HIV Life Cycle and Infection Stages

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Questions and Answers

What is the correct order of the seven stages of the HIV life cycle?

  • Fusion, Binding, Reverse Transcription, Replication, Integration, Assembly, Budding
  • Binding, Fusion, Replication, Integration, Assembly, Reverse Transcription, Budding
  • Budding, Assembly, Integration, Reverse Transcription, Binding, Fusion, Replication
  • Binding, Fusion, Reverse Transcription, Integration, Replication, Assembly, Budding (correct)

During which stage of HIV infection are symptoms like headache and sore throat most likely to occur?

  • Acute HIV infection (correct)
  • AIDS
  • Symptomatic HIV infection
  • Chronic HIV infection

What distinguishes the Clinical Latency stage from the Acute HIV Infection stage?

  • High levels of HIV replication
  • The presence of severe symptoms
  • The progression to AIDS
  • Low levels of HIV replication with potential asymptomatic status (correct)

What is the final stage of HIV infection known as?

<p>AIDS (D)</p> Signup and view all the answers

Which symptom is least likely to be associated with Acute HIV Infection?

<p>Weight loss (D)</p> Signup and view all the answers

Which of the following statements about the Clinical Latency stage is true?

<p>Individuals can stay in this stage for several years without treatment. (A)</p> Signup and view all the answers

What role do CD4 cells play in relation to HIV?

<p>HIV uses them to replicate and spread. (B)</p> Signup and view all the answers

What effect does untreated HIV eventually have on the body?

<p>Weakening of the immune system over time (C)</p> Signup and view all the answers

Which of the following statements accurately describes HIV?

<p>HIV is a retrovirus that primarily attacks CD4 T cells. (D)</p> Signup and view all the answers

How is HIV primarily transmitted from an infected individual to others?

<p>Via sexual contact, sharing needles, or from mother to child. (B)</p> Signup and view all the answers

What is the primary characteristic that distinguishes HIV 1 from HIV 2?

<p>HIV 1 progresses to AIDS more rapidly than HIV 2. (C)</p> Signup and view all the answers

What is the origin of HIV infection in humans?

<p>It jumped from chimpanzees to humans through blood contact. (C)</p> Signup and view all the answers

Which of the following is NOT a method of HIV transmission?

<p>Via food contaminated with the virus. (B)</p> Signup and view all the answers

What role do CD4 T cells play in the human body?

<p>They help fight disease and infections. (D)</p> Signup and view all the answers

In what region is HIV 2 predominantly found?

<p>West Africa (C)</p> Signup and view all the answers

What significant change occurs if HIV is not treated?

<p>It can lead to the development of AIDS. (B)</p> Signup and view all the answers

What percentage of the new HIV infections in the US in 2006 were attributed to male-male sexual contact?

<p>53% (B)</p> Signup and view all the answers

How many total new HIV infections were estimated in the US for 2006?

<p>56,300 (C)</p> Signup and view all the answers

Which category had the highest percentage of new HIV infections in 2006?

<p>Male-Male Sexual Contact (A)</p> Signup and view all the answers

What was the prevalence of HIV in the US population in 2006?

<p>0.4% (D)</p> Signup and view all the answers

Which target was NOT set by the SNAP program in Sudan?

<p>Reduce sexual transmission of HIV by 25% by 2012 (A)</p> Signup and view all the answers

What was the estimated number of persons living with HIV in the US in 2006?

<p>1,106,400 (A)</p> Signup and view all the answers

In Sudan, what was the prevalence rate of HIV among those aged 15-49?

<p>0.2-0.3% (A)</p> Signup and view all the answers

What is the primary function of CD4 cells in relation to HIV?

<p>Regulate immune responses (A)</p> Signup and view all the answers

What is the primary function of antigen/antibody tests for HIV?

<p>To detect both antibodies and viral proteins in the blood (A)</p> Signup and view all the answers

Which of the following symptoms are commonly associated with AIDS?

<p>Extreme tiredness and oral thrush (D)</p> Signup and view all the answers

What factor may decrease the risk of HIV transmission?

<p>Condom use during sexual activities (B)</p> Signup and view all the answers

How long can antibody tests typically take to detect HIV after exposure?

<p>23 to 90 days (A)</p> Signup and view all the answers

What is the most accurate statement regarding the types of HIV treatment available?

<p>HIV treatment can involve both pills and shots (B)</p> Signup and view all the answers

Which of the following statements about HIV testing is accurate?

<p>No HIV test can detect the virus immediately after infection (B)</p> Signup and view all the answers

What is a common clinical manifestation of AIDS in relation to lymphatic symptoms?

