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Questions and Answers
Which hormone treatment in older men is associated with an increase in lean body mass and a decrease in fat mass?
Which hormone treatment in older men is associated with an increase in lean body mass and a decrease in fat mass?
Which hormone treatment in older men is associated with potential risks such as increased cancer risk and soft tissue edema?
Which hormone treatment in older men is associated with potential risks such as increased cancer risk and soft tissue edema?
Which hormone is a food supplement, not a drug, and is readily available in the USA with claims that may be unsubstantiated?
Which hormone is a food supplement, not a drug, and is readily available in the USA with claims that may be unsubstantiated?
Which hormone shows a decline in levels with age, with observational studies suggesting associations with improved quality of life, bone mineral density, and decreased cognitive decline?
Which hormone shows a decline in levels with age, with observational studies suggesting associations with improved quality of life, bone mineral density, and decreased cognitive decline?
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Which hormone treatment has no evidence for beneficial effects on body composition, physical performance, insulin sensitivity, and quality of life in aging individuals?
Which hormone treatment has no evidence for beneficial effects on body composition, physical performance, insulin sensitivity, and quality of life in aging individuals?
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Which hormone treatment may do harm by increasing the risk of osteoporosis and atrial fibrillation, with no evidence for beneficial effect?
Which hormone treatment may do harm by increasing the risk of osteoporosis and atrial fibrillation, with no evidence for beneficial effect?
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Which hormone treatment is associated with an increase in muscle strength with supra-physiological doses, but no convincing functional benefits demonstrated?
Which hormone treatment is associated with an increase in muscle strength with supra-physiological doses, but no convincing functional benefits demonstrated?
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Which hormone is associated with nutritional status and insulin/glucose regulation?
Which hormone is associated with nutritional status and insulin/glucose regulation?
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What is the term used to describe the hormonal changes in menopause and andropause?
What is the term used to describe the hormonal changes in menopause and andropause?
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Which perspective emphasizes the idea of '80 is the new 60' and the use of supplements or hormones to counteract aging?
Which perspective emphasizes the idea of '80 is the new 60' and the use of supplements or hormones to counteract aging?
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Which endocrine disorder is specifically mentioned in the text in relation to diet?
Which endocrine disorder is specifically mentioned in the text in relation to diet?
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Which hormone is referred to as the 'elixir of youth' in the context of aging?
Which hormone is referred to as the 'elixir of youth' in the context of aging?
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Which hormone is associated with the term 'SOMATOPAUSE' in the pharma perspective?
Which hormone is associated with the term 'SOMATOPAUSE' in the pharma perspective?
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What is the term used to describe the nutritional status and insulin/glucose in the context of anorexia nervosa?
What is the term used to describe the nutritional status and insulin/glucose in the context of anorexia nervosa?
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Which of the following is a common phenotype in aging according to the text?
Which of the following is a common phenotype in aging according to the text?
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What happens to insulin and glucose levels with age according to the text?
What happens to insulin and glucose levels with age according to the text?
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How does metabolic syndrome prevalence vary according to the text?
How does metabolic syndrome prevalence vary according to the text?
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What characterizes menopause according to the text?
What characterizes menopause according to the text?
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What is the cautionary approach recommended for hormone replacement therapy (HRT) according to the text?
What is the cautionary approach recommended for hormone replacement therapy (HRT) according to the text?
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What is the association between testosterone levels and libido/erectile dysfunction in older men according to the text?
What is the association between testosterone levels and libido/erectile dysfunction in older men according to the text?
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What is the potential effect of testosterone treatment on bone mineral density according to the text?
What is the potential effect of testosterone treatment on bone mineral density according to the text?
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What is the effect of starvation/anorexia nervosa on insulin, glucose, and leptin?
What is the effect of starvation/anorexia nervosa on insulin, glucose, and leptin?
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Which hormone is a permissive factor for the initiation of puberty and shows a correlation with BMI and body fat?
Which hormone is a permissive factor for the initiation of puberty and shows a correlation with BMI and body fat?
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What is the consequence of starvation/anorexia nervosa on the gonadal axis?
What is the consequence of starvation/anorexia nervosa on the gonadal axis?
