Immunology Moodle WB

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Questions and Answers

Which of the following is NOT considered a pathogen?

  • Pollen (correct)
  • Viruses
  • Bacteria
  • Parasites

Which category of substance includes interleukins and interferons?

  • Pathogens
  • Cytokines (correct)
  • Toxins
  • Antigens

Which of the following is best categorized as an antigen?

  • Colony stimulating factor (CSF)
  • Interferon
  • Lymphokine
  • Toxin (correct)

What type of cells primarily produces Type-1 cytokines?

<p>Th1 T-helper cells (C)</p> Signup and view all the answers

Which is NOT a category of immune-related molecules?

<p>Lipids (A)</p> Signup and view all the answers

Which of the following is an example of a chemical that can act as an antigen?

<p>Toxin (C)</p> Signup and view all the answers

What is the primary function of Colony Stimulating Factors (CSF)?

<p>Stimulate the production of immune cells (A)</p> Signup and view all the answers

Type-2 cytokines are produced by what type of cell?

<p>Th2 T-helper cells (A)</p> Signup and view all the answers

Which of the following cells are classified as phagocytes?

<p>Dendritic cells (A)</p> Signup and view all the answers

Which of these is a primary function of complement proteins?

<p>Enhance phagocytosis (D)</p> Signup and view all the answers

Which of the following is NOT a type of signalling protein mentioned in the content?

<p>Chemokines (B)</p> Signup and view all the answers

What process is synonymous with programmed cell death?

<p>Apoptosis (C)</p> Signup and view all the answers

Which of the following is an example of an antibody?

<p>IgG (B)</p> Signup and view all the answers

A phagocyte directly engulfing a bacterium is best described as what process?

<p>Phagocytosis (A)</p> Signup and view all the answers

Which type of immune cell is responsible for phagocytosing bacteria?

<p>Neutrophil (A)</p> Signup and view all the answers

Which substance facilitates the process of phagocytosis through opsonization?

<p>IgG antibody (D)</p> Signup and view all the answers

Which immunoglobulin is known as the 'antiseptic paint' of mucous membranes?

<p>Secretory IgA (C)</p> Signup and view all the answers

Which bodily fluid does NOT contain Secretory IgA?

<p>Blood (D)</p> Signup and view all the answers

Which form of IgA can activate the complement system in the presence of lysozyme?

<p>Secretory IgA (B)</p> Signup and view all the answers

What is a primary characteristic of Serum IgA concerning the complement system?

<p>It cannot activate the complement system. (B)</p> Signup and view all the answers

Which immunoglobulin is found in very low levels in blood?

<p>IgD (D)</p> Signup and view all the answers

Which function is NOT associated with Secretory IgA?

<p>Inhibiting complement system activation (B)</p> Signup and view all the answers

Which of the following describes the complement system activation in relation to IgD and Serum IgA?

<p>Neither IgD nor Serum IgA can activate the complement system. (A)</p> Signup and view all the answers

What is most accurate about comparing Serum IgA and Secretory IgA?

<p>Serum IgA cannot activate complement and secretory IgA can, with lysozyme. (C)</p> Signup and view all the answers

Which type of immune cell is primarily involved in cell-mediated immunity?

<p>Natural killer cells (C)</p> Signup and view all the answers

What is the main function of cytotoxic T cells?

<p>Destroying infected and tumour cells (D)</p> Signup and view all the answers

Where do T cells mature?

<p>Thymus (C)</p> Signup and view all the answers

Which cells are considered part of the adaptive immune system?

<p>T helper cells (D)</p> Signup and view all the answers

What triggers the activation of effector T cells?

<p>Recognition of a specific antigen on a dendritic cell (A)</p> Signup and view all the answers

Which type of cells do Natural Killer cells mainly target?

<p>Virus infected and tumour cells (B)</p> Signup and view all the answers

What distinguishes T helper cells from cytotoxic T cells?

<p>The surface protein markers they express. (D)</p> Signup and view all the answers

In what type of immune response are T helper cells most active

<p>Adaptive immunity (A)</p> Signup and view all the answers

Lymphoblasts differentiate into which main type of immune cells?