<p>Prolonged swelling of lymph glands (B)</p> Signup and view all the answers

Which of these factors is a potential risk factor for HIV transmission?

<p>Presence of sexually transmitted diseases (B)</p> Signup and view all the answers

Flashcards

What is HIV?

HIV (Human Immunodeficiency Virus) is a retrovirus that primarily targets the immune system, specifically CD4 T cells.

How is HIV Spread?

HIV is spread through various means: sexual contact, sharing needles, contact with contaminated blood, and mother-to-child transmission during pregnancy, childbirth, or breastfeeding.

What does HIV do to the body?

HIV destroys CD4 T cells, which are crucial white blood cells that help the body fight off infections. Without these cells, the immune system becomes severely weakened, making individuals susceptible to various illnesses.

What are the types of HIV?

HIV-1 is the most common type of HIV, responsible for the majority of infections globally. HIV-2 is primarily found in West Africa and generally progresses more slowly to AIDS.

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Where did HIV originate?

Simian immunodeficiency virus (SIV) is a type of HIV found in chimpanzees. It is believed to have jumped from chimpanzees to humans, likely through contact with infected blood during hunting activities.

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What is HIV incidence?

HIV incidence refers to the number of new HIV infections occurring during a specific period. It indicates the rate at which the virus is spreading.

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What is HIV prevalence?

HIV prevalence refers to the total number of people living with HIV at a specific point in time. It reflects the overall burden of the virus in a population.

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HIV Incidence

The number of newly infected individuals with HIV in a population during a specific period.

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HIV Prevalence

The total number of people living with HIV in a population at a specific point in time.

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HIV (Human Immunodeficiency Virus)

A retrovirus that primarily targets the immune system, specifically CD4 T cells.

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CD4 T lymphocytes

A key component of the immune system that helps fight off infections. HIV specifically destroys these cells, leaving the body vulnerable.

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SNAP (Sudan National AIDS Control Program)

A program created by the Sudan government in 2004 to combat HIV/AIDS. It sets targets to reduce transmission through different paths, like sexual transmission and transmission among injection drug users, as well as preventing mother-to-child transmission.

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Low Epidemic Country

A country with a low prevalence of HIV infection, with an estimated 0.2% to 0.3% prevalence rate among individuals aged 15 to 49.

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Mother-to-Child Transmission of HIV

The transmission of HIV from a pregnant woman to her baby during pregnancy, childbirth, or breastfeeding.

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High-Risk Group

A group of people who are at a higher risk of contracting a disease such as HIV due to their behaviors or circumstances.

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What are CD4 cells and why are they important in HIV?

CD4 cells are a type of white blood cell that are critical in fighting off infections. HIV specifically targets and uses CD4 cells to reproduce.

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What is the HIV life cycle?

The HIV life cycle describes the seven stages HIV goes through to multiply and spread in the body.

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What is Acute HIV Infection?

Acute HIV infection is the first stage, often occurring within 2-6 weeks after infection. It's when the immune system fights back.

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What is Clinical Latency (Chronic HIV Infection)?

Clinical latency, or chronic HIV infection, is the second stage. The virus multiplies at a low level, and people may not feel sick.

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What is AIDS?

AIDS (Acquired Immunodeficiency Syndrome) is the final stage of HIV infection. The immune system weakens significantly, leaving the body vulnerable.

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What are some common symptoms of acute HIV infection?

Headache, fatigue, muscle aches, sore throat, swollen lymph nodes are common symptoms of acute HIV infection. These symptoms are the body's immune response fighting the virus.

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What are the three stages of HIV infection?

HIV infection can be divided into three stages: Acute HIV infection, clinical latency, and AIDS.

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Is there treatment for HIV?

People with HIV can live long and healthy lives with proper treatment. Therapy helps prevent the virus from multiplying and weakening the immune system.

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Antibody test

A type of HIV test that looks for evidence of the virus in a person's blood or saliva. This test measures the body's immune response to HIV.

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Antigen/antibody test

HIV tests that can detect HIV sooner than antibody tests, as they search for both antibodies and a specific protein produced by the virus (p24 antigen) before the body develops antibodies.

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Nucleic acid test (NAT)

A type of HIV test that looks for the virus's genetic material directly in the blood. This test is highly sensitive and can detect HIV very early in the course of infection.

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Viral load

The number of copies of HIV present in a person's blood. A higher viral load indicates a greater risk of transmitting the virus to others.

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Antiretroviral therapy (ART)

A type of HIV treatment that involves taking a combination of antiretroviral drugs, which can slow down the progression of HIV infection and prevent HIV-related illnesses.

