18 Questions
Which pathway involves the absorption of cholesterol from dietary sources?
Exogenous pathway
What percentage of total circulating cholesterol exists in the form of cholesterol esters?
70%
Where is cholesterol synthesized in the endogenous pathway?
Liver
Which part of a cholesterol molecule enhances its hydrophobicity?
Long chain fatty acid residue
What is the actual concentration of plasma cholesterol in healthy individuals?
150-200 mg/dl
Which component of lipoproteins does cholesterol circulate as?
Cholesterol esters
Which of the following is NOT a function of cholesterol mentioned in the text?
Synthesis of amino acids
Where is cholesterol primarily synthesized de novo in the body?
Liver
What is the primary source of cholesterol for non-hepatic cells?
Low density lipoproteins (LDL)
Which regulatory mechanism inactivates HMG-CoA reductase due to dietary cholesterol?
Allosteric regulation
What provides the reducing equivalents for the synthesis of cholesterol?
NADPH
Why can't humans metabolize the cholesterol ring structure to carbon dioxide and water?
Lack of enzymes for the process
What happens to the intact steroid nucleus in the body?
It is converted to bile acids and bile salts.
What is the term used to refer to a high blood cholesterol level?
Hypercholesterolemia
What can happen if excess cholesterol is not managed?
Deposition under the skin and tendons as Xanthomas
What causes some people to suffer from hypercholesterolemia at a young age?
Genetic disorders affecting HMG-CoA reductase
How can hypercholesterolemia often be prevented?
Exercising regularly and following a low-fat diet
When diet and exercise fail to reduce cholesterol levels, what may be recommended?
Cholesterol lowering medications
Test your knowledge on hypercholesterolemia, cholesterol metabolism, atherosclerosis, Xanthomas, and the role of HMG-CoA reductase enzyme. Learn about the risks associated with high blood cholesterol levels.
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