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Questions and Answers
What is the correct order of the seven stages of the HIV life cycle?
What is the correct order of the seven stages of the HIV life cycle?
- Fusion, Binding, Reverse Transcription, Replication, Integration, Assembly, Budding
- Binding, Fusion, Replication, Integration, Assembly, Reverse Transcription, Budding
- Budding, Assembly, Integration, Reverse Transcription, Binding, Fusion, Replication
- Binding, Fusion, Reverse Transcription, Integration, Replication, Assembly, Budding (correct)
During which stage of HIV infection are symptoms like headache and sore throat most likely to occur?
During which stage of HIV infection are symptoms like headache and sore throat most likely to occur?
- Acute HIV infection (correct)
- AIDS
- Symptomatic HIV infection
- Chronic HIV infection
What distinguishes the Clinical Latency stage from the Acute HIV Infection stage?
What distinguishes the Clinical Latency stage from the Acute HIV Infection stage?
- High levels of HIV replication
- The presence of severe symptoms
- The progression to AIDS
- Low levels of HIV replication with potential asymptomatic status (correct)
What is the final stage of HIV infection known as?
What is the final stage of HIV infection known as?
Which symptom is least likely to be associated with Acute HIV Infection?
Which symptom is least likely to be associated with Acute HIV Infection?
Which of the following statements about the Clinical Latency stage is true?
Which of the following statements about the Clinical Latency stage is true?
What role do CD4 cells play in relation to HIV?
What role do CD4 cells play in relation to HIV?
What effect does untreated HIV eventually have on the body?
What effect does untreated HIV eventually have on the body?
Which of the following statements accurately describes HIV?
Which of the following statements accurately describes HIV?
How is HIV primarily transmitted from an infected individual to others?
How is HIV primarily transmitted from an infected individual to others?
What is the primary characteristic that distinguishes HIV 1 from HIV 2?
What is the primary characteristic that distinguishes HIV 1 from HIV 2?
What is the origin of HIV infection in humans?
What is the origin of HIV infection in humans?
Which of the following is NOT a method of HIV transmission?
Which of the following is NOT a method of HIV transmission?
What role do CD4 T cells play in the human body?
What role do CD4 T cells play in the human body?
In what region is HIV 2 predominantly found?
In what region is HIV 2 predominantly found?
What significant change occurs if HIV is not treated?
What significant change occurs if HIV is not treated?
What percentage of the new HIV infections in the US in 2006 were attributed to male-male sexual contact?
What percentage of the new HIV infections in the US in 2006 were attributed to male-male sexual contact?
How many total new HIV infections were estimated in the US for 2006?
How many total new HIV infections were estimated in the US for 2006?
Which category had the highest percentage of new HIV infections in 2006?
Which category had the highest percentage of new HIV infections in 2006?
What was the prevalence of HIV in the US population in 2006?
What was the prevalence of HIV in the US population in 2006?
Which target was NOT set by the SNAP program in Sudan?
Which target was NOT set by the SNAP program in Sudan?
What was the estimated number of persons living with HIV in the US in 2006?
What was the estimated number of persons living with HIV in the US in 2006?
In Sudan, what was the prevalence rate of HIV among those aged 15-49?
In Sudan, what was the prevalence rate of HIV among those aged 15-49?
What is the primary function of CD4 cells in relation to HIV?
What is the primary function of CD4 cells in relation to HIV?
What is the primary function of antigen/antibody tests for HIV?
What is the primary function of antigen/antibody tests for HIV?
Which of the following symptoms are commonly associated with AIDS?
Which of the following symptoms are commonly associated with AIDS?
What factor may decrease the risk of HIV transmission?
What factor may decrease the risk of HIV transmission?
How long can antibody tests typically take to detect HIV after exposure?
How long can antibody tests typically take to detect HIV after exposure?
What is the most accurate statement regarding the types of HIV treatment available?
What is the most accurate statement regarding the types of HIV treatment available?
Which of the following statements about HIV testing is accurate?
Which of the following statements about HIV testing is accurate?
What is a common clinical manifestation of AIDS in relation to lymphatic symptoms?
What is a common clinical manifestation of AIDS in relation to lymphatic symptoms?
Which of these factors is a potential risk factor for HIV transmission?
Which of these factors is a potential risk factor for HIV transmission?
Flashcards
What is HIV?
What is HIV?
HIV (Human Immunodeficiency Virus) is a retrovirus that primarily targets the immune system, specifically CD4 T cells.
How is HIV Spread?
How is HIV Spread?
HIV is spread through various means: sexual contact, sharing needles, contact with contaminated blood, and mother-to-child transmission during pregnancy, childbirth, or breastfeeding.
What does HIV do to the body?
What does HIV do to the body?
HIV destroys CD4 T cells, which are crucial white blood cells that help the body fight off infections. Without these cells, the immune system becomes severely weakened, making individuals susceptible to various illnesses.
What are the types of HIV?
What are the types of HIV?
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Where did HIV originate?
Where did HIV originate?
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What is HIV incidence?
What is HIV incidence?
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What is HIV prevalence?
What is HIV prevalence?
