Human Physiology Quiz

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Questions and Answers

What is the primary focus of the provided information?

  • Detailed analysis of all blood components.
  • A broad discussion of all blood disorders.
  • An overview of immunology and immune cell types.
  • Specific information relating to red blood cells. (correct)

Which academic discipline is most directly related to the content?

  • Haematology (correct)
  • Cardiology
  • Neurology
  • Oncology

What type of professional expertise is indicated by the title 'Assoc.Prof.Dr.'?

  • A laboratory technician
  • A senior specialist in their field (correct)
  • A research assistant
  • A junior lecturer

If this were a lecture, what would most likely be the following topic?

<p>The role of red blood cells in disease (C)</p> Signup and view all the answers

In what type of academic setting would this content be found?

<p>A specialized medical course (C)</p> Signup and view all the answers

What percentage of blood volume is typically made up by plasma?

<p>Approximately 55% (D)</p> Signup and view all the answers

Which of the following is NOT a primary function associated with blood, as described in the text?

<p>Osmolarity control (C)</p> Signup and view all the answers

If a person has a body weight of 70kg, what would be the approximate total blood volume, based on the information contained in this document?

<p>5.6 litres (C)</p> Signup and view all the answers

What is the approximate percentage of protein that is found in blood plasma?

<p>7% (B)</p> Signup and view all the answers

What is the pH range of blood plasma?

<p>7.35 - 7.45 (D)</p> Signup and view all the answers

What is the primary function of hemoglobin in red blood cells?

<p>Binding and transporting oxygen from the lungs to the tissues. (B)</p> Signup and view all the answers

Which of the following statements about the production of red blood cells (RBCs) is CORRECT?

<p>RBC production requires the presence of hormones, such as erythropoietin, and vitamins like B12 and folate. (B)</p> Signup and view all the answers

How many oxygen molecules can a single hemoglobin molecule bind?

<p>4 (C)</p> Signup and view all the answers

Why do red blood cells lack mitochondria?

<p>Red blood cells derive their energy primarily from anaerobic metabolism. (B)</p> Signup and view all the answers

Which of the following factors can directly influence the production of red blood cells?

<p>The levels of certain hormones, such as erythropoietin, in the blood. (A)</p> Signup and view all the answers

What is the primary role of the liver in the context of blood function?

<p>To filter waste products for excretion (A)</p> Signup and view all the answers

Which of these best describes the term 'homeostasis' as it relates to the blood?

<p>The process of maintaining a stable internal environment in the body. (A)</p> Signup and view all the answers

If a patient has a total blood volume of approximately 5 liters, what percentage of this volume is typically composed of cells?

<p>8% (C)</p> Signup and view all the answers

If the body’s internal environment is disturbed, what term describes the action/mechanisms that restore balance?

<p>Homeostatic (D)</p> Signup and view all the answers

Which of the following is a key function of white blood cells (WBC) as indicated in the content?

<p>Providing immunity. (C)</p> Signup and view all the answers

Based on its description, what type of tissue is blood?

<p>Special connective tissue (C)</p> Signup and view all the answers

Besides temperature, what other homeostatic regulation function is explicitly mentioned in the content?

<p>Maintaining pH (B)</p> Signup and view all the answers

What is the primary characteristic of blood described in the content, besides it being a special connective tissue?

<p>Viscous (A)</p> Signup and view all the answers

What is the primary function of blood regarding nutrients and oxygen?

<p>To supply oxygen and nutrients to body tissues. (A)</p> Signup and view all the answers

What term describes the percentage of red blood cells in the total blood volume?

<p>Hematocrit (C)</p> Signup and view all the answers

Which of the following is NOT explicitly identified as a formed element found in blood?

<p>Plasma Proteins (D)</p> Signup and view all the answers

Besides supplying nutrients and oxygen, what other primary function does blood have?

<p>Homeostatic regulation (B)</p> Signup and view all the answers

Based on the information, which of the following is true regarding the hematocrit?

<p>Normal hematocrit percentage is higher in males than females (A)</p> Signup and view all the answers

Which characteristic of blood is indicated by the term 'polarity' in the listed information?

<p>A blood quality that influences its ability to transport substances. (D)</p> Signup and view all the answers

What does the text indicate about blood as a type of body tissue?

<p>It is a type of connective tissue. (A)</p> Signup and view all the answers

What is the primary focus of the discussed blood's homeostatic function?

<p>To maintain a stable internal environment. (D)</p> Signup and view all the answers

What is the primary function of albumin in plasma?

<p>Osmotic pressure and carrier function (C)</p> Signup and view all the answers

How do erythrocytes contribute to the regulation of the body's pH?

<p>Through the action of the enzyme carbonic anhydrase, which catalyzes the conversion of carbon dioxide and water to bicarbonate ions. (B)</p> Signup and view all the answers

Which of the following accurately describes the relationship between erythrocytes and platelets?

<p>Platelets and erythrocytes are both formed elements of blood, but they have distinct functions. Platelets are responsible for clot formation, while erythrocytes transport oxygen. (A)</p> Signup and view all the answers

A patient presents with a low red blood cell count (anemia). Which of the following may be a contributing factor to this condition?

