HIV-1 Subtype C p6-Gag and ALIX Interaction Quiz
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Questions and Answers

What is the role of ALIX in HIV-1 subtype C p6-Gag?

  • It links HIV-1 Gag to the components of ESCRT-III (correct)
  • It inhibits the release defect of PTAP deleted HIV-1
  • It enhances the nucleocapsid of HIV-1 subtype C
  • It is responsible for PTAP deletion in HIV-1 subtype C

    • What is the function of PYRE insertion in HIV-1 subtype C p6?

  • To inhibit the release defect of PTAP deleted HIV-1
  • To facilitate PTAP deletion in HIV-1 subtype C
  • To restore the ALIX binding site (correct)
  • To enhance the nucleocapsid of HIV-1 subtype C

    • What does the study show about the response of HIV-1 construct with subtype C p6 having PTAP deletion and PYRE insertion to ALIX overexpression?

  • It showed increased release defect
  • It failed to respond to ALIX overexpression
  • It could respond to ALIX overexpression (correct)
  • It resulted in PTAP restoration

    • What is the impact of the lack of LYPXnL motif in HIV-1 subtype C?

    <p>It prevents the employment of LYPXnL/ALIX mechanism</p> Signup and view all the answers

    What is critical for the response of HIV-1 construct with subtype C p6 having PTAP deletion and PYRE insertion to ALIX overexpression?

    <p>Conserved Phenyl alanine residue (F676) in ALIX</p> Signup and view all the answers

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