17 Questions
What is the most common finding in the electron microscopy (EM) of IgA nephropathy?
Electron-dense deposits in the mesangium
What is the most common clinical presentation of IgA nephropathy?
Asymptomatic microhematuria with intermittent gross hematuria
Which of the following is the most common trigger for episodic gross hematuria in IgA nephropathy?
All of the above
What is the most common histological finding in IgA nephropathy?
Mesangial hypercellularity
Which of the following is the most common underlying mechanism in the pathogenesis of IgA nephropathy?
Deposition of immune complexes in the mesangium
Which of the following is the most common systemic disease associated with IgA nephropathy?
Henoch-Schönlein purpura
How is rapidly proliferating GN characterized?
Severe oliguria and rapid loss of renal function
Which type of immune complex deposition is seen in Type II RPGN?
Deposition along the glomerular basement membrane (GBM)
What are the criteria for diagnosing rapidly progressive glomerulonephritis (RPGN)?
Severe oliguria and progressive renal function loss
What is the characteristic feature of Type III RPGN?
Presence of antineutrophil cytoplasmic antibodies (ANCAs) in serum
What results from the proliferation of parietal epithelial cells in glomeruli?
Presence of fibrous crescents
What is the histologic hallmark in glomerulonephritis associated with vasculitides?
Development of widespread crescents
What is the most common cause of death in Systemic Lupus Erythematosus (SLE)?
Renal failure
Which condition is characterized by antibodies directed against negatively charged phospholipid-protein complexes?
Post-streptococcal Glomerulonephritis
What is the primary pathophysiological mechanism in glomerular thrombosis?
Immune complex deposition
Which renal condition presents with peripheral eosinophilia and c-ANCA antibodies?
Wegener's Granulomatosis
In which autoimmune disease does autoimmunity play a major role with antibodies against nuclear elements forming immune complexes?
Lupus Nephritis
Learn about IgA Nephropathy, the most common idiopathic glomerulonephritis worldwide, characterized by episodic gross hematuria and elevated plasma concentrations of IgA. Discover its occurrence, peak incidence, and progression to end-stage renal disease (ESRD).
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