Podcast
Questions and Answers
What is the primary purpose of a vaccine?
What is the primary purpose of a vaccine?
- To produce specific protection against a disease (correct)
- To promote allergic reactions for immune training
- To cause an immediate disease response in the body
- To directly eliminate pathogens from the body
Which statement correctly describes the duration of protection provided by vaccines?
Which statement correctly describes the duration of protection provided by vaccines?
- Vaccination always provides lifelong immunity without any further doses
- Vaccines provide uniform protection duration regardless of type
- Passive immunization events always lead to longer protection
- Vaccines generally offer shorter duration protection than naturally acquired immunity (correct)
What type of antibodies are transferred from mother to fetus during pregnancy?
What type of antibodies are transferred from mother to fetus during pregnancy?
- Maternally acquired antibodies (correct)
- Postnatal antibodies
- Autoimmune antibodies
- Artificially acquired antibodies
What are the two types of immunization mentioned in the content?
What are the two types of immunization mentioned in the content?
What type of bacterial vaccine is produced using organisms killed by heat or chemicals?
What type of bacterial vaccine is produced using organisms killed by heat or chemicals?
What is the main difference between active and passive immunity?
What is the main difference between active and passive immunity?
Which option best describes passive immunity?
Which option best describes passive immunity?
In the context of acquired immunity, which category involves antigen exposure?
In the context of acquired immunity, which category involves antigen exposure?
Which aspect of active immunity is critical for its effectiveness?
Which aspect of active immunity is critical for its effectiveness?
Why is passive immunity described as having no active role?
Why is passive immunity described as having no active role?
What kind of immune response is generated by exposure to a pathogen in active immunity?
What kind of immune response is generated by exposure to a pathogen in active immunity?
What role do immune cells play in active immunity?
What role do immune cells play in active immunity?
Which of the following is NOT a characteristic of passive immunity?
Which of the following is NOT a characteristic of passive immunity?
What type of vaccine uses weakened live bacteria?
What type of vaccine uses weakened live bacteria?
Which of the following vaccines is specifically an example of a toxoid vaccine?
Which of the following vaccines is specifically an example of a toxoid vaccine?
Which vaccine type is known to be less temperature stable?
Which vaccine type is known to be less temperature stable?
What is the main concern with using live attenuated vaccines in immunocompromised patients?
What is the main concern with using live attenuated vaccines in immunocompromised patients?
What does the 'cold chain' refer to in vaccine logistics?
What does the 'cold chain' refer to in vaccine logistics?
Which vaccine is an example of a killed (inactivated) vaccine?
Which vaccine is an example of a killed (inactivated) vaccine?
What is a significant advantage of live vaccines over killed vaccines?
What is a significant advantage of live vaccines over killed vaccines?
What type of vaccines does the hepatitis B vaccine use?
What type of vaccines does the hepatitis B vaccine use?
What is the primary purpose of administering hepatitis B immune globulin (HBIG)?
What is the primary purpose of administering hepatitis B immune globulin (HBIG)?
Which of the following is a common adjuvant used to enhance immune response?
Which of the following is a common adjuvant used to enhance immune response?
What is a primary function of adjuvants in vaccination?
What is a primary function of adjuvants in vaccination?
What potential side effect may occur from vaccination?
What potential side effect may occur from vaccination?
Which of the following correctly describes a hazard of immunization?
Which of the following correctly describes a hazard of immunization?
What is the role of cytokines as recent adjuvants in vaccines?
What is the role of cytokines as recent adjuvants in vaccines?
In the context of maternal health, what precaution is taken for a pregnant female infected with HBV?
In the context of maternal health, what precaution is taken for a pregnant female infected with HBV?
What is the method of action of adjuvants in vaccines?
What is the method of action of adjuvants in vaccines?
Flashcards
Acquired Immunity
Acquired Immunity
A type of immunity that is acquired after exposure to an antigen, such as through vaccination or infection.
Active Immunity
Active Immunity
A type of acquired immunity where the body's immune system actively produces antibodies or lymphocytes in response to an antigen.
Passive Immunity
Passive Immunity
A type of acquired immunity where antibodies or lymphocytes are transferred from one individual to another, providing immediate protection.
