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Questions and Answers
Nodular Sclerosing Hodgkin Lymphoma is characterized by lacunar cells in a densely fibrotic stroma.
Nodular Sclerosing Hodgkin Lymphoma is characterized by lacunar cells in a densely fibrotic stroma.
True
Lymphocyte depletion type of Hodgkin’s lymphoma is characterized by abundant lymphocytes in the affected areas.
Lymphocyte depletion type of Hodgkin’s lymphoma is characterized by abundant lymphocytes in the affected areas.
False
Involvement of two or more lymph node regions on the same side of the diaphragm corresponds to Stage II in the Ann Arbor Staging System for Non-Hodgkin's Lymphoma.
Involvement of two or more lymph node regions on the same side of the diaphragm corresponds to Stage II in the Ann Arbor Staging System for Non-Hodgkin's Lymphoma.
False
Presence of B symptoms such as fever, night sweats, and unexplained weight loss are considered adverse prognostic features in Hodgkin's Disease.
Presence of B symptoms such as fever, night sweats, and unexplained weight loss are considered adverse prognostic features in Hodgkin's Disease.
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Stage IV in the Ann Arbor Staging System indicates localized involvement of an extralymphatic organ or site on both sides of the diaphragm.
Stage IV in the Ann Arbor Staging System indicates localized involvement of an extralymphatic organ or site on both sides of the diaphragm.
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Hodgkin's Disease Stage III may involve lymph node regions on both sides of the diaphragm and may be accompanied by involvement of the spleen.
Hodgkin's Disease Stage III may involve lymph node regions on both sides of the diaphragm and may be accompanied by involvement of the spleen.
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In Hodgkin Disease/ Lymphoma, an adverse prognostic feature for stage I & II (EORTC data) includes ESR below 50.
In Hodgkin Disease/ Lymphoma, an adverse prognostic feature for stage I & II (EORTC data) includes ESR below 50.
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According to the Ann Arbor Staging System, bulk is defined as a nodal mass greater than 5 cm.
According to the Ann Arbor Staging System, bulk is defined as a nodal mass greater than 5 cm.
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Presence of more than 3 nodal sites is considered an adverse prognostic feature for B cell malignancies.
Presence of more than 3 nodal sites is considered an adverse prognostic feature for B cell malignancies.
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B symptoms include recurrent drenching night sweets and unexplained weight gain of more than 10% of body weight during the previous 6 months.
B symptoms include recurrent drenching night sweets and unexplained weight gain of more than 10% of body weight during the previous 6 months.
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Non-Hodgkin's lymphoma is classified under lymphoid solid masses.
Non-Hodgkin's lymphoma is classified under lymphoid solid masses.
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Critical organs invasion is considered an adverse prognostic feature for Hodgkin's Disease.
Critical organs invasion is considered an adverse prognostic feature for Hodgkin's Disease.
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Lymph node involvement is more common in Hodgkin's Disease compared to Non-Hodgkin's Lymphoma.
Lymph node involvement is more common in Hodgkin's Disease compared to Non-Hodgkin's Lymphoma.
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B symptoms in Hodgkin's Disease include fever, weight loss, and night sweats.
B symptoms in Hodgkin's Disease include fever, weight loss, and night sweats.
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In Hodgkin's Disease, neoplastic cells make up the majority of the cells in the affected tissue.
In Hodgkin's Disease, neoplastic cells make up the majority of the cells in the affected tissue.
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The Ann Arbor Staging System is commonly used for staging Non-Hodgkin's Lymphoma.
The Ann Arbor Staging System is commonly used for staging Non-Hodgkin's Lymphoma.
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Lymphocyte-predominant Hodgkin's is the most common type of Hodgkin's Disease.
Lymphocyte-predominant Hodgkin's is the most common type of Hodgkin's Disease.
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Untreated Hodgkin's Disease has a high cure rate of over 80% with chemotherapy.
Untreated Hodgkin's Disease has a high cure rate of over 80% with chemotherapy.
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Study Notes
Hodgkin's Lymphoma
- Nodular Sclerosing Hodgkin Lymphoma features lacunar cells and a densely fibrotic stroma with scanty lymphocytes.
- Lymphocyte depletion type of Hodgkin's lymphoma is characterized by numerous atypical cells in a densely fibrotic stroma with scanty lymphocytes.
Staging and Classification
- Ann Arbor Staging System for Hodgkin's Disease and Non-Hodgkin's Lymphoma has four stages:
- Stage I: Involvement of a single lymph node region or a single extralymphatic organ or site.
- Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm.
- Stage III: Involvement of lymph node regions on both sides of the diaphragm.
- Stage IV: Diffuse or disseminated involvement of one or more extra lymphatic organs or tissues.
- "B" symptoms include fever > 38°C for three consecutive days, drenching night sweats, or unexplained loss of 10% or more of weight in the preceding six months.
Clinical Presentation
- Common symptoms include lymphadenopathy, mediastinal mass, "B" symptoms, and hepatosplenomegaly.
- The most commonly involved lymph nodes are the cervical and supraclavicular in 75% of cases.
- Bone marrow is involved in 5% of patients.
Pathogenesis and Prognosis
- The pathogenesis of HD is still largely unknown.
- HD nearly always arises and disseminates in lymph nodes.
- Without treatment, 90% of patients die within 2-3 years.
- With chemotherapy, >80% of patients are cured.
Subtypes of Hodgkin's Lymphoma
- "Classic" Hodgkin's Disease subtypes include:
- Nodular sclerosis
- Mixed cellularity
- Lymphocyte-depleted
- Lymphocyte-rich
- Nodular lymphocyte-predominant Hodgkin's lymphoma (LPHD) makes up ~5% of cases and has B cell markers CD20 and surface immunoglobulin.
Adverse Prognostic Features
- Adverse prognostic features for stage I & II include:
- More than three nodal sites
- Bulky adenopathy
- ESR > 50
- B symptoms
- Invasion into critical organs
- Male age > 40
- MC or LD subtype
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Description
Test your knowledge on the Modified Ann Arbor Staging criteria for Hodgkin Disease and Lymphoma. This quiz covers topics such as extranodal disease, B symptoms, bulk criteria, adverse prognostic features, and more.
