HIV-1 Subtype C p6-Gag and ALIX Interaction Quiz
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Questions and Answers

What is the function of ALG-2 interacting protein X (ALIX) in HIV-1 subtype C p6-Gag?

  • Prevents the occurrence of PYRE insertion in HIV-1 C p6
  • Enhances the LYPXnL/ALIX pathway in HIV-1 subtype C
  • Links HIV-1 Gag to the components of ESCRT-III (correct)
  • Inhibits the release defect of PTAP deleted HIV-1

    • What is the impact of the lack of LYPXnL motif in HIV-1 subtype C?

  • It promotes the occurrence of PYRE insertion in HIV-1 C p6
  • It enhances the binding of ALIX to HIV-1 Gag
  • It prevents the employment of LYPXnL/ALIX mechanism (correct)
  • It increases the release defect of PTAP deleted HIV-1

    • What is the significance of PYRE insertion in HIV-1 C p6?

  • It prevents the engagement of ALIX via its nucleocapsid
  • It enhances the PTAP deletion defect in HIV-1
  • It inhibits the binding of ALIX to HIV-1 Gag
  • It is predicted to restore the ALIX binding site (correct)

    • What is the role of ALIX overexpression in HIV-1 construct with subtype C p6 having PTAP deletion and PYRE insertion?

    <p>It could respond to ALIX overexpression</p> Signup and view all the answers

    What is the critical conserved residue in ALIX?

    <p>Phenyl alanine (F676)</p> Signup and view all the answers

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