Human Biology: Gut Health and Appendicitis
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Questions and Answers

What is the name of the inflammation caused by a ruptured appendix?

  • Colitis
  • Diverticulitis
  • Appendicites
  • Peritonitis (correct)
  • Where is pain typically felt when experiencing appendicitis?

  • Lower left quadrant of the abdomen
  • Upper left quadrant of the abdomen
  • Lower right quadrant of the abdomen (correct)
  • Upper right quadrant of the abdomen
  • What is the purpose of the appendix, according to the content?

  • It produces enzymes that help break down food.
  • It plays a crucial role in food digestion.
  • It serves as a reservoir for 'good bacteria' that can repopulate the colon. (correct)
  • It is a vestigial organ with no known function.
  • What is the approximate ratio of gut bacteria to human cells in the body?

    <p>10:1 (D)</p> Signup and view all the answers

    What is the term used to describe a relationship where both organisms benefit?

    <p>Mutualism (B)</p> Signup and view all the answers

    What is the role of the gut microbiome in relation to serotonin?

    <p>It influences the levels of serotonin in the body, which can affect mood. (D)</p> Signup and view all the answers

    What is a key factor that influences the composition of the gut microbiome?

    <p>Diet (A)</p> Signup and view all the answers

    When does the formation of the gut microbiome typically begin?

    <p>At birth (B)</p> Signup and view all the answers

    Which of the following enzymes break down proteins into di- and tri-peptides?

    <p>Pancreatic proteases (A)</p> Signup and view all the answers

    What is the primary function of small intestine peptidases?

    <p>To break down di- and tri-peptides into single amino acids (C)</p> Signup and view all the answers

    What is the primary mechanism of amino acid absorption into the absorptive cells?

    <p>Active transport (D)</p> Signup and view all the answers

    Which of the following is NOT a true statement regarding amino acid absorption?

    <p>Amino acids are passively absorbed into the absorptive cells via diffusion. (C)</p> Signup and view all the answers

    What is the primary fate of absorbed amino acids in the body?

    <p>Incorporation into cell proteins (C)</p> Signup and view all the answers

    How does the body regulate calcium absorption?

    <p>By controlling the production of both parathyroid hormone and vitamin D. (D)</p> Signup and view all the answers

    Which of the following is NOT a function of parathyroid hormone?

    <p>Stimulates the breakdown of bone to release calcium into the bloodstream (A)</p> Signup and view all the answers

    What is the primary mechanism for the absorption of calcium ions?

    <p>Active transport (A)</p> Signup and view all the answers

    What is one potential benefit of a diet for type 2 diabetes management?

    <p>Weight loss (D)</p> Signup and view all the answers

    Which type of foods are suggested to be beneficial for regulating blood glucose levels in people with diabetes?

    <p>Organ meats (D)</p> Signup and view all the answers

    What is a risk associated with dietary changes for type 2 diabetes management?

    <p>Pancreatitis (B)</p> Signup and view all the answers

    What is a common gastrointestinal effect of dietary changes aimed at managing type 2 diabetes?

    <p>GI side effects (C)</p> Signup and view all the answers

    What is one of the functions of GLP-1 receptor agonists in type 2 diabetes treatment?

    <p>Increase insulin production (B)</p> Signup and view all the answers

    Which of the following is NOT a mentioned risk of dietary changes for type 2 diabetes?

    <p>Weight gain (C)</p> Signup and view all the answers

    How does insulin loss or resistance affect blood glucose levels?

    <p>It increases blood glucose levels (B)</p> Signup and view all the answers

    Which of the following diets incorporates a no sugar, no grains approach?

    <p>Atkins diet (B)</p> Signup and view all the answers

    Which monosaccharides are formed from sucrose breakdown?

    <p>Glucose and fructose (A)</p> Signup and view all the answers

    What is the primary function of insulin in relation to glucose?