<p>Deficiency in iron or vitamin B12. (B)</p> Signup and view all the answers

Which of the following statements accurately describes the function of globulins in plasma?

<p>Globulins are involved in immune responses and act as carriers for certain substances. (D)</p> Signup and view all the answers

What is the average lifespan of a red blood cell?

<p>Approximately 120 days (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of erythrocytes?

<p>Active division and proliferation (D)</p> Signup and view all the answers

Flashcards

What are Red Blood Cells (RBCs)?

Red blood cells (RBCs) are essential components of blood, responsible for carrying oxygen from the lungs to the rest of the body.

What is Haematology?

Haematology is the branch of medicine specializing in the study, diagnosis, treatment, and prevention of diseases related to blood, blood-forming organs, and blood disorders.

What is Immunity?

Immunity is the body's natural defense system against foreign invaders like bacteria, viruses, and parasites. It helps protect us from infections and diseases.

Where are Red Blood Cells produced?

RBCs are produced in the bone marrow, a soft tissue found inside bones.

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What is the shape of Red Blood Cells?

RBCs are biconcave in shape, meaning they have a flattened, disc-like appearance that helps them efficiently carry oxygen and move through blood vessels.

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What is blood?

A specialized connective tissue responsible for transporting oxygen, nutrients, and waste products throughout the body.

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What is homeostasis?

The process of maintaining a stable internal environment in the body, like temperature, pH, and fluid levels.

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What are homeostatic mechanisms?

The mechanisms or actions that help maintain homeostasis, like sweating to cool down or shivering to warm up.

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How does blood regulate temperature?

One of the functions of blood is to regulate body temperature. Blood can absorb heat from metabolic processes and distribute it throughout the body.

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How does blood regulate pH?

Blood helps to maintain a stable pH balance in the body. This is crucial for the proper functioning of enzymes and other biological processes.

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How does blood transport waste?

Blood carries waste products from cells, like carbon dioxide and urea, to the kidneys and liver for excretion.

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How does blood contribute to immunity?

Immunity is the body's defense system against foreign invaders like bacteria and viruses. WBCs are a crucial part of the immune system.

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What is blood volume?

Blood's volume is a measure of its total amount. It's crucial for maintaining blood pressure and circulation.

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Osmolarity

The concentration of dissolved particles in a fluid. Think of it as the amount of 'stuff' dissolved in the liquid. This is an important aspect of maintaining fluid balance in the body.

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Hemostasis

The process of stopping bleeding, essential for preventing excessive blood loss and maintaining blood vessel integrity.

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Hematocrit

The percentage of red blood cells in the blood. Think of it as the ratio of red blood cells to the total blood volume.

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Plasma

The liquid component of blood, containing water, proteins, inorganic ions, and other dissolved substances.

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Blood pH

The normal blood pH ranges from 7.35 to 7.45. This is slightly alkaline, crucial for proper function of cells and enzymes. A slightly basic blood pH is crucial for proper function of cells and enzymes.

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What is hematocrit?

Hematocrit is the percentage of red blood cells (RBCs) in the blood.

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What is plasma?

Plasma is the liquid component of blood, comprising about 55% of blood volume.

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What are the components of plasma?

Plasma is primarily composed of water, but also contains proteins, electrolytes, nutrients, hormones, and waste products.

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Describe the physical characteristics of RBCs.

Red blood cells (RBCs) are biconcave discs that lack a nucleus and other organelles, with a lifespan of around 120 days.

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What process creates new red blood cells?

Erythropoiesis, or red blood cell production, primarily takes place in the bone marrow.

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What is the main function of red blood cells?

Red blood cells are crucial for transporting oxygen from the lungs to the tissues and carbon dioxide from the tissues back to the lungs.

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How does blood homeostasis relate to red blood cell disorders?

Disorders like anemia, polycythemia, and sickle cell disease are related to abnormalities in red blood cell production, function, or shape.

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How do RBCs generate energy?

Red blood cells lack mitochondria and generate ATP through anaerobic respiration.

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Do mature red blood cells have a nucleus?

Mature red blood cells lack a nucleus, which allows more space for hemoglobin.

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How many oxygen molecules can one red blood cell carry?

Each red blood cell can carry approximately 1 billion oxygen molecules. This is due to the presence of hemoglobin, a protein that binds to oxygen.

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How many amino acids are in a hemoglobin subunit?

Hemoglobin, the protein responsible for oxygen transport in red blood cells, consists of 146 amino acids in each of its four subunits.

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Describe the journey of RBC formation.

The production of red blood cells is a complex process that starts with stem cells in the bone marrow. Erythropoietin, a hormone, stimulates this process. Vitamin B12, folic acid, and iron are essential for the synthesis of hemoglobin.

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What is Albumin?

Albumin is a plasma protein that contributes to maintaining osmotic pressure and acts as a carrier for various substances.

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What is Globulin?

