Podcast
Play an AI-generated podcast conversation about this lesson
Questions and Answers
Which receptors are considered the main activating receptors in T cells?
Which receptors are considered the main activating receptors in T cells?
- TCR complex and CD28 (correct)
- B7 molecules and CD28
- CD4+ and CD8+ T cells
- CTLA-4 and PD-1
What is the function of CTLA-4?
What is the function of CTLA-4?
- To enhance costimulation by CD28
- To activate responding T cells
- To suppress the activation of responding T cells (correct)
- To remove B7 molecules from the surface of APCs
Which receptor has a higher affinity for B7 molecules than CD28?
Which receptor has a higher affinity for B7 molecules than CD28?
- CTLA-4 (correct)
- TCR complex
- PD-1
- CD4+
Which receptors on T cells are currently being tested as targets of checkpoint blockade therapy?
Which receptors on T cells are currently being tested as targets of checkpoint blockade therapy?
Signup and view all the answers
What is the role of PD-1 in situations of chronic or repeated antigenic stimulation?
What is the role of PD-1 in situations of chronic or repeated antigenic stimulation?
Signup and view all the answers
What is the term used to describe the therapy that blocks inhibitory receptors to enhance antitumor immune responses?
What is the term used to describe the therapy that blocks inhibitory receptors to enhance antitumor immune responses?
Signup and view all the answers
What is the function of regulatory T cells?
What is the function of regulatory T cells?
Signup and view all the answers