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Pre-exposure prophylaxis (PrEP)

A strategy to prevent HIV infection by taking antiretroviral drugs before being exposed to the virus. It is recommended for individuals at high risk of HIV infection.

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HIV Treatment: Injections

A type of HIV treatment that involves injections of medications instead of taking pills. This is an alternative option for those who cannot take oral medications or prefer a different route of administration.

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HIV Treatment: Pills

A type of HIV treatment that involves taking pills prescribed by a health care provider. This is the most common method of HIV treatment.

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Study Notes

Human Immunodeficiency Virus (HIV)

  • HIV is a retrovirus attacking the body's immune system
  • It's an RNA virus with a protective envelope
  • Untreated HIV can progress to AIDS (acquired immunodeficiency syndrome)
  • Two types exist: HIV-1 (more common, widespread, and rapidly progressing) and HIV-2 (primarily in West Africa)

Objectives of the Lecture

  • Students will learn the definition of HIV
  • They will understand the epidemiology of HIV
  • They will be familiar with the clinical picture of HIV
  • They will know the stages of HIV infection
  • They will grasp prevention and control strategies for HIV

What is HIV?

  • HIV targets and destroys CD4 T cells, crucial for immune function
  • CD4 cells are white blood cells essential in fighting infections
  • The virus uses the cells' machinery to replicate and spread throughout the body

How is HIV Caused?

  • HIV transmission occurs through sexual contact
  • It can also be spread through contaminated needles (unclean drug use, or sharing of needles)
  • Transfer via blood contact from infected individuals to others, or through contact with infected blood
  • HIV can even be transmitted from a mother to her child during pregnancy, childbirth, or breastfeeding.

Where did HIV Come From?

  • HIV originated from chimpanzees in Central Africa.
  • The virus likely transferred to humans through contact with chimpanzee blood during hunting for meat
  • HIV has existed in the United States since the mid- to late-1970s and spread across Africa and the world

HIV Incidence and Prevalence

  • HIV incidence: Number of new HIV infections within a particular period
  • HIV prevalence: Number of people living with HIV in a population at a given time

Estimated New HIV Infections (Extended Model)

  • Shows the incidence of new infections.
  • A notable point was reached in 2006.

Estimated Number of AIDS Cases (US 1985-2006)

  • Shows the number of AIDS cases over time
  • High point was reached in the mid 1990s
  • Implementation of the 1993 definition likely attributed to the decline.

Estimated Rates of New HIV Infections (US, 2006, by Race/Ethnicity)

  • Racial disparities in new infections in the USA.

Estimated HIV Incidence (US, 2006, by Transmission Category)

  • Shows the HIV infection incidence in the US in 2006 by category of transmission method
  • Shows percentage of new infections by each transmission method.

Estimated HIV Prevalence (US, 2006)

  • The number of people living with HIV in the U.S. during 2006.

HIV in Sudan (2014 Report)

  • Sudan is surrounded by countries with high HIV prevalence
  • HIV prevalence in the 15-49 age group is low (0.2-0.3%)
  • Around 49,000 adults and 23,000 women of age 15 and over live currently with HIV in the country

HIV Life Cycle

  • HIV attacks CD4 T lymphocytes (cells central to the immune system)
  • HIV uses the host cell's machinery to replicate and multiply
  • This process occurs in seven stages; binding, fusion, reverse transcription, integration, replication, assembly, and budding

What are the Symptoms of HIV?

  • HIV symptoms vary according to infection stages
  • This may include varying symptoms in the three stages

HIV Tests for Screening and Diagnosis

  • HIV antibody tests can detect HIV after a certain period following infection
  • Antigen/antibody tests can detect HIV sooner
  • Different test methods exist (antibody, antigen/antibody, or nucleic acid tests)

HIV Risk and Prevention

  • Factors increasing HIV risk: sexually transmitted infections, acute/late stage HIV, or high viral load
  • Factors decreasing risk: condom use, male circumcision, antiretroviral treatment, and pre-exposure prophylaxis (PrEP)

What is HIV Treatment?

  • Antiretroviral therapy (ART) involves taking medications as prescribed, reducing the viral load of HIV, and helping maintain a good health status.
  • HIV treatment options include pills and, in certain situations, shots. There are several FDA approved pills.

Prevention in general

  • Consistent use of condoms
  • Sterile needles and syringes for all injections
  • Get tested if you are sexually active
  • Take medications where indicated(PrEP) especially during pregnancy to reduce mother-to-child transmission

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