    <p>Triggers glucose uptake into cells (A)</p> Signup and view all the answers

    What is the process called when nutrients are removed as blood passes through the liver?

    <p>First pass effect (B)</p> Signup and view all the answers

    Which enzyme is responsible for breaking down lactose?

    <p>Lactase (D)</p> Signup and view all the answers

    What happens to excess glucose after it is absorbed?

    <p>It is converted into glycogen (B)</p> Signup and view all the answers

    Which of the following nutrients is glucose primarily used for?

    <p>Energy production (C)</p> Signup and view all the answers

    What role do capillaries in the intestinal villi serve?

    <p>Transport monosaccharides to the liver (D)</p> Signup and view all the answers

    During which phase is glucose uptake triggered by insulin?

    <p>Post-prandial phase (C)</p> Signup and view all the answers

    Which sugar is NOT a product of carbohydrate digestion?

    <p>Sucrose (A)</p> Signup and view all the answers

    What triggers facilitated diffusion for glucose uptake in cells?

    <p>Insulin binding to receptors (C)</p> Signup and view all the answers

    What role do bile salts play in lipid digestion?

    <p>They emulsify lipids, increasing enzyme access. (A)</p> Signup and view all the answers

    Where does lipid digestion primarily occur?

    <p>In the small intestine, after emulsification. (A)</p> Signup and view all the answers

    What is the primary function of lingual lipase in lipid digestion?

    <p>To initiate the digestion of triglycerides. (A)</p> Signup and view all the answers

    What limits the effectiveness of enzymes on lipid molecules?

    <p>The insolubility of lipids affecting enzyme access. (D)</p> Signup and view all the answers

    Which of the following enzymes are involved in the digestion of triglycerides?

    <p>Lipases present in pancreatic juices. (D)</p> Signup and view all the answers

    What is the primary function of amylase in pancreatic juice?

    <p>Digests starch (B)</p> Signup and view all the answers

    Which enzyme is activated by brush border enzymes in the digestive process?

    <p>Trypsin (C)</p> Signup and view all the answers

    What structural feature of the gallbladder facilitates the removal of gallstones?

    <p>Muscular contractions (A)</p> Signup and view all the answers

    Which of the following is NOT one of the functions attributed to pancreatic juice?

    <p>Activate gallstones (C)</p> Signup and view all the answers

    Which digestive enzyme specifically digests triglycerides?

    <p>Lipase (A)</p> Signup and view all the answers

    What process can facilitate the fragmentation of gallstones, besides surgery?

    <p>Oral ingestion of bile acids (A), High energy shock waves (B)</p> Signup and view all the answers

    Which type of enzymes are found on the brush border and are essential for digestion?

    <p>Brush border enzymes (A)</p> Signup and view all the answers

    What is the main role of the pancreas in digestion?

    <p>To produce digestive enzymes (A)</p> Signup and view all the answers

    Flashcards

    Gallbladder Removal Surgery

    A surgical procedure to remove the gallbladder, often due to gallstones.

    Gallstones

    Solid particles formed from bile in the gallbladder, can block bile ducts.

    Pancreas

    An accessory digestive organ that produces digestive enzymes and hormones.

    Pancreatic Juice

    A fluid produced by the pancreas containing digestive enzymes.

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    Amylase

    An enzyme in pancreatic juice that digests starch into sugar.

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    Trypsin

    A protease enzyme activated in the intestine that digests proteins.

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    Lipase

    An enzyme in pancreatic juice that digests triglycerides into fatty acids.

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    Brush Border Enzymes

    Enzymes present on the intestinal lining that activate trypsin and aid digestion.

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    Appendix

    A small pouch in the lower abdomen, thought to store good bacteria.

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    Appendicitis

    Inflammation of the appendix, causing pain in the lower right abdomen.

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    Peritonitis

    Inflammation of the peritoneal cavity, often due to a ruptured appendix.

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    Gut microbiome

    Colonies of bacteria that start forming in the gut at birth.

