12 Questions
What is the main role of CRH in the stress response?
Regulating cortisol levels
Where does ACTH induce glucocorticoid synthesis?
Adrenal cortex
What happens to the secretion of CRH and ACTH due to feedback from glucocorticoids during prolonged stress?
It does not change
What is the condition called when stress-induced ACTH and glucocorticoid hypersecretion fail to inhibit additional pituitary ACTH secretion?
Permissive facilitation
Apart from ACTH, what other factors influence glucocorticoid secretion?
Vasopressin and angiotensin
In which brain area does multiple external and internal stimuli activate neurons to synthesize and secrete CRH?
Paraventricular hypothalamic nucleus
What is the major role of glucocorticoids?
Mobilization of energy stores
What can cortisol levels reach within a few hours of starting major surgery?
Four- to five-fold the normal baseline value
Which hormone has a more potent mineralocorticoid effect than cortisol?
Aldosterone
What stimulates the production of aldosterone?
Stress induced CRH and ACTH secretion
What happens to aldosterone production after several hours of sustained adrenal cortex stimulation by ACTH?
Begins to wane and returns to normal or low levels within 24 hours
What does RAAS stimulation induce?
Sustained higher concentrations of aldosterone
This quiz covers the activation of neurons in the paraventricular hypothalamic nucleus to synthesize and secrete CRH, and the role of CRH in the stress response beyond the HPA axis. It also includes the transportation of ACTH to the adrenal cortex and its effects.
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