Immune System Overview Quiz
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Questions and Answers

What is the primary role of B cells in the immune response?

  • Secrete antibodies that identify pathogens. (correct)
  • Coordinate the immune response.
  • Directly destroy infected cells.
  • Capture fragments of antigens.
  • Which type of cells act as messengers in the immune system?

  • Dendritic cells (correct)
  • Cytotoxic T cells
  • B cells
  • Helper T cells
  • What initiates the activation of the third line of defense?

  • Blood vessels dilating.
  • Dendritic cells taking antigens to lymphocytes. (correct)
  • The presence of macrophages in tissues.
  • The secretion of antibodies by B cells.
  • During an inflammatory response, which cells are primarily responsible for detecting invaders?

    <p>Macrophages (C)</p> Signup and view all the answers

    What is the function of cytotoxic T cells in the immune system?

    <p>Kill infected cells directly. (B)</p> Signup and view all the answers

    How do dendritic cells assist in the immune response?

    <p>By providing precise information about pathogens to helper T cells. (B)</p> Signup and view all the answers

    What occurs when there is a barrier breakdown in the immune defense process?

    <p>Injury or infection allows pathogens to enter. (C)</p> Signup and view all the answers

    What is the first line of defense against pathogens?

    <p>Skin and mucous membranes. (A)</p> Signup and view all the answers

    What is the primary function of macrophages in the immune system?

    <p>To eliminate dead cells and stimulate healing (B)</p> Signup and view all the answers

    How does the immune system develop memory for future infections?

    <p>By creating immune memory (D)</p> Signup and view all the answers

    What marks the difference between disease pathogens and cancer in terms of evolutionary impact?

    <p>Pathogens influence natural selection more directly (C)</p> Signup and view all the answers

    Which of the following best describes the role of natural killer (NK) cells?

    <p>They kill cells infected by viruses (B)</p> Signup and view all the answers

    What is NOT a characteristic of the first line of defence in the immune system?

    <p>It involves white blood cell activity (A)</p> Signup and view all the answers

    What occurs during the second line of defence when pathogens enter the body?

    <p>Inflammation focuses on the infected area (C)</p> Signup and view all the answers

    Which type of white blood cells release toxic substances to deal with larger pathogens?

    <p>Granulocytes (C)</p> Signup and view all the answers

    What important function does the immune system perform in addition to fighting infections?

    <p>Eliminating dead cells and maintaining tissue homeostasis (C)</p> Signup and view all the answers

    What type of immunity involves T cells and B cells?

    <p>Adaptive immunity (A)</p> Signup and view all the answers

    What is the primary function of natural killer cells in the immune response?

    <p>To kill infected cells directly (D)</p> Signup and view all the answers

    What typically characterizes the primary immune response to an antigen?

    <p>A lag phase before antibodies are produced (C)</p> Signup and view all the answers

    Which of the following statements about the secondary immune response is true?

    <p>It shows a rapid response due to previous exposure. (A)</p> Signup and view all the answers

    What role do macrophages and dendritic cells play in the immune system?

    <p>They help activate T cells. (D)</p> Signup and view all the answers

    What is an antigen?

    <p>A substance that activates the immune system. (D)</p> Signup and view all the answers

    What characterizes innate immunity compared to adaptive immunity?

    <p>It reacts more quickly but is less specific. (A)</p> Signup and view all the answers

    What role do cytokines play in the immune response?

    <p>Cytokines increase in concentration in response to both primary and secondary exposures. (D)</p> Signup and view all the answers

    What specifically happens during the secondary response to a previously encountered antigen?

    <p>There is a rapid increase in antibody production. (D)</p> Signup and view all the answers

    What distinguishes the adaptive immune response from the innate immune response?

    <p>The adaptive immune response involves specific antibodies and T cells. (C)</p> Signup and view all the answers

    Which of the following describes the primary adaptive immune response?

    <p>The response develops over 7-14 days and activates antibodies and T cells. (A)</p> Signup and view all the answers

    How does immunological memory contribute to the immune response?