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    Intestinal microbiota

    Microorganisms in the gut, outweighing human cells by 10 times.

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    Colon's role after diarrhea

    Appendix can help re-colonize the colon with good bacteria post-diarrhea.

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    Influence of diet on gut bacteria

    Diet affects the growth of gut microbial colonies.

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    Serotonin and mental health

    Serotonin levels can be affected by gut bacteria, influencing mood disorders.

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    Triglycerides digestion

    Triglycerides are mainly digested by lingual lipase, accounting for less than 10% of fat digestion.

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    Lingual lipase

    An enzyme that begins the digestion of triglycerides in the mouth with saliva.

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    Emulsification

    The process by which bile salts break down lipids into small droplets for easier digestion.

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    Role of bile salts

    Bile salts enhance lipid digestion by breaking lipids into smaller droplets, improving access for lipases.

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    Sucrase

    An enzyme that breaks down sucrose into glucose and fructose.

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    Monosaccharides

    Simple sugars formed after carbohydrate digestion, like glucose and fructose.

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    Absorptive cells

    Cells in the intestinal villi that absorb nutrients.

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    Hepatic portal system

    Blood vessels that transport absorbed nutrients to the liver.

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    First pass effect

    The removal of nutrients from blood as it passes through the liver.

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    Glycogen

    A storage form of glucose found in the liver and muscles.

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    Insulin

    A hormone that helps glucose enter cells for energy.

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    Facilitated diffusion

    Process of glucose entering cells with the help of insulin.

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    Lactose

    A disaccharide made of glucose and galactose, digested by lactase.

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    Post-absorptive events

    Processes occurring after nutrient absorption, like converting glycogen back to glucose.

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    Insulin and Glucose

    Insulin regulates glucose levels in the blood, especially for diabetes management.

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    Type 2 Diabetes

    A condition where the body becomes resistant to insulin, leading to elevated blood glucose levels.

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    GLP-1 Receptor Agonists

    Medications that help lower blood sugar levels in those with type 2 diabetes.

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    Cholesterol

    A substance in the body that can impact heart health, particularly in diabetes management.

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    Potential Benefits of Diet

    Dietary changes can improve weight loss, insulin control, and cardiovascular risk in diabetes.

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    Potential Downsides

    Dietary changes can lead to GI issues, thyroid tumors, and other serious risks.

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    Organ Meats

    These are nutrient-dense but should be consumed cautiously due to potential health risks.

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    Hypoglycemia

    A condition characterized by abnormally low blood sugar levels, which can be dangerous.

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    Pepsin

    An endopeptidase that cleaves protein bonds in the stomach.

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    Endopeptidases

    Enzymes that cleave internal peptide bonds within proteins.

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    Exopeptidases

    Enzymes that cleave peptide bonds from the ends of protein chains.

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    Pancreatic Proteases

    Enzymes from the pancreas that digest proteins into amino acids.

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    Absorption of Amino Acids

    Amino acids are transported into blood from the intestine's absorptive cells.

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    Brush Border Peptidases

    Enzymes located on the intestinal lining that break down peptides into amino acids.

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    Carrier-Mediated Transport

    Process by which amino acids enter absorptive cells via transport proteins.

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    Study Notes

    Digestive System and Metabolism

    • Readings cover Chapter 18, excluding the section on Neural and Endocrine Regulation of the digestive system.
    • Learning outcomes include functional anatomy of the digestive system, accessory organs, and critical thinking about time-restricted feeding and microbiota.
    • Gastrointestinal gas production averages about 0.5 liters per day, with 14-25 episodes.

    Digestive System Structure

    • Two main organ groups: alimentary canal (continuous hollow tube) and accessory digestive organs.
    • Alimentary canal structures include mouth, pharynx, esophagus, stomach, small intestine, large intestine, and anus.

