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What is the function of ALG-2 interacting protein X (ALIX) in HIV-1 subtype C p6-Gag?
What is the function of ALG-2 interacting protein X (ALIX) in HIV-1 subtype C p6-Gag?
- Prevents the occurrence of PYRE insertion in HIV-1 C p6
- Enhances the LYPXnL/ALIX pathway in HIV-1 subtype C
- Links HIV-1 Gag to the components of ESCRT-III (correct)
- Inhibits the release defect of PTAP deleted HIV-1
What is the impact of the lack of LYPXnL motif in HIV-1 subtype C?
What is the impact of the lack of LYPXnL motif in HIV-1 subtype C?
- It promotes the occurrence of PYRE insertion in HIV-1 C p6
- It enhances the binding of ALIX to HIV-1 Gag
- It prevents the employment of LYPXnL/ALIX mechanism (correct)
- It increases the release defect of PTAP deleted HIV-1
What is the significance of PYRE insertion in HIV-1 C p6?
What is the significance of PYRE insertion in HIV-1 C p6?
- It prevents the engagement of ALIX via its nucleocapsid
- It enhances the PTAP deletion defect in HIV-1
- It inhibits the binding of ALIX to HIV-1 Gag
- It is predicted to restore the ALIX binding site (correct)
What is the role of ALIX overexpression in HIV-1 construct with subtype C p6 having PTAP deletion and PYRE insertion?
What is the role of ALIX overexpression in HIV-1 construct with subtype C p6 having PTAP deletion and PYRE insertion?
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What is the critical conserved residue in ALIX?
What is the critical conserved residue in ALIX?
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