Human Pathology 4142: Bone Disorders Quiz
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Questions and Answers

Metastatic tumours are by far more common than primary bone tumours.

True

Many bone metastases are asymptomatic, and the clinical effects are mainly pain and bone destruction.

True

In adults, over 75% of skeletal metastases originate from cancers of the thyroid, prostate, breast, kidney, and lung.

True

Metastatic disease in children most commonly derives from neuroblastoma, Wilms tumour, Ewing sarcoma, and rhabdomyosarcoma.

<p>True</p> Signup and view all the answers

Osteosarcoma is one of the least common malignant tumours of bone.

<p>False</p> Signup and view all the answers

Osteosarcoma typically occurs at ages between 10-25 years and mainly affects the metaphysis of long bones, particularly around the knee joint.

<p>True</p> Signup and view all the answers

Osteosarcoma can exhibit osteoblastic, chondroblastic, or fibroblastic differentiation.

<p>True</p> Signup and view all the answers

Chondrosarcoma is the most common malignant matrix-producing bone tumor.

<p>False</p> Signup and view all the answers

Ewing's sarcoma usually arises in the metaphysis of long bones.

<p>False</p> Signup and view all the answers

Osteoarthritis is a type of chronic arthritis.

<p>True</p> Signup and view all the answers

Rheumatoid arthritis is classified as acute arthritis.

<p>False</p> Signup and view all the answers

Gouty arthritis is a type of chronic arthritis.

<p>True</p> Signup and view all the answers

Arthritis refers to inflammation of one or more joints.

<p>True</p> Signup and view all the answers

Paget's disease of bone is a predisposing factor for osteosarcoma.

<p>True</p> Signup and view all the answers

Ewing's sarcoma is more common in individuals older than 40 years of age.

<p>False</p> Signup and view all the answers

Suppurative arthritis is a type of acute arthritis.

<p>True</p> Signup and view all the answers

Metastatic tumours are characterized by multifocality and predilection for the bone marrow sites in the axial skeleton (vertebrae, pelvis, ribs and ______) and proximal long bones.

<p>cranium</p> Signup and view all the answers

In adults, more than 75% of skeletal metastases originate from cancers of the thyroid, prostate, breast, kidney, and ______.

<p>lung</p> Signup and view all the answers

In children, metastatic disease derives most commonly from neuroblastoma, Wilms tumour, Ewing sarcoma and ______.

<p>rhabdomyosarcoma</p> Signup and view all the answers

Osteosarcoma is one of the commonest malignant tumours of bone which has ______ prognosis.

<p>bad</p> Signup and view all the answers

Osteosarcoma typically occurs at ages between 10-25 years and mainly affects the metaphysis of long bones, particularly around the ______ joint.

<p>knee</p> Signup and view all the answers

Ewing's sarcoma usually arises in the ______ of long bones.

<p>metaphysis</p> Signup and view all the answers

Osteosarcomas are composed of large, hyperchromatic, pleomorphic, mitotically active tumour cells. They can exhibit ______, chondroblastic, or fibroblastic differentiation

<p>osteoblastic</p> Signup and view all the answers

Chondrosarcoma is the second most common malignant matrix-producing bone tumour; after osteosarcoma, it is of better prognosis than ______

<p>osteosarcoma</p> Signup and view all the answers

Ewing's sarcoma is a malignant tumour of uncertain origin, most probably from endothelial, or neurogenic cells in bone marrow, (myelogenic) and it has ______ prognosis

<p>good</p> Signup and view all the answers

Most patients with Chondrosarcoma are older than ______ years

<p>40</p> Signup and view all the answers

Ewing's sarcoma usually arises in the ______ of long bones

<p>diaphysis</p> Signup and view all the answers

Arthritis means inflammation of one or more ______

<p>joints</p> Signup and view all the answers

Suppurative arthritis is a type of ______ arthritis

<p>acute</p> Signup and view all the answers

The majority of skeletal metastases originate from ______ cancers

<p>thyroid, prostate, breast, kidney, and lung</p> Signup and view all the answers

Many bone metastases are ______, and the clinical effects are mainly pain and bone destruction

<p>asymptomatic</p> Signup and view all the answers

Rheumatoid arthritis is a type of ______ arthritis

<p>chronic</p> Signup and view all the answers

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