18 Questions
What are the B symptoms associated with Hodgkin's disease?
Recurrent drenching night sweats, unexplained, persistent, or recurrent fever, unexplained weight loss of more than 10% of body weight
What are the criteria for a 'bulk' mass in the context of Hodgkin's disease?
10 cm nodal mass or mediastinal mass > 1/3 thorax diameter
What are some adverse prognostic features for stages I & II of Hodgkin's disease according to EORTC data?
More than 3 nodal sites, bulky adenopathy, ESR > 50, presence of B symptoms, invasion into critical organs, male age > 40
Which subtype of B cell malignancies should probably not receive XRT alone?
MC or LD subtype
What type of lymphoma is characterized by Progressive B lymphocyte maturation?
Chronic lymphocytic leukemia
What are the two main types of solid masses in the context of lymphoid malignancies?
Hodgkin and Non-Hodgkin lymphomas
What are the 'B' symptoms associated with Hodgkin's Disease/Lymphoma?
Fever, weight loss, night sweats
What percentage of untreated patients with Hodgkin's Disease/Lymphoma are at risk of dying within 2 to 3 years?
90%
Which type of Hodgkin's Disease/Lymphoma is characterized by neoplastic cells constituting only a small minority of the cells in the affected tissue?
Lymphocyte-predominant Hodgkin’s (LPHD)
What are the most commonly involved lymph nodes in Hodgkin's Disease/Lymphoma?
Cervical and supraclavicular
What percentage of patients with Hodgkin's Disease/Lymphoma have bone marrow involvement?
5%
What is the approximate cure rate of patients suffering from Hodgkin's Disease with chemotherapy?
>80%
What are the B symptoms in Hodgkin's disease?
Fever > 38ºC for three consecutive days, drenching night sweats, unexplained loss of 10% or more of weight in the preceding 6 months
Define Stage III in the Ann Arbor Staging System for Hodgkin's Disease.
Involvement of lymph node regions on both sides of the diaphragm, which may be accompanied by involvement of the spleen or by localized involvement of an extralymphatic organ or site or both.
What is the significance of lacunar cells in nodular sclerosis Hodgkin's lymphoma?
Lacunar cells are characteristic of nodular sclerosis subtype of Hodgkin's lymphoma, indicating a specific histological pattern.
Explain the involvement criteria for Stage IV in the Ann Arbor Staging System for Hodgkin's Disease.
Diffuse or disseminated involvement of one or more extra lymphatic organs or tissues with or without associated lymph node involvement.
What is the role of the spleen in Stage IIIS of the Ann Arbor Staging System for Hodgkin's Disease?
In Stage IIIS, involvement of lymph node regions on both sides of the diaphragm is accompanied by spleen involvement.
What are the adverse prognostic features in Hodgkin's lymphoma?
Adverse prognostic features include B symptoms, advanced stage (IV), significant weight loss, and extranodal involvement.
Test your knowledge on the Modified Ann Arbor Staging, B symptoms, and criteria for bulk in Hodgkin Disease/Lymphoma. Learn about adverse prognostic features for stage I & II based on EORTC data.
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