Immune Mediated Diseases Quiz
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Questions and Answers

Which immune mediated disease is associated with immune complex deposition in synovial basement membrane?

  • Ehrlichia
  • Leishmania
  • IMPA (correct)
  • Babesia

What is the type of hypersensitivity reaction involved in IMPA?

  • Type I
  • Type II
  • Type IV
  • Type III (correct)

Which type of IMPA is most common and has no identified trigger?

  • Type III
  • Type I (correct)
  • Type IV
  • Type II

Which type of IMPA is associated with infection remote from joints?

<p>Type II (B)</p> Signup and view all the answers

Which type of IMPA is associated with inflammatory GI disease?

<p>Type III (D)</p> Signup and view all the answers

Which type of IMPA is associated with neoplastic disease?

<p>Type IV (D)</p> Signup and view all the answers

What is one of the diagnostic clues for glomerular disease in relation to IMPA?

<p>Proteinuria on urinalysis (A)</p> Signup and view all the answers

What is one of the diagnostic clues for skin lesions in relation to IMPA?

<p>Cutaneous bruising (B)</p> Signup and view all the answers

What is one of the diagnostic clues for IMHA (Evan’s Syndrome) in relation to IMPA?

<p>Anaemia (A)</p> Signup and view all the answers

Why is prompt treatment important for IMPA?

<p>To reverse the disease (C)</p> Signup and view all the answers

Which of the following is an example of an immune mediated disease in dogs?

<p>Immune mediated thrombocytopenia (D)</p> Signup and view all the answers

What is the main difference between immune mediated disease and autoimmune disease?

<p>The type of immune response involved (A)</p> Signup and view all the answers

Which of the following is an example of an immune mediated disease in humans?

<p>Rheumatoid arthritis (D)</p> Signup and view all the answers

What is the term used to describe immune mediated destruction of adrenal glands in dogs?

<p>Addison's disease (C)</p> Signup and view all the answers

Which of the following is an example of irreversible immune mediated disease in dogs?

<p>Exocrine pancreatic insufficiency (C)</p> Signup and view all the answers

Which of the following is an example of an immune mediated disease affecting the thyroid gland?

<p>Grave's disease (D)</p> Signup and view all the answers

What is the term used to describe the destruction of pancreatic islet cells in humans?

<p>Type I diabetes (C)</p> Signup and view all the answers

Which of the following is an example of an immune mediated disease affecting the joints in dogs?

<p>Immune mediated polyarthritis (B)</p> Signup and view all the answers

What is the term used to describe the immune mediated destruction of thyroid follicular epithelium in humans?

<p>Hypothyroidism (D)</p> Signup and view all the answers

Which type of hypersensitivity is characterized by immune complex deposition in the renal glomerulus, synovium, or uveal tract?

<p>Type III hypersensitivity (A)</p> Signup and view all the answers

Which of the following is NOT an example of a multisystemic immune mediated disease in dogs?

<p>Hypothyroidism (D)</p> Signup and view all the answers

What is the primary trigger for idiopathic immune mediated disease?

<p>Unknown (C)</p> Signup and view all the answers

Which age group of dogs is more likely to develop immune mediated diseases?

<p>Mid to older age (A)</p> Signup and view all the answers

Which type of immune response is associated with the destruction of thyroid tissue in hypothyroidism?

<p>Type IV hypersensitivity (A)</p> Signup and view all the answers

What is the mechanism of red blood cell destruction in immune mediated hemolytic anemia (IMHA)?

<p>Type II hypersensitivity (A)</p> Signup and view all the answers

What is the main difference between primary and secondary immune mediated diseases?

<p>Primary diseases have a known trigger, while secondary diseases do not. (B)</p> Signup and view all the answers

What is the pathophysiology of immune-mediated polyarthritis (IMPA)?

<p>The pathophysiology of IMPA involves a type III hypersensitivity reaction, immune complex deposition in synovial basement membrane, complement cascade activation, recruitment of inflammatory cells, and release of nitric oxide, free radicals, and proteases leading to tissue damage.</p> Signup and view all the answers

What is the significance of prompt treatment for IMPA?

<p>Prompt treatment for IMPA is important because it is potentially reversible and if a trigger antigen is found and/or an underlying cause can be treated, it could avoid the use of immune suppressive drugs.</p> Signup and view all the answers

How is IMPA categorized according to trigger factors?

<p>IMPA is categorized according to trigger factors into Type I (idiopathic), Type II (associated with infection remote from joints), Type III (associated with inflammatory GI disease), Type IV (associated with neoplastic disease), and as part of a multi-systemic immune-mediated disease.</p> Signup and view all the answers

What are the three types of hypersensitivity reactions involved in immune mediated diseases?

<p>Type II, Type III, Type IV</p> Signup and view all the answers

What are the recognized genetic predispositions for immune mediated diseases in dogs?

<p>Cocker Spaniel: IMHA, IMT, hypothyroidism, keratoconjunctivitis sicca, immune mediated pancreatitis</p> Signup and view all the answers

What are the age-related changes to the immune system that make mid to older age dogs more likely to get immune mediated diseases?

<p>Reduction in cell mediated immunity, shift in balance of circulating T cells</p> Signup and view all the answers

What are the possible triggers for secondary immune mediated diseases?

<p>Infection, drugs, neoplastic disease, inflammation, vaccine</p> Signup and view all the answers

What is the link between chronic pancreatitis/enteropathy and immune mediated cytopenias?

<p>Chronic pancreatitis/enteropathy is associated with immune mediated cytopenias</p> Signup and view all the answers

What is the definition of immune mediated disease?

<p>An immune mediated disease refers to a condition where the body's immune response targets its own healthy cells and organs.</p> Signup and view all the answers

What is the failure that occurs in immune mediated disease?

<p>The failure of the mechanisms that underpin 'self-tolerance'.</p> Signup and view all the answers

Provide three examples of immune mediated diseases in dogs.

<p>Autoimmune or immune mediated hemolytic anemia (IMHA), Immune mediated thrombocytopenia (IMT), Immune mediated polyarthritis (IMPA).</p> Signup and view all the answers

What is the management approach for reversible immune mediated diseases?

<p>Treatment is aimed at reducing or controlling the abnormal or aberrant immune response to improve clinical signs of disease.</p> Signup and view all the answers

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