Globulins are a type of plasma protein responsible for immune functions and transport of various substances.

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What is Fibrinogen?

Fibrinogen is a plasma protein that plays a crucial role in blood clotting by converting into fibrin.

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What are Hemocytoblasts?

Hemocytoblasts are the precursor cells in the bone marrow that differentiate into various mature blood cells, including red blood cells, white blood cells, and platelets.

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What is the primary function of red blood cells?

Red blood cells, also known as erythrocytes, are responsible for carrying oxygen from the lungs to the body's tissues.

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What is the function of the Carbonic anhydrase in red blood cells?

Carbonic anhydrase is an enzyme found in red blood cells that helps to convert carbon dioxide into bicarbonate, a form suitable for transport in the blood.

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What cellular components do red blood cells lack?

Red blood cells lack RNA and ribosomes, which are essential for protein synthesis.

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Study Notes

Haematology & Immunity - RBCs

  • Haematology and Immunity is a course covering Red Blood Cells (RBCs).
  • The course is taught by Assoc. Prof. Dr. Hassaan A. Rathore, PhD.
  • The course code is HSF-II / MEDI103.
  • The institution is Qatar University, College of Pharmacy.
  • The course covers blood composition, function, characteristics, and RBC formation.

Course Outline

  • Week 1 (January 19-23): Blood composition and function, blood components' characteristics, blood volume, plasma functions, formed elements (erythrocytes, leucocytes).
  • No Lab: No lab activities during Week 1.
  • Week 2 (January 26-30): Hemostasis (vascular spasm, platelet plug formation, coagulation cascade, clot retraction, fibrinolysis), factors limiting clot growth, blood disorders, blood groups, transfusion reactions.
  • No Lab: No lab activities during Week 2.

Learning Outcomes

  • Describe blood composition and circulating blood volume.
  • Explain plasma composition and function.
  • Describe RBC physical characteristics.
  • Describe RBC function and formation (erythropoiesis).
  • Relate blood homeostasis to RBC disorders.

Blood Composition

  • Blood is a "special connective tissue" that's viscous.
  • Blood is approximately 8% of body weight (4.5-6 liters).
  • Blood is composed of cells (RBCs, WBCs, platelets) and plasma.
  • Male hematocrit (RBC percentage): 42%-52%
  • Female hematocrit (RBC percentage): 37%-47%

Plasma Composition

  • Plasma (55% of blood): Mostly water (91.5%).
  • Plasma contains proteins (7%), inorganic ions (1.5%), organic substances (glucose, amino acids, vitamins, lipids), and hormones.

Plasma Proteins

  • Albumin: Maintains osmotic pressure, involved in carrying substances.
  • Globulin: Plays a role in immunity; carries substances.
  • Fibrinogen: Involved in blood clotting.

Formed Elements - Differentiation

  • Formed elements (RBCs, WBCs, platelets) originate from pluripotent stem cells in bone marrow.
  • RBCs (erythrocytes) are formed through erythropoiesis.

RBC Functions

  • Transport oxygen from lungs to the body's tissues (hemoglobin).
  • Transport carbon dioxide from tissues to the lungs (carbonic anhydrase).

RBC Characteristics

  • Thin biconcave discs (diameter ~8 µm).
  • No nucleus in mature RBCs; this allows for maximum hemoglobin space for oxygen transport.
  • Volume: ~90 fL.
  • Life span: ~120 days.
  • Lack RNA, ribosomes, mitochondria. Produce ATP anaerobically.
  • Normal concentration: Male 5 million /µL, Female 4.7 million /µL (RBCs / mm³ ± 5,000,000).

Hemoglobin (Hb)

  • Each RBC contains ~280 million Hb molecules.
  • Hb can bind four oxygen molecules.
  • Hb molecule structure: Heme group, iron, alpha and beta chains.

Erythropoiesis

  • The process of RBC production.
  • Stem cells (hemocytoblasts) → Proerythroblast → Basophilic erythroblast → Polychromatophil erythroblast → Normoblast → Reticulocyte → Mature RBC.
  • Erythropoietin (EPO) is a hormone crucial for erythropoiesis.

RBC Homeostasis

  • Stimulus: low oxygen.
  • Kidney (and liver) detect low oxygen.
  • Kidney releases EPO & Erythropoietin (EPO) stimulates bone marrow. This increases RBC production.
  • Enhanced erythropoiesis = increased RBC count; oxygen-carrying ability of blood increases.

RBC Destruction

  • Old RBCs become fragile and are destroyed (mostly in spleen).
  • Components are recycled: hemoglobin → heme → iron & globin.

RBC Disorders (Anemia)

  • General definition: Reduction in RBC count or Hb concentration, leading to reduced oxygen-carrying capacity.
  • Types:
    • Blood loss anemia
    • Aplastic anemia
    • Pernicious anemia
    • Haemolytic anemia (sickle cell anemia, thalassemia).

Physiologic Effects of Anemia

  • Cardiac output changes due to blood viscosity.
  • Hypoxia worsens during physical exertion.
  • Potential for cardiac failure.

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