Functional Roles of Cannabinoid Receptors Quiz
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Questions and Answers

Which neuroadaptive state occurs in response to long-term occupation of opioid receptors?

  • Sensitization
  • Dependence (correct)
  • Tolerance
  • Hyperactivity

    • What is a common symptom of opioid withdrawal related to pain and irritability?

  • Restlessness and insomnia (correct)
  • Tranquilization
  • Relaxation and sleep
  • Euphoria

    • Which effect is NOT associated with acute opioid use?

  • Pupil constriction
  • Increased blood pressure (correct)
  • Pupil dilation
  • Diarrhea

    • What is the primary effect of opioids on adenylyl cyclase and cAMP production?

    <p>Inhibit production</p> Signup and view all the answers

    Which drug is mentioned as the most potent in the text regarding hallucinogens?

    <p>LSD</p> Signup and view all the answers

    What is a common consequence of taking hallucinogenic drugs orally?

    <p>Delayed onset of action by 30-90 minutes</p> Signup and view all the answers

    What is responsible for cannabinoid-induced memory impairment?

    <p>Hippocampal CB1 receptors</p> Signup and view all the answers

    Which neurotransmitter is a full agonist at both CB1 and CB2 receptors?

    <p>2-AG</p> Signup and view all the answers

    What is the impact of endocannabinoids on anxiety responses?

    <p>They are important mediators of anxiety responses</p> Signup and view all the answers

    Which cannabinoid acts as a negative allosteric modulator of CB1 receptors?

    <p>CBD</p> Signup and view all the answers

    What is the effect of THC on regional brain activation based on brain imaging?

    <p>Promotes regional brain activation and enhanced local blood flow</p> Signup and view all the answers

    Which cognitive functions can be affected by marijuana use according to the text?

    <p>Learning, memory, attention, and decision making</p> Signup and view all the answers

    What cognitive process is impaired both acutely and chronically by cannabinoid exposure?

    <p>Verbal learning and memory</p> Signup and view all the answers

    Which cognitive process shows possibly persistent effects according to the text?

    <p>Verbal learning and memory</p> Signup and view all the answers

    In chronic cannabinoid exposure, what cognitive process may be impaired depending on the frequency of use and age of onset?

    <p>Attention</p> Signup and view all the answers

    Which cognitive process is likely to show persistent effects on attention and psychomotor function with abstinence?

    <p>Psychomotor function</p> Signup and view all the answers

    What effect of cannabinoid exposure is task- and dose-dependent according to the text?

    <p>Impaired attention</p> Signup and view all the answers

    Which cognitive process shows possibly impaired executive function as a chronic effect of cannabinoid exposure?

    <p>Impaired inhibitory control</p> Signup and view all the answers

    What potentially dangerous cardiovascular effects can be seen when α1 blockade is coupled with NE reuptake-blocking?

    <p>Tachycardia and arrhythmias</p> Signup and view all the answers

    Which side effect is specifically associated with Selective Serotonin Reuptake Inhibitors (SSRIs)?

    <p>Nausea and headache</p> Signup and view all the answers

    What life-threatening condition can occur when SSRIs are combined with other serotonergic agonists or drugs?

    <p>Serotonin syndrome</p> Signup and view all the answers

    What is the primary advantage of Dual NE/5-HT modulators (SNRIs) over SSRIs according to the text?

    <p>Enhancing both NE and 5-HT function</p> Signup and view all the answers

    How does Mirtazapine reduce side effects according to the text?

    <p>It blocks only selected 5-HT receptors</p> Signup and view all the answers

    What effect does blocking α2-autoreceptors have on serotonergic cells?

    <p>Increases 5-HT release</p> Signup and view all the answers

    What is the best predictor of a good therapeutic response to psychedelic drugs?

    <p>Intensity of the psychedelic experience</p> Signup and view all the answers

    How do PCP and ketamine act as antagonists at the NMDA receptor?

    <p>They bind to a site within the receptor's channel</p> Signup and view all the answers

    What effect does the NMDA receptor blockade by PCP and ketamine have on cortical GABAergic interneurons?

    <p>Increases cortical glutamate release</p> Signup and view all the answers

    What is a common symptom induced by high doses of PCP and ketamine, resembling schizophrenia?

    <p>Disordered thought and motor disturbances</p> Signup and view all the answers

    What is hypothesized as a key factor in the glutamate hypothesis of schizophrenia?

    <p>Underactivity of the glutamatergic system</p> Signup and view all the answers

    What effect did researchers find in human volunteers without prior exposure to ketamine?

    <p>Dose-independent increase in drug liking</p> Signup and view all the answers

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