    <p>It allows for rapid and intense responses to reinfections, often preventing symptoms. (B)</p> Signup and view all the answers

    What is the time frame for the protective immunity phase of the adaptive immune response?

    <p>14-35 days after initial exposure. (B)</p> Signup and view all the answers

    Which cells are primarily involved in eliminating infected cells during the adaptive immune response?

    <p>Cytotoxic T lymphocytes (CTLs). (C)</p> Signup and view all the answers

    What distinguishes phagocytosis from endocytosis?

    <p>Phagocytosis is specialized for defense and involves large solid particles. (B)</p> Signup and view all the answers

    Which statement about the role of NK cells in the immune response is correct?

    <p>NK cells kill infected cells in response to cellular stress signals. (A)</p> Signup and view all the answers

    What is the significance of cytokine production in response to viral infection?

    <p>Cytokines limit viral replication and activate other immune mechanisms. (A)</p> Signup and view all the answers

    What is the primary function of neutrophils in the immune response?

    <p>Rapidly crossing blood vessels to infected areas. (D)</p> Signup and view all the answers

    Which cell type is primarily involved in the communication between innate and adaptive immunity?

    <p>Dendritic cells (C)</p> Signup and view all the answers

    How do eosinophils contribute to the immune response against multicellular parasites?

    <p>By releasing cytotoxic enzymes to damage them. (B)</p> Signup and view all the answers

    Which type of immune cell is primarily responsible for releasing histamine during allergic reactions?

    <p>Basophils (D)</p> Signup and view all the answers

    What happens to neutrophils after they have responded to an infection?

    <p>They die quickly and must be replenished. (A)</p> Signup and view all the answers

    What role do macrophages play in the immune system?

    <p>Capturing and breaking down microorganisms. (B)</p> Signup and view all the answers

    What is the primary role of memory lymphocytes in the immune system?

    <p>To facilitate a rapid response upon re-exposure to the same pathogen (C)</p> Signup and view all the answers

    Which statement best describes the function of basophils?

    <p>They mediate inflammation and allergic reactions. (D)</p> Signup and view all the answers

    What significant discovery did Edward Jenner make related to vaccination?

    <p>Inoculation with cowpox could protect against smallpox (A)</p> Signup and view all the answers

    Louis Pasteur's contributions to immunology include the development of which type of vaccination?

    <p>Both B and C (C)</p> Signup and view all the answers

    What distinguishes active vaccination from passive vaccination?

    <p>Active vaccination stimulates the immune system to produce its own memory cells (D)</p> Signup and view all the answers

    Which of the following statements is true regarding passive vaccination?

    <p>It provides short-term protection without creating immune memory (B)</p> Signup and view all the answers

    Emil von Behring is best known for his work in which area of immunology?

    <p>Developing the serotherapy technique using specific antibodies (D)</p> Signup and view all the answers

    What type of immunity does active vaccination aim to provide?

    <p>Long-lasting immunity through the production of memory cells (D)</p> Signup and view all the answers

    Which technique involves using antibodies extracted from an immunized individual to combat disease?

    <p>Passive vaccination (A)</p> Signup and view all the answers

    Flashcards

    Skin and mucous membranes

    They are part of the immune system's first line of defense, acting as a physical barrier to prevent pathogens from entering the body.

    Macrophages

    These cells patrol tissues and engulf pathogens, acting like tiny vacuum cleaners.

    Inflammation

    This is the body's immediate response to injury or infection, characterized by redness, swelling, heat, and pain.

    Lymphocytes

    They are specialized white blood cells that recognize and target specific pathogens, forming the body's third line of defense.

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    B cells

    These lymphocytes produce antibodies, which bind to pathogens and neutralize them.

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    Cytotoxic T cells

    These lymphocytes directly kill cells infected with viruses.

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    Dendritic cells

    These cells act as messengers that alert the immune system about the presence of pathogens.

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    Helper T cells

    These cells coordinate the immune response, activating other immune cells to fight the infection.

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    Self-tolerance

    The ability of the immune system to recognize and destroy pathogens without harming the body's own tissues.