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HIV Incidence
HIV Incidence
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HIV Prevalence
HIV Prevalence
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HIV (Human Immunodeficiency Virus)
HIV (Human Immunodeficiency Virus)
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CD4 T lymphocytes
CD4 T lymphocytes
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SNAP (Sudan National AIDS Control Program)
SNAP (Sudan National AIDS Control Program)
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Low Epidemic Country
Low Epidemic Country
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Mother-to-Child Transmission of HIV
Mother-to-Child Transmission of HIV
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High-Risk Group
High-Risk Group
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What are CD4 cells and why are they important in HIV?
What are CD4 cells and why are they important in HIV?
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What is the HIV life cycle?
What is the HIV life cycle?
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What is Acute HIV Infection?
What is Acute HIV Infection?
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What is Clinical Latency (Chronic HIV Infection)?
What is Clinical Latency (Chronic HIV Infection)?
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What is AIDS?
What is AIDS?
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What are some common symptoms of acute HIV infection?
What are some common symptoms of acute HIV infection?
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What are the three stages of HIV infection?
What are the three stages of HIV infection?
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Is there treatment for HIV?
Is there treatment for HIV?
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Antibody test
Antibody test
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Antigen/antibody test
Antigen/antibody test
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Nucleic acid test (NAT)
Nucleic acid test (NAT)
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Viral load
Viral load
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Antiretroviral therapy (ART)
Antiretroviral therapy (ART)
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Pre-exposure prophylaxis (PrEP)
Pre-exposure prophylaxis (PrEP)
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HIV Treatment: Injections
HIV Treatment: Injections
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HIV Treatment: Pills
HIV Treatment: Pills
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Study Notes
Human Immunodeficiency Virus (HIV)
- HIV is a retrovirus attacking the body's immune system
- It's an RNA virus with a protective envelope
- Untreated HIV can progress to AIDS (acquired immunodeficiency syndrome)
- Two types exist: HIV-1 (more common, widespread, and rapidly progressing) and HIV-2 (primarily in West Africa)
Objectives of the Lecture
- Students will learn the definition of HIV
- They will understand the epidemiology of HIV
- They will be familiar with the clinical picture of HIV
- They will know the stages of HIV infection
- They will grasp prevention and control strategies for HIV
What is HIV?
- HIV targets and destroys CD4 T cells, crucial for immune function
- CD4 cells are white blood cells essential in fighting infections
- The virus uses the cells' machinery to replicate and spread throughout the body
How is HIV Caused?
- HIV transmission occurs through sexual contact
- It can also be spread through contaminated needles (unclean drug use, or sharing of needles)
- Transfer via blood contact from infected individuals to others, or through contact with infected blood
- HIV can even be transmitted from a mother to her child during pregnancy, childbirth, or breastfeeding.
Where did HIV Come From?
- HIV originated from chimpanzees in Central Africa.
- The virus likely transferred to humans through contact with chimpanzee blood during hunting for meat
- HIV has existed in the United States since the mid- to late-1970s and spread across Africa and the world
HIV Incidence and Prevalence
- HIV incidence: Number of new HIV infections within a particular period
- HIV prevalence: Number of people living with HIV in a population at a given time
Estimated New HIV Infections (Extended Model)
- Shows the incidence of new infections.
- A notable point was reached in 2006.
Estimated Number of AIDS Cases (US 1985-2006)
- Shows the number of AIDS cases over time
- High point was reached in the mid 1990s
- Implementation of the 1993 definition likely attributed to the decline.
Estimated Rates of New HIV Infections (US, 2006, by Race/Ethnicity)
- Racial disparities in new infections in the USA.
Estimated HIV Incidence (US, 2006, by Transmission Category)
- Shows the HIV infection incidence in the US in 2006 by category of transmission method
- Shows percentage of new infections by each transmission method.
Estimated HIV Prevalence (US, 2006)
- The number of people living with HIV in the U.S. during 2006.
HIV in Sudan (2014 Report)
- Sudan is surrounded by countries with high HIV prevalence
- HIV prevalence in the 15-49 age group is low (0.2-0.3%)
- Around 49,000 adults and 23,000 women of age 15 and over live currently with HIV in the country
HIV Life Cycle
- HIV attacks CD4 T lymphocytes (cells central to the immune system)
- HIV uses the host cell's machinery to replicate and multiply
- This process occurs in seven stages; binding, fusion, reverse transcription, integration, replication, assembly, and budding
What are the Symptoms of HIV?
- HIV symptoms vary according to infection stages
- This may include varying symptoms in the three stages
HIV Tests for Screening and Diagnosis
- HIV antibody tests can detect HIV after a certain period following infection
- Antigen/antibody tests can detect HIV sooner
- Different test methods exist (antibody, antigen/antibody, or nucleic acid tests)
HIV Risk and Prevention
- Factors increasing HIV risk: sexually transmitted infections, acute/late stage HIV, or high viral load
- Factors decreasing risk: condom use, male circumcision, antiretroviral treatment, and pre-exposure prophylaxis (PrEP)
What is HIV Treatment?
- Antiretroviral therapy (ART) involves taking medications as prescribed, reducing the viral load of HIV, and helping maintain a good health status.
- HIV treatment options include pills and, in certain situations, shots. There are several FDA approved pills.
Prevention in general
- Consistent use of condoms
- Sterile needles and syringes for all injections
- Get tested if you are sexually active
- Take medications where indicated(PrEP) especially during pregnancy to reduce mother-to-child transmission
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