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Which hormone deficiency is seen in acute starvation and anorexia nervosa, and is reversible with re-feeding?
Which hormone deficiency is seen in acute starvation and anorexia nervosa, and is reversible with re-feeding?
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What is the effect of starvation/anorexia nervosa on cortisol levels?
What is the effect of starvation/anorexia nervosa on cortisol levels?
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What happens to TSH and T4 levels in the context of starvation/anorexia nervosa?
What happens to TSH and T4 levels in the context of starvation/anorexia nervosa?
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Which hormone is associated with 'GH resistance' and down-regulation of hepatic GH receptor in the context of starvation/anorexia nervosa?
Which hormone is associated with 'GH resistance' and down-regulation of hepatic GH receptor in the context of starvation/anorexia nervosa?
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What is the effect of aging on FSH levels in women according to the text?
What is the effect of aging on FSH levels in women according to the text?
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What is the potential effect of aging on T3 levels according to the text?
What is the potential effect of aging on T3 levels according to the text?
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Which hormone is associated with the term 'SOMATOPAUSE' in the pharma perspective?
Which hormone is associated with the term 'SOMATOPAUSE' in the pharma perspective?
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What is the effect of starvation/anorexia nervosa on insulin, glucose, and leptin?
What is the effect of starvation/anorexia nervosa on insulin, glucose, and leptin?
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Which hormone treatment in older men is associated with an increase in lean body mass and a decrease in fat mass?
Which hormone treatment in older men is associated with an increase in lean body mass and a decrease in fat mass?
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Which hormone deficiency is seen in acute starvation and anorexia nervosa, and is reversible with re-feeding?
Which hormone deficiency is seen in acute starvation and anorexia nervosa, and is reversible with re-feeding?
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What is the effect of aging on FSH levels in women according to the text?
What is the effect of aging on FSH levels in women according to the text?
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What is the term used to describe the hormonal changes in menopause and andropause?
What is the term used to describe the hormonal changes in menopause and andropause?
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What is the prevalence of metabolic syndrome in middle to older age individuals according to the text?
What is the prevalence of metabolic syndrome in middle to older age individuals according to the text?
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What percentage of women experience severe menopausal symptoms lasting 2 to 5 years?
What percentage of women experience severe menopausal symptoms lasting 2 to 5 years?
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What is the average age of menopause according to the text?
What is the average age of menopause according to the text?
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What is the impact of hormone replacement therapy (HRT) on fracture risk and osteoporosis according to the text?
What is the impact of hormone replacement therapy (HRT) on fracture risk and osteoporosis according to the text?
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What is the impact of age on insulin resistance according to the text?
What is the impact of age on insulin resistance according to the text?
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What is the impact of menopause on bone mineral density according to the text?
What is the impact of menopause on bone mineral density according to the text?
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What is the trend in total energy and protein intake with increasing age?
What is the trend in total energy and protein intake with increasing age?
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What is the effect of aging on lean body mass?
What is the effect of aging on lean body mass?
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What is the potential impact of hormone replacement in older individuals?
What is the potential impact of hormone replacement in older individuals?
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What is the common expectation regarding hormonal supplements and aging?
What is the common expectation regarding hormonal supplements and aging?
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What is the cautionary approach recommended for hormone replacement therapy (HRT) in older individuals?
What is the cautionary approach recommended for hormone replacement therapy (HRT) in older individuals?
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What is the impact of age on weight gain according to the lecture?
What is the impact of age on weight gain according to the lecture?
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What is the association between HRT and bone density in women?
What is the association between HRT and bone density in women?
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What is the risk associated with the use of unopposed estrogen in women with a uterus?
What is the risk associated with the use of unopposed estrogen in women with a uterus?
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What is the trend in testosterone prescriptions over the past decades?
What is the trend in testosterone prescriptions over the past decades?
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What is the British Menopause Society's stance on HRT?
What is the British Menopause Society's stance on HRT?
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What is the relationship between testosterone levels and sexual function in men?
What is the relationship between testosterone levels and sexual function in men?
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What is the approach to menopause in terms of hormone replacement therapy?
What is the approach to menopause in terms of hormone replacement therapy?
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What are the potential risks associated with testosterone treatment in older men?
What are the potential risks associated with testosterone treatment in older men?
