IgA Nephropathy (Bergers disease)

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Questions and Answers

What is the most common finding in the electron microscopy (EM) of IgA nephropathy?

  • Electron-dense deposits in the podocytes
  • Electron-dense deposits in the tubular basement membrane
  • Electron-dense deposits in the mesangium (correct)
  • Electron-dense deposits in the glomerular basement membrane

What is the most common clinical presentation of IgA nephropathy?

  • Asymptomatic microhematuria with intermittent gross hematuria (correct)
  • Acute kidney injury
  • Hypertension
  • Nephrotic syndrome

Which of the following is the most common trigger for episodic gross hematuria in IgA nephropathy?

  • Viral upper respiratory tract infection
  • Bacterial gastroenteritis
  • Strenuous exercise
  • All of the above (correct)

What is the most common histological finding in IgA nephropathy?

<p>Mesangial hypercellularity (D)</p> Signup and view all the answers

Which of the following is the most common underlying mechanism in the pathogenesis of IgA nephropathy?

<p>Deposition of immune complexes in the mesangium (B)</p> Signup and view all the answers

Which of the following is the most common systemic disease associated with IgA nephropathy?

<p>Henoch-Schönlein purpura (B)</p> Signup and view all the answers

How is rapidly proliferating GN characterized?

<p>Severe oliguria and rapid loss of renal function (B)</p> Signup and view all the answers

Which type of immune complex deposition is seen in Type II RPGN?

<p>Deposition along the glomerular basement membrane (GBM) (C)</p> Signup and view all the answers

What are the criteria for diagnosing rapidly progressive glomerulonephritis (RPGN)?

<p>Severe oliguria and progressive renal function loss (B)</p> Signup and view all the answers

What is the characteristic feature of Type III RPGN?

<p>Presence of antineutrophil cytoplasmic antibodies (ANCAs) in serum (D)</p> Signup and view all the answers

What results from the proliferation of parietal epithelial cells in glomeruli?

<p>Presence of fibrous crescents (B)</p> Signup and view all the answers

What is the histologic hallmark in glomerulonephritis associated with vasculitides?

<p>Development of widespread crescents (A)</p> Signup and view all the answers

What is the most common cause of death in Systemic Lupus Erythematosus (SLE)?

<p>Renal failure (B)</p> Signup and view all the answers

Which condition is characterized by antibodies directed against negatively charged phospholipid-protein complexes?

<p>Post-streptococcal Glomerulonephritis (B)</p> Signup and view all the answers

What is the primary pathophysiological mechanism in glomerular thrombosis?

<p>Immune complex deposition (B)</p> Signup and view all the answers

Which renal condition presents with peripheral eosinophilia and c-ANCA antibodies?

<p>Wegener's Granulomatosis (A)</p> Signup and view all the answers

In which autoimmune disease does autoimmunity play a major role with antibodies against nuclear elements forming immune complexes?

<p>Lupus Nephritis (B)</p> Signup and view all the answers

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