    Metabolism

    • Digestion involves the breakdown of ingested food and absorption of nutrients into the bloodstream.
    • Waste products are concentrated and removed.
    • Cellular energy production (ATP) and regulation of cellular activities are essential metabolic functions.

    Saliva and Teeth

    • Teeth, specifically incisors, canines, premolars, and molars, are crucial for mastication (chewing).
    • Jaw movement is important for chewing and processing a variety of foods.
    • Teeth are hard structures within the body, with 20 primary and 32 secondary teeth

    Swallowing

    • Deglutition (swallowing) involves the coordination of oral, pharyngeal, and esophageal stages.
    • The mechanism requires 25 pairs of muscles in the mouth, pharynx, larynx, and upper esophagus.

    Esophagus and Stomach

    • The esophagus connects the pharynx to the stomach.
    • Its length is ~25 centimeters.
    • Peristalsis moves food using wave-like muscle contractions.
    • Muscles in the stomach wall mix and mechanically break down food.
    • Circular, longitudinal, and oblique muscles contribute to motility.

    Stomach Secretion

    • Gastric pits are the openings of the gastric glands.
    • Gastric glands contain specialized cells (mucous, chief, and parietal cells) that produce specific secretions.
    • The stomach prevents digestion of itself through a combination of factors.

    Small Intestine

    • Sections include duodenum, jejunum, and ileum.
    • Villi and microvilli increase surface area for nutrient absorption.
    • The intestine contains numerous folds and villi to improve absorption.

    Large Intestine

    • The colon (large intestine) is where water and electrolytes are absorbed from digested material.
    • The colon's bacterial community is important for digestive processes.
    • The appendix, while once thought to lack a function, is now believed to store beneficial bacteria.

    Time Restricted Eating

    • Changing meal schedules can potentially impact body fat.
    • Mice fed restricted hours show a reduction in body fat compared with mice who had access to food at any time.

    Digestive Accessory Organs

    • Liver -Hepatic cells line sinusoids (capillaries). -Kupffer cells (phagocytes) are within sinusoids.
    • The liver has high regenerative abilities and produces bile.
    • Pancreas - produces numerous digestive enzymes.
    • Gallbladder - stores and concentrates bile produced by the liver.
    • The pancreas has both endocrine and exocrine functions.

    Carbohydrates

    • Carbohydrates are categorized into polysaccarides (starch), disaccharides, and monosaccharides (glucose, fructose, galactose).
    • The body primarily ingests carbohydrates as starches.
    • Enzymes, such as lactase, sucrase, and maltase, break down disaccharides to monosaccharides.

    Lipid Digestion

    • Lipid digestion occurs primarily in the small intestine, where bile helps emulsify fats.
    • Pancreatic lipase is the main enzyme for digesting triglycerides into fatty acids and monoglycerides.
    • Fatty acids and monoglycerides are absorbed by the intestinal cells.

    Protein Digestion

    • Proteins are digested into smaller chains of amino acids by enzymes called proteases.
    • The stomach contains pepsin, while the small intestine contains pancreatic and brush border peptidases for digestion.
    • Amino acids are transported into the cells and blood vessels.

    Vitamin Absorption

    • Water-soluble vitamins are absorbed primarily through diffusion in the upper intestines.
    • Fat-soluble vitamins are absorbed with dietary lipids.

    Cholesterol Absorption

    • Cholesterol is a vital component of cell membranes. -It's largely produced in the liver but can be absorbed from the diet.

    Glycemic Index and Insulin

    • The glycemic index (GI) measures how quickly a food raises blood sugar levels.
    • High GI foods can create blood sugar spikes.
    • Insulin helps cells absorb glucose from the bloodstream.
    • Insulin resistance can increase blood sugar levels.

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    Description

    This quiz explores essential concepts related to gut health, including appendicitis and the role of the gut microbiome. Test your knowledge on the function of the appendix, the relationship between gut bacteria and human cells, and the formation of the gut microbiome. Great for students studying human biology or health science!

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