<p>T helper and cytotoxic T cells (A)</p> Signup and view all the answers

What is the role of antigen recognition in T cell activation?

<p>It is a prerequisite for triggering an immune response (A)</p> Signup and view all the answers

What is a key characteristic of B cell responses?

<p>They require T cells for the response to some antigens. (A)</p> Signup and view all the answers

Where do mature B cells originate from?

<p>Bone marrow (B)</p> Signup and view all the answers

What type of immune response is primarily associated with B cells?

<p>Humoral immunity (C)</p> Signup and view all the answers

What is the primary function of plasma cells?

<p>To produce antibodies (A)</p> Signup and view all the answers

What is a characteristic of the adaptive immune response?

<p>It has memory of previous encounters (A)</p> Signup and view all the answers

Which of the following is NOT directly produced by B cells?

<p>Cytokines (C)</p> Signup and view all the answers

What is the role of memory cells in adaptive immunity?

<p>To provide long-term protection against reinfection (B)</p> Signup and view all the answers

What is the general function of mononuclear leukocytes?

<p>To be involved in an immune response (D)</p> Signup and view all the answers

Which of the following is a primary function of antibodies mentioned in the context?

<p>To counteract hypersensitivity reactions in the blood (A)</p> Signup and view all the answers

What is the primary role of histamine release in the context of an immune response?

<p>To allow for increased movement of immune cells to an area of injury (B)</p> Signup and view all the answers

Where do granulocytes primarily originate according to the context?

<p>In the bone marrow (A)</p> Signup and view all the answers

What is a key characteristic of granulocytes related to their cellular content?

<p>They are rich in histamine and heparin (C)</p> Signup and view all the answers

According to the context, when do granulocytes mature and become fully functional?

<p>Once they are recruited into the tissue where final differentiation takes place (D)</p> Signup and view all the answers

What role do inflammatory mediators (cytokines) play according to the context?

<p>They are released by various antigens and are involved in a wide variety of reactions (A)</p> Signup and view all the answers

What is the primary destination for granulocytes after they are recruited according to the context?

<p>Tissues specific to their final differentiation site (D)</p> Signup and view all the answers

What function is described as linked to the innate immune system in the provided text?

<p>The capture and processing of antigens (B)</p> Signup and view all the answers

Which type of leukocyte is derived from monocytes?

<p>Mononuclear leukocyte (A)</p> Signup and view all the answers

What is the main effect of histamine being released as mentioned in the context?

<p>It causes an increase in blood vessel dilation to bring more immune cells to the area of injury. (A)</p> Signup and view all the answers

Which of the following is NOT a reaction facilitated by inflammatory mediators as described in the text?

<p>Response to blood vessel constriction (B)</p> Signup and view all the answers

Based on the text, what is the most potent type of innate immune response?

<p>Capture and processing of antigens (C)</p> Signup and view all the answers

What is the primary function of the antibodies mentioned in the text against hypersensitivity reactions?

<p>To modulate and limit the action of histamine (A)</p> Signup and view all the answers

Where does the final differentiation of granulocytes occur?

<p>Within specific tissues after being recruited from the bloodstream (D)</p> Signup and view all the answers

Based on the context, what is the key effect of histamine release?

<p>It leads to dilation of blood vessels that results in more immune cells moving to affected areas. (D)</p> Signup and view all the answers

Flashcards

Antigens

Substances that trigger an immune response, including bacteria, fungi, algae, protozoa, viruses, parasites, chemicals, toxins, pollen, etc.

Lymphocytes

A type of white blood cell that plays a key role in the immune response by recognizing and destroying pathogens.

Cytokines

Small proteins produced by immune cells that act as messengers, coordinating the immune response and influencing other cells.

Type 1 and Type 2 Cytokines

Cytokines produced by T helper (Th) cells. Type 1 cytokines are produced by Th1 cells, while Type 2 cytokines are produced by Th2 cells.

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Chemokines

A type of cytokine that acts as a signaling molecule, attracting other immune cells to the site of infection or inflammation.

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Colony Stimulating Factors (CSF)

A type of cytokine that stimulates the production of other cells in the immune system, like white blood cells.