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Which hormone treatment in older people has evidence suggesting stimulation of testosterone and reduction in fat mass, but lacks convincing evidence for functional benefits?
Which hormone treatment in older people has evidence suggesting stimulation of testosterone and reduction in fat mass, but lacks convincing evidence for functional benefits?
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What is a concern related to growth hormone treatment in older people?
What is a concern related to growth hormone treatment in older people?
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What is a potential effect of testosterone treatment on bone mineral density according to the text?
What is a potential effect of testosterone treatment on bone mineral density according to the text?
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Which treatment is effective for male osteoporosis regardless of androgen status?
Which treatment is effective for male osteoporosis regardless of androgen status?
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What is the impact of testosterone treatment in normal older men on aspects such as physical function, energy, vitality, cognitive function, mood, and quality of life?
What is the impact of testosterone treatment in normal older men on aspects such as physical function, energy, vitality, cognitive function, mood, and quality of life?
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Study Notes
Hormonal Influence on Aging
- Aging and hormonal influence on life expectancy may not equate to increased health expectancy
- Similar phenotypes in aging include hypogonadism, growth hormone deficiency, and high prevalence of fat mass and visceral fat
- Nutritional status and weight change from mid-30s to 50-70 years, with a decrease in lean body mass
- Insulin and glucose levels increase with age, leading to higher insulin resistance and prevalence of metabolic syndrome
- Metabolic syndrome prevalence varies by age and gender, affecting men and women differently
- Menopause, characterized by ovarian failure and decreased estrogen levels, leads to symptoms such as hot flushes and night sweats in women
- Post-menopausal hormone replacement therapy (HRT) has shown mixed benefits and risks, with the risk-to-benefit ratio depending on various factors
- Menopause is a life stage, not a deficiency state, and HRT should be used with caution and clear indication
- Testosterone levels in men gradually decrease with age, with poor association between libido/erectile dysfunction and testosterone levels
- Testosterone treatment in older men may lead to small improvements in sexual function, but potential risks include prostate issues and cardiovascular risks
- Testosterone treatment may have little or no evidence of benefit in physical function, cognitive function, and mood/quality of life
- Testosterone treatment may have a positive effect on bone mineral density if hypogonadal, but the effect on fracture risk is still under study
Older Men, Hormones, and Aging
- Testosterone deficiency in older men can lead to reduced sexual function, osteoporosis, and reduced muscle strength.
- The idea of treating androgen deficiency in older men is not new, with historical examples like Brian Secord's self-experimentation.
- Evidence suggests that testosterone treatment in normal older men may lead to small improvements in sexual function, but it has little impact on other aspects such as physical function, energy, vitality, cognitive function, mood, and quality of life.
- Concerns about potential risks of testosterone treatment include increased risk of benign prostatic hypertrophy, prostate cancer, elevated red blood cell levels, and possible cardiovascular risks.
- Testosterone treatment may improve bone mineral density and body composition, but its impact on fracture risk and functional benefits is uncertain.
- Bisphosphonates are effective for male osteoporosis regardless of androgen status.
- Growth hormone levels decrease with age, leading to lower levels of IGF-1, which is stimulated by growth hormone from the liver.
- Studies sponsored by pharmaceutical companies suggest that growth hormone treatment in older people can stimulate testosterone, increase lean body mass, and reduce fat mass.
- However, the evidence for functional benefits of growth hormone treatment in older people is not convincing, and there are concerns about potential risks and adverse effects.
- The diagnosis and treatment of partial androgen deficiency in older men should be approached with caution, considering potential harm and risks.
- Symptoms of androgen deficiency in older men have a high prevalence, but the clinical picture is not specific, and caution should be exercised in suggesting or avoiding treatment based on symptoms alone.
- The use of growth hormone as a potential anti-aging treatment has been proposed, but evidence for its efficacy and safety in older people is still uncertain.
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Description
Explore the intricate relationship between hormones and aging with this quiz. Delve into topics such as hormonal changes, menopause, testosterone levels, and the impact of hormonal influence on health expectancy. Test your knowledge on the effects of aging on insulin and glucose levels, metabolic syndrome prevalence, and the risks and benefits of hormone replacement therapy.
