Hodgkin's Disease Clinical Presentation

Classical Hodgkin's Disease is composed of two different disease entities: Classical HD and ________.

In Hodgkin's Disease, the bimodal age distribution shows the first peak between the ________ of life.

In Non-Hodgkin's Lymphoma, the Ann Arbor Staging System is commonly used for staging the disease based on the extent of ________ involvement.

Adverse prognostic features in Hodgkin's Disease include presence of ________ symptoms.

Reactive hyperplasia, Chronic lymphadenitis, and Infectious mononucleosis are differential diagnoses of ________ disease.

In Hodgkin's Disease, the male to female ratio is 2:1 in kids, while in adults it is ________.

Nodular Sclerosing Hodgkin Lymphoma is characterized by lacunar cells in nodular sclerosis Hodgkin’s lymphoma and is a type of ________ disease.

In the Ann Arbor Staging System, Stage I involves the involvement of a single lymph node region or a single extralymphatic organ or site (IE), while Stage II involves ________.

Stage III in the Ann Arbor Staging System for Hodgkin's Disease involves the involvement of lymph node regions on both sides of the diaphragm which may be accompanied by involvement of the spleen (IIIS) or by localized involvement of an extralymphatic organ or site (IIIE) or ________.

In the Ann Arbor Staging System, Stage IV is characterized by diffuse or disseminated involvement of one or more extra lymphatic organs or tissues with or without associated lymph node involvement. Stage IV is an example of a stage that involves ________.

B symptoms in Hodgkin's Disease are defined as fever > 38ºC for three consecutive days, drenching night sweats, or unexplained loss of ________ or more of weight the preceding 6 months.

The lymphocyte depletion type of Hodgkin’s lymphoma is characterized by numerous atypical cells present in a densely fibrotic stroma with scanty ________.

Lymphocyte-predominant Hodgkin’s (LPHD), making up ~ 5% of cases A common factor of both HD types is that neoplastic cells constitute only a small minority of the cells in the affected tissue, often corresponding to < 2% of the total tumor. % OF PATIENTS Most commonly involved lymph nodes are the cervical and supraclavicular in 75%. Bone marrow is involved in ___% of patients.

Hodgkin’s Disease/Lymphoma is a fatal disease with ___% of untreated patients dying within 2 to 3 years. With chemotherapy, >80% of patients suffering from HD are cured.

HD nearly always arises and disseminates in lymph nodes. Contiguous spread via the lymphatic chain e.g. involvement of abdominal & thoracic LNs. Hodgkin Disease/Lymphoma “Classic” Hodgkin’s Disease nodular sclerosis mixed cellularity lymphocyte depleted classical lymphocyte rich HRS cells CD30 and CD15 positive. Nodular lymphocyte predominant HRS cells (L&H cells) have B cell markers CD 20 and surface Immunoglobulin Classic Hodgkin Lymphoma (mixed cellularity) Presence of the EBV genome in a case of ___ lymphoma as demonstrated immunohistochemically by the detection of LMP1 antigen.

Hodgkin’s Disease/Lymphoma Clinical Presentation SIGNS & SYMPTOMS Lymphadenopathy Mediastinal mass “B” symptoms Fever, weight loss, night sweats Hepatosplenomegaly % OF PATIENTS 90 60 30 25. Most commonly involved lymph nodes are the cervical and supraclavicular in ___%.

Pathogenesis of HD is still largely unknown. HD nearly always arises and disseminates in lymph nodes. Contiguous spread via the lymphatic chain e.g. involvement of abdominal & thoracic LNs. Hodgkin Disease/Lymphoma “Classic” Hodgkin’s Disease nodular sclerosis mixed cellularity lymphocyte depleted classical lymphocyte rich HRS cells CD30 and CD15 positive. Nodular lymphocyte predominant HRS cells (L&H cells) have B cell markers CD 20 and surface Immunoglobulin Classic Hodgkin Lymphoma (mixed cellularity) Presence of the EBV genome in a case of Hodgkin’s lymphoma as demonstrated immunohistochemically by the detection of ___ antigen.

Most commonly involved lymph nodes are the cervical and supraclavicular in 75%. Bone marrow is involved in 5% of patients. Hodgkin’s Disease/Lymphoma Clinical Presentation SIGNS & SYMPTOMS Lymphadenopathy Mediastinal mass “B” symptoms Fever, weight loss, night sweats Hepatosplenomegaly % OF PATIENTS 90 60 30 25. Hodgkin’s Disease/Lymphoma is a fatal disease with 90% of untreated patients dying within 2 to 3 years. With chemotherapy, >80% of patients suffering from HD are cured.Pathogenesis of HD is still largely unknown. HD nearly always arises and disseminates in lymph nodes Contiguous spread via the lymphatic chain e.g. involvement of abdominal & thoracic LNs Hodgkin Disease/Lymphoma “Classic” Hodgkin’s Disease nodular sclerosis mixed cellularity lymphocyte depleted classical lymphocyte rich HRS cells CD30 and CD15 positive. Nodular lymphocyte predominant HRS cells (L&H cells) have B cell markers CD 20 and surface Immunoglobulin Classic Hodgkin Lymphoma (mixed cellularity) Presence of the ___ genome in a case of Hodgkin’s lymphoma as demonstrated immunohistochemically by the detection of LMP1 antigen.