Immunology Basics Quiz

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Questions and Answers

What is the primary purpose of a vaccine?

  • To produce specific protection against a disease (correct)
  • To promote allergic reactions for immune training
  • To cause an immediate disease response in the body
  • To directly eliminate pathogens from the body

Which statement correctly describes the duration of protection provided by vaccines?

  • Vaccination always provides lifelong immunity without any further doses
  • Vaccines provide uniform protection duration regardless of type
  • Passive immunization events always lead to longer protection
  • Vaccines generally offer shorter duration protection than naturally acquired immunity (correct)

What type of antibodies are transferred from mother to fetus during pregnancy?

  • Maternally acquired antibodies (correct)
  • Postnatal antibodies
  • Autoimmune antibodies
  • Artificially acquired antibodies

What are the two types of immunization mentioned in the content?

<p>Active and passive immunization (D)</p> Signup and view all the answers

What type of bacterial vaccine is produced using organisms killed by heat or chemicals?

<p>Killed (inactivated) vaccines (C)</p> Signup and view all the answers

What is the main difference between active and passive immunity?

<p>Active immunity takes time for processing antigens. (B)</p> Signup and view all the answers

Which option best describes passive immunity?

<p>It provides immediate protection without prior exposure. (D)</p> Signup and view all the answers

In the context of acquired immunity, which category involves antigen exposure?

<p>Active immunity (D)</p> Signup and view all the answers

Which aspect of active immunity is critical for its effectiveness?

<p>Delayed antigen processing (A)</p> Signup and view all the answers

Why is passive immunity described as having no active role?

<p>Antibodies are derived from another organism. (A), It does not involve any cellular response. (B)</p> Signup and view all the answers

What kind of immune response is generated by exposure to a pathogen in active immunity?

<p>Specific immune stimulation (A)</p> Signup and view all the answers

What role do immune cells play in active immunity?

<p>They process and respond to antigens. (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of passive immunity?

<p>Immune memory formation (B)</p> Signup and view all the answers

What type of vaccine uses weakened live bacteria?

<p>Live attenuated vaccine (D)</p> Signup and view all the answers

Which of the following vaccines is specifically an example of a toxoid vaccine?

<p>Tetanus toxoid vaccine (D)</p> Signup and view all the answers

Which vaccine type is known to be less temperature stable?

<p>Live attenuated vaccine (C)</p> Signup and view all the answers

What is the main concern with using live attenuated vaccines in immunocompromised patients?

<p>Reversion to a virulent form (A)</p> Signup and view all the answers

What does the 'cold chain' refer to in vaccine logistics?

<p>A storage and transport system for vaccines (A)</p> Signup and view all the answers

Which vaccine is an example of a killed (inactivated) vaccine?

<p>Salk polio vaccine (A)</p> Signup and view all the answers

What is a significant advantage of live vaccines over killed vaccines?

<p>Stronger immune response (B)</p> Signup and view all the answers

What type of vaccines does the hepatitis B vaccine use?

<p>Isolated viral antigen (A)</p> Signup and view all the answers

What is the primary purpose of administering hepatitis B immune globulin (HBIG)?

<p>To provide passive immunity for hepatitis B exposure (C)</p> Signup and view all the answers

Which of the following is a common adjuvant used to enhance immune response?

<p>Aluminum salts (C)</p> Signup and view all the answers

What is a primary function of adjuvants in vaccination?

<p>To enhance the immune response to specific antigens (C)</p> Signup and view all the answers

What potential side effect may occur from vaccination?

<p>Redness and tenderness at the injection site (D)</p> Signup and view all the answers

Which of the following correctly describes a hazard of immunization?

<p>No immune response is free from adverse reactions (D)</p> Signup and view all the answers

What is the role of cytokines as recent adjuvants in vaccines?

<p>To enhance secretion of other immune cells and recruitment of specific lymphocytes (A)</p> Signup and view all the answers

In the context of maternal health, what precaution is taken for a pregnant female infected with HBV?

<p>Use of hepatitis B immune globulin to protect the fetus (A)</p> Signup and view all the answers

What is the method of action of adjuvants in vaccines?

<p>Trapping antigen in tissues for prolonged exposure (D)</p> Signup and view all the answers

Flashcards

Acquired Immunity

A type of immunity that is acquired after exposure to an antigen, such as through vaccination or infection.

Active Immunity

A type of acquired immunity where the body's immune system actively produces antibodies or lymphocytes in response to an antigen.

Passive Immunity

A type of acquired immunity where antibodies or lymphocytes are transferred from one individual to another, providing immediate protection.

Antigen

Any substance that triggers an immune response. This generally means a foreign molecule, like a protein or carbohydrate, that is not normally found in the body.

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Immune System

The body's natural defense system that protects against disease. It recognizes and eliminates harmful substances or pathogens.

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Vaccination

The process of introducing a weakened or inactivated form of a pathogen into the body to stimulate an immune response and provide lasting protection against the disease.

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Immunization

The introduction of potentially harmful substances into the body, usually by injection or oral administration, to trigger an immune response.

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Antibodies

Antibodies are proteins produced by the immune system that recognize and bind to specific antigens, neutralizing them or marking them for destruction.

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Pre-existing Antibodies

Antibodies that are already present in the body and ready to immediately fight off pathogens.

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Natural Infection

The process of developing immunity through exposure to a pathogen, usually through infection.