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Lymphokines

Cytokines produced by T helper cells that help activate other immune cells like macrophages and cytotoxic T cells.

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Monokines

Cytokines produced by monocytes. These cytokines play a role in inflammation and immune response.

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Secretory IgA

A type of antibody found in bodily fluids like saliva, tears, and breast milk. It acts as a first line of defense against pathogens.

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Serum IgA

Found in the blood, this antibody does not activate the complement system.

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IgD

A type of antibody found in very low levels in the blood.

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Complement System

A complex system of proteins that helps the immune system fight infections.

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Lysosome

Chemicals that can damage and destroy cells.

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Complement Activation

A process where antibodies bind to pathogens and activate the complement system, ultimately leading to their destruction.

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B Cell Maturation

A complex process where B cells mature and become plasma cells, which are capable of producing antibodies.

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Plasma Cells

Specialized immune cells that produce antibodies in response to specific antigens.

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Phagocytes

A type of white blood cell that plays a key role in the immune system. They engulf and destroy pathogens through a process called phagocytosis.

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Neutrophils

A type of phagocyte that is the most common type of white blood cell in the blood. They are the first responders to infection and quickly kill bacteria.

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Macrophages

A type of phagocyte that is larger than neutrophils. They are found in tissues and are important for long-term immune responses.

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Dendritic cells

A type of phagocyte that presents antigens to T cells, which are another type of immune cell. This helps to activate the adaptive immune response.

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Antibodies

Proteins produced by the immune system that bind to specific antigens, which are molecules that trigger an immune response. They help to neutralize pathogens and mark them for destruction.

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Complement proteins

A group of proteins that circulate in the blood and help to destroy pathogens by forming a pore in their cell membrane. They are part of the innate immune system.

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Apoptosis

The process by which a cell is programmed to die. It is a normal and controlled part of development and immune function.

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T lymphocyte

A type of white blood cell that develops within the thymus gland, where it matures and becomes able to recognize and attack specific antigens.

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T Helper cell

A type of T lymphocyte that helps other immune cells to fight off infections by releasing cytokines.

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Cytotoxic T cell

A type of T cell that directly attacks virus-infected cells and cancer cells.

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CD8+ T cell

A type of T cell that targets and kills cells that have been infected by viruses or have become cancerous.

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Th cell

A type of T cell that helps to activate other immune cells, such as macrophages and B cells, and plays a crucial role in regulating the immune response.

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Th1 cell

A type of T cell that activates macrophages.

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Th2 cell

A type of T cell that is responsible for initiating the immune response by signaling for the creation of antibodies.

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Innate immune cell

A type of white blood cell that does not need to be exposed to an antigen in order to respond to it.

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Adaptive immune cell

A type of white blood cell that does need to be exposed to an antigen in order to respond to it.

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Innate immune response

A type of immune response that is non-specific and targets a wide range of pathogens.

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Granulocyte

A type of white blood cell derived from myeloid stem cells in the bone marrow.

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Granulocyte (Granules)

A type of granulocyte that releases histamine and heparin in the bloodstream.

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Histamine

A chemical released in the bloodstream in response to allergic reactions or infections that dilates blood vessels and increases blood flow to the affected area.

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Mononuclear leukocytes

A type of white blood cell that is a potent type of innate immunity cells and they are most effective against infections.

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Innate Immunity

The body's natural defense system that is always active and acts immediately to fight infections.

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Differentiation

The process by which a cell develops from an immature to a mature form.

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Recruitment

The process by which cells are recruited to a specific site in the body.

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Adaptive Immunity

A type of immune response that is specific to a particular type of pathogen or antigen.

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Inflammatory Mediators

A group of chemicals released as part of the innate immune response that help to initiate and amplify inflammation.

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Allergic reaction

The immune system's response to allergens, which can cause symptoms such as sneezing, runny nose, and itchy eyes.

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Allergen

A substance that causes an allergic reaction.

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Histamine (in allergic reaction)

A type of inflammatory mediator that causes blood vessels to dilate, increasing blood flow to the affected area.

