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Questions and Answers
What is the primary role of B cells in the immune response?
What is the primary role of B cells in the immune response?
Which type of cells act as messengers in the immune system?
Which type of cells act as messengers in the immune system?
What initiates the activation of the third line of defense?
What initiates the activation of the third line of defense?
During an inflammatory response, which cells are primarily responsible for detecting invaders?
During an inflammatory response, which cells are primarily responsible for detecting invaders?
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What is the function of cytotoxic T cells in the immune system?
What is the function of cytotoxic T cells in the immune system?
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How do dendritic cells assist in the immune response?
How do dendritic cells assist in the immune response?
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What occurs when there is a barrier breakdown in the immune defense process?
What occurs when there is a barrier breakdown in the immune defense process?
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What is the first line of defense against pathogens?
What is the first line of defense against pathogens?
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What is the primary function of macrophages in the immune system?
What is the primary function of macrophages in the immune system?
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How does the immune system develop memory for future infections?
How does the immune system develop memory for future infections?
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What marks the difference between disease pathogens and cancer in terms of evolutionary impact?
What marks the difference between disease pathogens and cancer in terms of evolutionary impact?
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Which of the following best describes the role of natural killer (NK) cells?
Which of the following best describes the role of natural killer (NK) cells?
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What is NOT a characteristic of the first line of defence in the immune system?
What is NOT a characteristic of the first line of defence in the immune system?
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What occurs during the second line of defence when pathogens enter the body?
What occurs during the second line of defence when pathogens enter the body?
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Which type of white blood cells release toxic substances to deal with larger pathogens?
Which type of white blood cells release toxic substances to deal with larger pathogens?
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What important function does the immune system perform in addition to fighting infections?
What important function does the immune system perform in addition to fighting infections?
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What type of immunity involves T cells and B cells?
What type of immunity involves T cells and B cells?
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What is the primary function of natural killer cells in the immune response?
What is the primary function of natural killer cells in the immune response?
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What typically characterizes the primary immune response to an antigen?
What typically characterizes the primary immune response to an antigen?
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Which of the following statements about the secondary immune response is true?
Which of the following statements about the secondary immune response is true?
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What role do macrophages and dendritic cells play in the immune system?
What role do macrophages and dendritic cells play in the immune system?
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What is an antigen?
What is an antigen?
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What characterizes innate immunity compared to adaptive immunity?
What characterizes innate immunity compared to adaptive immunity?
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What role do cytokines play in the immune response?
What role do cytokines play in the immune response?
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What specifically happens during the secondary response to a previously encountered antigen?
What specifically happens during the secondary response to a previously encountered antigen?
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What distinguishes the adaptive immune response from the innate immune response?
What distinguishes the adaptive immune response from the innate immune response?
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Which of the following describes the primary adaptive immune response?
Which of the following describes the primary adaptive immune response?
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How does immunological memory contribute to the immune response?
How does immunological memory contribute to the immune response?
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What is the time frame for the protective immunity phase of the adaptive immune response?
What is the time frame for the protective immunity phase of the adaptive immune response?
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Which cells are primarily involved in eliminating infected cells during the adaptive immune response?
Which cells are primarily involved in eliminating infected cells during the adaptive immune response?
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What distinguishes phagocytosis from endocytosis?
What distinguishes phagocytosis from endocytosis?
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Which statement about the role of NK cells in the immune response is correct?
Which statement about the role of NK cells in the immune response is correct?
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What is the significance of cytokine production in response to viral infection?
What is the significance of cytokine production in response to viral infection?
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What is the primary function of neutrophils in the immune response?
What is the primary function of neutrophils in the immune response?
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Which cell type is primarily involved in the communication between innate and adaptive immunity?
Which cell type is primarily involved in the communication between innate and adaptive immunity?
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How do eosinophils contribute to the immune response against multicellular parasites?
How do eosinophils contribute to the immune response against multicellular parasites?
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Which type of immune cell is primarily responsible for releasing histamine during allergic reactions?
Which type of immune cell is primarily responsible for releasing histamine during allergic reactions?
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What happens to neutrophils after they have responded to an infection?
What happens to neutrophils after they have responded to an infection?
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What role do macrophages play in the immune system?
What role do macrophages play in the immune system?
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What is the primary role of memory lymphocytes in the immune system?
What is the primary role of memory lymphocytes in the immune system?
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Which statement best describes the function of basophils?
Which statement best describes the function of basophils?
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What significant discovery did Edward Jenner make related to vaccination?
What significant discovery did Edward Jenner make related to vaccination?
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Louis Pasteur's contributions to immunology include the development of which type of vaccination?
Louis Pasteur's contributions to immunology include the development of which type of vaccination?
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What distinguishes active vaccination from passive vaccination?
What distinguishes active vaccination from passive vaccination?
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Which of the following statements is true regarding passive vaccination?
Which of the following statements is true regarding passive vaccination?
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Emil von Behring is best known for his work in which area of immunology?
Emil von Behring is best known for his work in which area of immunology?
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What type of immunity does active vaccination aim to provide?
What type of immunity does active vaccination aim to provide?
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Which technique involves using antibodies extracted from an immunized individual to combat disease?
Which technique involves using antibodies extracted from an immunized individual to combat disease?
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Flashcards
Skin and mucous membranes
Skin and mucous membranes
They are part of the immune system's first line of defense, acting as a physical barrier to prevent pathogens from entering the body.
Macrophages
Macrophages
These cells patrol tissues and engulf pathogens, acting like tiny vacuum cleaners.
Inflammation
Inflammation
This is the body's immediate response to injury or infection, characterized by redness, swelling, heat, and pain.