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    First line of defense

    The body's first line of defense against pathogens, consisting of physical barriers like skin, tears, and eyelashes.

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    Phagocytic cells

    White blood cells specialized in engulfing and destroying pathogens, often acting as part of the body's second line of defense.

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    Natural Killer (NK) cells

    A key component of the immune system, working by recognizing and eliminating cells infected with viruses.

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    Immune memory

    A crucial function of the immune system that involves remembering past encounters with pathogens, allowing for faster and more efficient responses upon subsequent exposures.

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    Immunity

    The body's ability to resist future illnesses after experiencing a specific disease, due to the immune system's memory.

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    Pathogens

    Microscopic organisms that cause disease, including bacteria, viruses, and fungi.

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    What is phagocytosis?

    A type of endocytosis used by cells to engulf large solid particles, like bacteria or debris, into the cell.

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    Neutrophils

    White blood cells that quickly migrate to sites of infection and engulf pathogens.

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    Granulocytes

    A white blood cell that releases toxins outside the cell to kill pathogens.

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    Eosinophils

    A type of granulocyte that targets multicellular parasites.

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    Basophils

    A type of granulocyte involved in inflammation and allergic reactions.

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    Mast Cells

    Immune cells that reside in tissues and release inflammatory mediators.

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    Edward Jenner

    A physician who was a pioneer in the development of vaccines. He discovered that cowpox infection provided protection against smallpox, a much more serious disease.

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    Louis Pasteur

    A microbiologist who made key contributions to understanding disease causation and vaccine development. He developed the first vaccine against rabies.

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    Serotherapy

    Refers to the use of specific antibodies from a previously immunized individual or animal. This provides short-term protection against a pathogen.

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    Active vaccination

    A type of vaccination that involves introducing a weakened or killed pathogen or toxin into the body, stimulating the immune system to develop its own antibodies and memory cells.

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    Passive vaccination

    A type of vaccination that introduces ready-made antibodies from another source, providing immediate but short-lived protection.

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    Active vaccination using attenuated pathogens

    Involves using weakened pathogens or parts of pathogens to stimulate the immune system. This results in long-lasting immunity.

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    Active vaccination using dead pathogens

    Using dead bacteria or viruses to trigger an immune response without causing disease.

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    Natural Killer Cells

    A type of lymphocyte that directly kills infected cells without needing another cell to 'direct' it.

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    Innate Immunity

    A component of the immune system that provides a rapid, but non-specific response to infection. It includes neutrophils, macrophages, and NK cells.

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    Adaptive Immunity

    A specialized immune response that is activated by innate immunity and characterized by a slower but more targeted response to specific pathogens.

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    Antigen

    A substance that activates the immune system. It can be a protein, carbohydrate, or even a small molecule.

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    Primary Immune Response

    The initial exposure to an antigen, characterized by a slow and weaker response, as the immune system takes time to mount an adequate response.

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    Secondary Immune Response

    The rapid and strong immune response following a second exposure to the same antigen, due to 'immune memory' from the primary exposure.

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    Physical Barriers

    The body's first line of defense against pathogens, acting as a physical barrier to prevent them from entering the body.

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    Immunological Memory

    The ability of the adaptive immune system to remember pathogens it has encountered before, allowing for a faster and stronger response on subsequent encounters.

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    Cytokines

    Small signaling molecules released by cells to communicate with each other and coordinate the immune response. They act like messengers directing the immune system.

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    Virus Titer

    A measure of the concentration of a virus in the blood, representing its ability to infect.

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    Study Notes

    Introduction

    • Thucydides recognized people who recovered from a disease were immune.
    • The immune system protects against microscopic pathogens (like bacteria, fungi, and viruses).
    • Cancer and pathogens affect evolution differently.
    • Pathogens directly impact natural selection by favouring resistant individuals; cancers usually develop later after reproductive stage and don't hinder gene transmission.
    • The immune system also plays a role in tissue repair and regeneration.