Antigen
Antigen
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Immune System
Immune System
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Vaccination
Vaccination
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Immunization
Immunization
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Antibodies
Antibodies
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Pre-existing Antibodies
Pre-existing Antibodies
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Natural Infection
Natural Infection
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Active Immunization
Active Immunization
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Passive Immunization
Passive Immunization
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Vaccine
Vaccine
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Live Attenuated Vaccine
Live Attenuated Vaccine
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Killed (Inactivated) Vaccine
Killed (Inactivated) Vaccine
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Bacterial Material
Bacterial Material
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Toxoid
Toxoid
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Viral Antigen Vaccine
Viral Antigen Vaccine
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Cold Chain
Cold Chain
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Cold Chain System
Cold Chain System
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Temperature Sensitive Vaccines
Temperature Sensitive Vaccines
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Hepatitis B Immune Globulin (HBIG)
Hepatitis B Immune Globulin (HBIG)
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What are Adjuvants?
What are Adjuvants?
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Aluminum Salts as Adjuvants
Aluminum Salts as Adjuvants
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Cytokines as Adjuvants
Cytokines as Adjuvants
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What is the role of Adjuvants in immune response?
What is the role of Adjuvants in immune response?
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What are some hazards of immunization?
What are some hazards of immunization?
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Are there any risks associated with the immune response?
Are there any risks associated with the immune response?
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Study Notes
Vaccination Lectures
- Vaccination is an important part of acquired immunity
- Vaccination classification is based on clinical application
- Active immunity: Introduces an antigen to the immune system
- Microorganisms interact with immune cells
- Results in specific immune stimulation
- Passive immunity: Transfer of ready antibodies or lymphocytes to an individual
- No active role of the immune system
- Immediate onset of protection
- Shorter duration of protection
- No memory cell development
- Examples: maternally acquired antibodies, passive immunization
- Vaccination occurs by introducing microorganisms or their products in a harmless state into a host
- Types of Vaccines:
- Killed (inactivated): Using organisms killed by heat or chemicals (e.g., typhoid vaccine)
- Live attenuated: Weakened form of the organism (e.g., BCG for tuberculosis)
- Bacterial materials:
- Structure components: Like capsules of bacteria (e.g., meningococcal vaccine)
- Toxoids: Treated toxins of bacteria (e.g., tetanus toxoid)
- Viral components:
- Intact virus: Killed or live attenuated (e.g., Salk and Sabin polio vaccines.)
- Isolated viral antigens: Composed of viral surface antigens (e.g., hepatitis B vaccine)
Live vs Killed Vaccines
- Killed vaccines cannot enter the MHC I pathway and cannot induce cytotoxic T cells
- Live vaccines can access both MHC I and II pathways, inducing both cytotoxic and helper T cells, resulting in a better immune response
- Live vaccines have some drawbacks including temperature stability issues and potential reversion to more virulent forms
- Live vaccines should not be given to pregnant women or immunocompromised patients
Cold Chain
- The cold chain is a system for storing and transporting vaccines at low temperatures from the source to the vaccination site
- Crucial for maintaining vaccine efficacy due to potential failure from ineffective storage and transport
Passive Immunization
- Hepatitis B immune globulin (HBIG): Used to prevent Hepatitis B in individuals exposed to the virus (needle-stick, mother-child transmission)
- High antibody titer to hepatitis B virus
- Derived from humans to avoid hypersensitivity reactions
- Varicella-zoster immune globulin (VZIG): Contains high titer antibodies to varicella zoster virus
- Derived from humans to prevent hypersensitivity reactions
Adjuvants
- Substances added to vaccines to enhance the immune response to the antigen
- Can trap antigen in tissues, increasing exposure to antigen-presenting cells and lymphocytes
- Used frequently include aluminum salts, cytokines like IL-2, IL-12, and interferon-gamma
Hazards of Immunization
- No immune response is entirely free from risk of adverse reactions
- Potential reactions include
- Localized reactions at the inoculation site
- Reactions from faulty techniques
- Hypersensitivity reactions
- Neurological involvement
References
- Review of Medical Microbiology and Immunology, 13th edition, chapter 36
- Jawetz, Melnick, and Adelberg's 26th edition of Medical Microbiology, chapter 8
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