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IgA Nephropathy (Bergers disease)

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Questions and Answers

What is the most common finding in the electron microscopy (EM) of IgA nephropathy?

Electron-dense deposits in the podocytes

Electron-dense deposits in the tubular basement membrane

Electron-dense deposits in the mesangium (correct)

Electron-dense deposits in the glomerular basement membrane

What is the most common clinical presentation of IgA nephropathy?

Asymptomatic microhematuria with intermittent gross hematuria (correct)

Acute kidney injury

Hypertension

Nephrotic syndrome

Which of the following is the most common trigger for episodic gross hematuria in IgA nephropathy?

Viral upper respiratory tract infection

Bacterial gastroenteritis

Strenuous exercise

All of the above (correct)

What is the most common histological finding in IgA nephropathy?

Mesangial hypercellularity Signup and view all the answers

Which of the following is the most common underlying mechanism in the pathogenesis of IgA nephropathy?

Deposition of immune complexes in the mesangium Signup and view all the answers

Which of the following is the most common systemic disease associated with IgA nephropathy?

Henoch-Schönlein purpura Signup and view all the answers

How is rapidly proliferating GN characterized?

Severe oliguria and rapid loss of renal function Signup and view all the answers

Which type of immune complex deposition is seen in Type II RPGN?

Deposition along the glomerular basement membrane (GBM) Signup and view all the answers

What are the criteria for diagnosing rapidly progressive glomerulonephritis (RPGN)?

Severe oliguria and progressive renal function loss Signup and view all the answers

What is the characteristic feature of Type III RPGN?

Presence of antineutrophil cytoplasmic antibodies (ANCAs) in serum Signup and view all the answers

What results from the proliferation of parietal epithelial cells in glomeruli?

Presence of fibrous crescents Signup and view all the answers

What is the histologic hallmark in glomerulonephritis associated with vasculitides?

Development of widespread crescents Signup and view all the answers

What is the most common cause of death in Systemic Lupus Erythematosus (SLE)?

Renal failure Signup and view all the answers

Which condition is characterized by antibodies directed against negatively charged phospholipid-protein complexes?

Post-streptococcal Glomerulonephritis Signup and view all the answers

What is the primary pathophysiological mechanism in glomerular thrombosis?

Immune complex deposition Signup and view all the answers

Which renal condition presents with peripheral eosinophilia and c-ANCA antibodies?

Wegener's Granulomatosis Signup and view all the answers

In which autoimmune disease does autoimmunity play a major role with antibodies against nuclear elements forming immune complexes?

Lupus Nephritis Signup and view all the answers