    Defence Lines Immune System

    • First line of defence includes skin and openings (eyes, ears, etc.) that act as barriers.
    • Many pathogens can enter the body through openings.
    • Second line of defence: white blood cells (leukocytes) act in areas of pathogen entry.
    • Inflammation focuses on infection sites.
    • Specific types of white blood cells are involved.
      • NK cells kill virus-infected cells.
      • Phagocytic cells engulf and destroy pathogens.
      • Granulocytes release toxic substances to kill large pathogens (difficult to swallow).

    Third Line of Defence

    • Specialized white blood cells (lymphocytes) recognize and target pathogens.
    • Lymphocytes develop a memory to recognize future similar pathogens.
    • The "soldiers" B cells produce antibodies that identify pathogens, and cytotoxic T cells kill infected cells specifically.
    • Commanders like dendritic cells capture pathogen fragments and present them to the other immune system cells to coordinate the response.
    • Helper T cells coordinate the overall immune response.

    Immune Defence Process

    • First Line intact: Skin and mucous membranes prevent pathogen entry.
    • Barrier Breakdown: Injury or infection allows pathogens to enter. Macrophages and dendritic cells detect invaders triggering inflammation.
    • Arrival of additional white blood cells: Blood vessels dilate to allow white blood cells to reach the affected area.
    • Activation of third line: Dendritic cells present antigens to lymphocytes for activation. B cells produce antibody and T cells destroy infected cells.
    • Immune Memory: Memory lymphocytes rapidly respond to reinfection by the same pathogen.

    Great Figures in Immunology

    • Edward Jenner developed the first vaccine by recognizing cowpox protection from smallpox.
    • Louis Pasteur discovered that diseases are caused by microorganisms, developed vaccines for rabies, anthrax, and cholera, and used attenuated pathogens.
    • Emil von Behring demonstrated the effectiveness of serotherapy (using pre-made antibodies).

    Active vs Passive Vaccination

    • Active vaccination introduces antigens to stimulate the immune response, producing antibodies and memory cells for future protection.
    • Passive vaccination provides pre-made antibodies for immediate, short-term protection, without stimulating the recipient's immune system.

    Targets of the Immune System

    • Intracellular infections: The immune system faces significant challenges targeting pathogens within infected cells, requiring cell-mediated responses.
    • Extracellular infections: The immune system can target pathogens outside cells more readily.

    Cells of the Immune System

    • Phagocytes (Macrophages, neutrophils): Engulf and destroy pathogens through phagocytosis.
    • Dendritic cells: Initiate the adaptive immune response by presenting antigens to T lymphocytes.
    • Granulocytes (eosinophils, basophils, mast cells): Release toxic substances to kill pathogens, particularly parasites and involved in inflammatory and allergic responses.
    • T lymphocytes (various types): Initiate and regulate immune responses and eliminate infected cells. B lymphocytes and NK cells.

    Summary of Cells

    • Summary of cells: Leukocytes include phagocytes (macrophages, neutrophils, dendritic cells, monocytes), granulocytes (basophils, eosinophils, mast cells), and lymphocytes (T cells, B cells, NK cells).

    Lymphocytes

    • T cells: Recognize specific antigens, and include subtypes like CD8 (cytotoxic), helping T cells and regulatory cells.
    • B cells: Produce antibodies which attack pathogens.
    • Natural Killer (NK) cells: Kill infected cells without prior sensitization.

    Immune System Divisions

    • The immune system is divided into innate and adaptive immunity.
    • Innate: First line of defence, includes physical barriers, phagocytes, and complement proteins.
    • Adaptive: Develops a specific response to a particular pathogen; includes B and T cells and has "immune memory".

    Cytokine Concentration & Immune Responses

    • Cytokines play a key role in immune responses, supporting both primary and secondary responses.
    • Cytokines increase in secondary responses compared to primary ones due to recognition capability.
    • Innate response is relatively faster but less specific. Adaptive response has memory for future attacks.

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    Description

    Test your knowledge on the immune system and its defense mechanisms. This quiz covers the different lines of defense, the role of various white blood cells, and how immunity works against pathogens. Perfect for students learning about biology and human health.

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