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Active Immunization

The process of developing immunity through the introduction of a weakened or inactive form of a pathogen, usually through vaccination.

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Passive Immunization

The process of transferring pre-formed antibodies from one person to another, usually through injection.

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Vaccine

A substance that stimulates the immune system to produce antibodies against a specific pathogen.

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Live Attenuated Vaccine

A type of vaccine that uses a weakened version of the actual pathogen to trigger an immune response.

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Killed (Inactivated) Vaccine

A vaccine that contains a killed or inactivated version of the pathogen.

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Bacterial Material

A component of a bacteria, like a capsule, that can trigger an immune response.

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Toxoid

A toxin produced by a bacteria that has been treated with formaldehyde to make it safe but still able to stimulate an immune response.

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Viral Antigen Vaccine

A vaccine that uses a viral antigen, such as the surface protein of a virus, to trigger an immune response.

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Cold Chain

The process of maintaining a specific temperature range for storing and transporting vaccines to ensure their effectiveness.

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Cold Chain System

A system that involves the storage and transport of vaccines at appropriate temperatures from their origin to the vaccination site.

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Temperature Sensitive Vaccines

Vaccines that are less stable at higher temperatures and may lose their effectiveness if exposed to heat.

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Hepatitis B Immune Globulin (HBIG)

Hepatitis B Immune Globulin (HBIG) is a specific type of passive immunization, containing ready-made antibodies against hepatitis B virus, used to prevent infection.

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What are Adjuvants?

Adjuvants are substances added to vaccines to enhance the immune response to the antigen, improving vaccine efficacy.

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Aluminum Salts as Adjuvants

Aluminum salts are commonly used as adjuvants in vaccines. They enhance the immune response by trapping antigens in tissues, increasing exposure to immune cells.

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Cytokines as Adjuvants

Cytokines, like IL-2, IL-12, and interferon-gamma, are newer adjuvants that enhance immune response by stimulating immune cell production and activity.

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What is the role of Adjuvants in immune response?

Adjuvants are not directly involved in fighting infection. They enhance the immune response to the antigen introduced in the vaccine.

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What are some hazards of immunization?

Vaccination can have some side effects, like redness, tenderness, or swelling at the injection site.

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Are there any risks associated with the immune response?

All immune responses carry a risk of adverse reactions, although they are usually mild and temporary.

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Study Notes

Vaccination Lectures

  • Vaccination is an important part of acquired immunity
  • Vaccination classification is based on clinical application
  • Active immunity: Introduces an antigen to the immune system
    • Microorganisms interact with immune cells
    • Results in specific immune stimulation
  • Passive immunity: Transfer of ready antibodies or lymphocytes to an individual
    • No active role of the immune system
    • Immediate onset of protection
    • Shorter duration of protection
    • No memory cell development
    • Examples: maternally acquired antibodies, passive immunization
  • Vaccination occurs by introducing microorganisms or their products in a harmless state into a host
  • Types of Vaccines:
    • Killed (inactivated): Using organisms killed by heat or chemicals (e.g., typhoid vaccine)
    • Live attenuated: Weakened form of the organism (e.g., BCG for tuberculosis)
    • Bacterial materials:
      • Structure components: Like capsules of bacteria (e.g., meningococcal vaccine)
      • Toxoids: Treated toxins of bacteria (e.g., tetanus toxoid)
    • Viral components:
      • Intact virus: Killed or live attenuated (e.g., Salk and Sabin polio vaccines.)
      • Isolated viral antigens: Composed of viral surface antigens (e.g., hepatitis B vaccine)

Live vs Killed Vaccines

  • Killed vaccines cannot enter the MHC I pathway and cannot induce cytotoxic T cells
  • Live vaccines can access both MHC I and II pathways, inducing both cytotoxic and helper T cells, resulting in a better immune response
  • Live vaccines have some drawbacks including temperature stability issues and potential reversion to more virulent forms
  • Live vaccines should not be given to pregnant women or immunocompromised patients

Cold Chain

  • The cold chain is a system for storing and transporting vaccines at low temperatures from the source to the vaccination site
  • Crucial for maintaining vaccine efficacy due to potential failure from ineffective storage and transport

Passive Immunization

  • Hepatitis B immune globulin (HBIG): Used to prevent Hepatitis B in individuals exposed to the virus (needle-stick, mother-child transmission)
    • High antibody titer to hepatitis B virus
    • Derived from humans to avoid hypersensitivity reactions
  • Varicella-zoster immune globulin (VZIG): Contains high titer antibodies to varicella zoster virus
    • Derived from humans to prevent hypersensitivity reactions

Adjuvants

  • Substances added to vaccines to enhance the immune response to the antigen
  • Can trap antigen in tissues, increasing exposure to antigen-presenting cells and lymphocytes
  • Used frequently include aluminum salts, cytokines like IL-2, IL-12, and interferon-gamma

Hazards of Immunization

  • No immune response is entirely free from risk of adverse reactions
  • Potential reactions include
    • Localized reactions at the inoculation site
    • Reactions from faulty techniques
    • Hypersensitivity reactions
    • Neurological involvement

References

  • Review of Medical Microbiology and Immunology, 13th edition, chapter 36
  • Jawetz, Melnick, and Adelberg's 26th edition of Medical Microbiology, chapter 8

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