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Study Notes

Immunology Terminology

  • Microbe: Microscopic organisms residing in water, soil, and air. Some microbes are pathogenic, others are important for health (commensal). Examples include bacteria, fungi, algae, protozoa, viruses, and parasites.

  • Antigen: Any substance capable of triggering an immune response in the body. Antigens react specifically to generated antibodies and/or cells. Examples include bacteria, chemicals, toxins, viruses, pollen.

  • Cytokine: A protein impacting the immune system by either enhancing or reducing its activity. It can occur naturally or be produced in labs for study. Examples are Interleukins, Lymphokines, Monokines, Interferons, colony stimulating factors, Chemokines and various other proteins. Specific types are produced by Th1 or Th2 T-helper cells.

Antibodies (Immunoglobulins)

  • Antibody (Ig): Special proteins generated by white blood cells that fight or weaken pathogens. They travel through the bloodstream seeking pathogens.
  • IgA: Found in respiratory tract linings, saliva, tears, breast milk (colostrum) - helps protect mucous membranes. Can activate the complement system when lysosomes are present (a type of cellular structure).
  • IgD: Low levels in the blood; does not activate the complement system. Serves as part of the antigen-specific receptors on B lymphocytes.
  • IgE: Present in small amounts in serum. Primarily associated with allergies (e.g., asthma, hay fever) and is attached to mast cells and basophils.
  • IgG: The most abundant antibody in blood and tissue fluid (75%). Defends against diffusing toxins and invading microbes. Usually prominent in a secondary immune response and is transferrable through the placenta to give newborns passive protection.
  • IgM: Largest immunoglobulin, typically the first antibody response in a primary immune response, but short-lived.

Phagocytes

  • Phagocyte: Cells that engulf and destroy pathogens and cellular debris. Examples include monocytes, macrophages, granulocytes, and dendritic cells.

Proteins in the Immune System

  • Proteins (in immune system): Large molecules (formed from amino acids) with specific functions regulated by nucleotides in the DNA. This can encompass a wide range of molecules: Antibodies, signalling proteins (cytokines), and complement proteins.

Opsonins

  • Opsonins: Serum substances boosting phagocytosis of bacteria serving as markers (tags or identifiers).
  • Opsonization: Coating an antigen with opsonins to attract phagocytic cells for consumption.

Antigen Presenting Cell (APC)

  • Antigen Presenting Cell (APC): Cells processing protein antigens into peptides. They then present these peptides to T-cell receptors on their surfaces. Examples include macrophages, dendritic cells, and B cells.

Complement System

  • Complement System: A group of proteins in the blood working in a cascade-like manner. It aids in host defence, inflammation, and phagocytosis of invading microbes. The system consists of various protein molecules, including a variety of other protein molecules, found in both the bloodstream and body tissues.

Cells of the Immune System

  • PMNs (Polymorphonuclear Leukocytes): White blood cells (e.g., neutrophils, eosinophils, basophils, or mast cells) that play a major role in the body's innate immune system. They target foreign invaders, damaged cells, cellular debris, and inflammatory reactions.

  • Macrophage: Large phagocytic cells derived from circulating monocytes. These cells play an integral role in phagocytosis (ingest foreign pathogens), antigen presentation, and inflammation response. They exist in many tissues, performing many functions, including: phagocytosis of dead or damaged cells and pathogens, presentation of antigens to T cells, and influencing the inflammatory response.

Cell-Mediated Immunity (Innate and Adaptive)

  • Innate Immunity: This is a rapid non-specific response that does not require previous exposure to the pathogen. It involves various physical and chemical barriers, recognizing pathogens (non-specific) and triggering a rapid response (immediate).
  • Adaptive Immunity: More a slower, specific reaction that requires prior exposure to the pathogen. It recognizes specific antigens and has memory, resulting in a stronger and faster response upon re-exposure.

Inflammation

  • Inflammation: A complex response to tissue damage or infection involving recruitment of immune cells and mediators. Involves vascular fluid leakage, cellular signals, and tissue damage-inducing mediators. Signals and chemical mediators are released within the infected tissues, recruiting more immune cells.

Additional Notes

  • Innate and Adaptive immunity are explained
  • Mechanisms of oral cavity barriers and additional chemical mediators are detailed.

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