Questions and Answers
Which immune cells are targeted by HIV through the binding of glycoprotein 120?
What is the role of the chemokine receptors CCR5 and CXCR4 in HIV infection?
What additional structure must GP-120 bind to in order to attach to CD4+ T cells?
Which statement about GP-120 is true?
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Which of the following correctly describes the function of GP-120 in HIV infection?
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Study Notes
HIV and Its Targets
- HIV primarily targets the immune system cells: macrophages, dendritic cells, and CD4+ helper T cells.
- Interaction with the immune cells is facilitated by the virus's outer surface glycoprotein, GP-120.
Mechanism of Viral Entry
- GP-120 binds specifically to CD4+ receptors found on dendritic cells, which is crucial for viral attachment.
- For successful entry into macrophages, GP-120 also attaches to the chemokine receptor, CCR5, serving as a secondary binding site.
- In CD4+ T cells, GP-120 requires binding to both the CD4+ receptor and another chemokine receptor, CXCR4, for the virus to enter the cell.
Key Receptors
- CD4+: A primary receptor on immune cells that HIV exploits to gain entry.
- CCR5: A coreceptor that facilitates HIV entry into macrophages.
- CXCR4: Another coreceptor crucial for HIV entry into CD4+ T cells, working alongside CD4+.
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Description
This quiz explores how HIV targets various immune cells, particularly macrophages, dendritic cells, and CD4+ T cells. It focuses on the role of glycoprotein 120 (GP-120) in binding to CD4+ and coreceptors like CCR5 and CXCR4, facilitating viral entry. Test your understanding of these crucial immunological interactions.