Lymphocytes
Lymphocytes
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B cells
B cells
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Cytotoxic T cells
Cytotoxic T cells
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Dendritic cells
Dendritic cells
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Helper T cells
Helper T cells
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Self-tolerance
Self-tolerance
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First line of defense
First line of defense
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Phagocytic cells
Phagocytic cells
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Natural Killer (NK) cells
Natural Killer (NK) cells
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Immune memory
Immune memory
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Immunity
Immunity
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Pathogens
Pathogens
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What is phagocytosis?
What is phagocytosis?
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Neutrophils
Neutrophils
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Granulocytes
Granulocytes
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Eosinophils
Eosinophils
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Basophils
Basophils
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Mast Cells
Mast Cells
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Edward Jenner
Edward Jenner
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Louis Pasteur
Louis Pasteur
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Serotherapy
Serotherapy
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Active vaccination
Active vaccination
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Passive vaccination
Passive vaccination
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Active vaccination using attenuated pathogens
Active vaccination using attenuated pathogens
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Active vaccination using dead pathogens
Active vaccination using dead pathogens
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Natural Killer Cells
Natural Killer Cells
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Innate Immunity
Innate Immunity
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Adaptive Immunity
Adaptive Immunity
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Antigen
Antigen
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Primary Immune Response
Primary Immune Response
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Secondary Immune Response
Secondary Immune Response
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Physical Barriers
Physical Barriers
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Immunological Memory
Immunological Memory
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Cytokines
Cytokines
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Virus Titer
Virus Titer
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Study Notes
Introduction
- Thucydides recognized people who recovered from a disease were immune.
- The immune system protects against microscopic pathogens (like bacteria, fungi, and viruses).
- Cancer and pathogens affect evolution differently.
- Pathogens directly impact natural selection by favouring resistant individuals; cancers usually develop later after reproductive stage and don't hinder gene transmission.
- The immune system also plays a role in tissue repair and regeneration.
Defence Lines Immune System
- First line of defence includes skin and openings (eyes, ears, etc.) that act as barriers.
- Many pathogens can enter the body through openings.
- Second line of defence: white blood cells (leukocytes) act in areas of pathogen entry.
- Inflammation focuses on infection sites.
- Specific types of white blood cells are involved.
- NK cells kill virus-infected cells.
- Phagocytic cells engulf and destroy pathogens.
- Granulocytes release toxic substances to kill large pathogens (difficult to swallow).
Third Line of Defence
- Specialized white blood cells (lymphocytes) recognize and target pathogens.
- Lymphocytes develop a memory to recognize future similar pathogens.
- The "soldiers" B cells produce antibodies that identify pathogens, and cytotoxic T cells kill infected cells specifically.
- Commanders like dendritic cells capture pathogen fragments and present them to the other immune system cells to coordinate the response.
- Helper T cells coordinate the overall immune response.
Immune Defence Process
- First Line intact: Skin and mucous membranes prevent pathogen entry.
- Barrier Breakdown: Injury or infection allows pathogens to enter. Macrophages and dendritic cells detect invaders triggering inflammation.
- Arrival of additional white blood cells: Blood vessels dilate to allow white blood cells to reach the affected area.
- Activation of third line: Dendritic cells present antigens to lymphocytes for activation. B cells produce antibody and T cells destroy infected cells.
- Immune Memory: Memory lymphocytes rapidly respond to reinfection by the same pathogen.
Great Figures in Immunology
- Edward Jenner developed the first vaccine by recognizing cowpox protection from smallpox.
- Louis Pasteur discovered that diseases are caused by microorganisms, developed vaccines for rabies, anthrax, and cholera, and used attenuated pathogens.
- Emil von Behring demonstrated the effectiveness of serotherapy (using pre-made antibodies).
Active vs Passive Vaccination
- Active vaccination introduces antigens to stimulate the immune response, producing antibodies and memory cells for future protection.
- Passive vaccination provides pre-made antibodies for immediate, short-term protection, without stimulating the recipient's immune system.
Targets of the Immune System
- Intracellular infections: The immune system faces significant challenges targeting pathogens within infected cells, requiring cell-mediated responses.
- Extracellular infections: The immune system can target pathogens outside cells more readily.
Cells of the Immune System
- Phagocytes (Macrophages, neutrophils): Engulf and destroy pathogens through phagocytosis.
- Dendritic cells: Initiate the adaptive immune response by presenting antigens to T lymphocytes.
- Granulocytes (eosinophils, basophils, mast cells): Release toxic substances to kill pathogens, particularly parasites and involved in inflammatory and allergic responses.
- T lymphocytes (various types): Initiate and regulate immune responses and eliminate infected cells. B lymphocytes and NK cells.
Summary of Cells
- Summary of cells: Leukocytes include phagocytes (macrophages, neutrophils, dendritic cells, monocytes), granulocytes (basophils, eosinophils, mast cells), and lymphocytes (T cells, B cells, NK cells).
Lymphocytes
- T cells: Recognize specific antigens, and include subtypes like CD8 (cytotoxic), helping T cells and regulatory cells.
- B cells: Produce antibodies which attack pathogens.
- Natural Killer (NK) cells: Kill infected cells without prior sensitization.
Immune System Divisions
- The immune system is divided into innate and adaptive immunity.
- Innate: First line of defence, includes physical barriers, phagocytes, and complement proteins.
- Adaptive: Develops a specific response to a particular pathogen; includes B and T cells and has "immune memory".
Cytokine Concentration & Immune Responses
- Cytokines play a key role in immune responses, supporting both primary and secondary responses.
- Cytokines increase in secondary responses compared to primary ones due to recognition capability.
- Innate response is relatively faster but less specific. Adaptive response has memory for future attacks.
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Description
Test your knowledge on the immune system and its defense mechanisms. This quiz covers the different lines of defense, the role of various white blood cells, and how immunity works against pathogens. Perfect for students learning about biology and human health.