, performing many functions, including: phagocytosis of dead or damaged cells and pathogens, presentation of antigens to T cells, and influencing the inflammatory response.
Cell-Mediated Immunity (Innate and Adaptive)
- Innate Immunity: This is a rapid non-specific response that does not require previous exposure to the pathogen. It involves various physical and chemical barriers, recognizing pathogens (non-specific) and triggering a rapid response (immediate).
- Adaptive Immunity: More a slower, specific reaction that requires prior exposure to the pathogen. It recognizes specific antigens and has memory, resulting in a stronger and faster response upon re-exposure.
Inflammation
- Inflammation: A complex response to tissue damage or infection involving recruitment of immune cells and mediators. Involves vascular fluid leakage, cellular signals, and tissue damage-inducing mediators. Signals and chemical mediators are released within the infected tissues, recruiting more immune cells.
Additional Notes
- Innate and Adaptive immunity are explained
- Mechanisms of oral cavity barriers and additional chemical mediators are detailed.
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