FOUNDATION B part 2
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Questions and Answers

Which of the following is not a sentinel cell?

  • Neutrophil (correct)
  • Mast cell
  • Macrophage
  • Dendritic cell

Which of the following activate Mast cells?

  • IgD
  • IgM
  • IgG
  • IgE (correct)

Which of the following are involved in adaptive and innate immune responses?

  • Cytokines (correct)
  • Acute phase proteins
  • Complement proteins
  • Antibodies

Which of the following signs of inflammation does not match its alternative name?

<p>Dolor=swelling (B)</p> Signup and view all the answers

Which of the following regarding MHCs is correct?

<p>β2 microglobulin is not coded for by the same gene that codes for MHC complexes (D)</p> Signup and view all the answers

Which of the following is pentameric?

<p>IgM (B)</p> Signup and view all the answers

Which of the following does not stimulate blocking and neutralisation of infected cells?

<p>IgD (D)</p> Signup and view all the answers

Which of the following complement pathways is initiated by direct contact with pathogens?

<p>Alternative pathway (C)</p> Signup and view all the answers

Which of the following proteins is NOT involved in the formation of the membrane attack complex?

<p>C2 (D)</p> Signup and view all the answers

What is the term for the process by which certain molecules bind to pathogens and enhance their uptake by phagocytic cells?

<p>Opsonisation (C)</p> Signup and view all the answers

What is the primary function of the invariant chain in the antigen presentation process?

<p>To cover the region of the MHC class II that would usually bind to the antigenic peptide (D)</p> Signup and view all the answers

What is the role of the HLA DM protein in the antigen presentation process?

<p>To degrade the invariant chain (C)</p> Signup and view all the answers

What is the name of the vesicle that contains the antigenic peptide and interacts with the MHC class II molecule?

<p>MIIC vesicle (C)</p> Signup and view all the answers

Which proteins are involved in the folding and loading of MHC class I molecules?

<p>Calnexin, ERp57, and tapasin (A)</p> Signup and view all the answers

Through which pathway do proteins captured from outside the cell get presented to CD4+ T cells?

<p>Exogenous pathway (A)</p> Signup and view all the answers

What is the function of the Fab region of an antibody?

<p>It binds to antigens (C)</p> Signup and view all the answers

Which type of immune cell is responsible for killing cells infected with intracellular pathogens?

<p>CD8+ T cells (D)</p> Signup and view all the answers

What is the function of Regulatory T cells in the immune response?

<p>To suppress the activity of other immune cells (B)</p> Signup and view all the answers

What is the difference between T cell and B cell recognition of antigens?

<p>T cells recognise peptides presented by MHC molecules, while B cells recognise epitopes on the external surface of molecules (C)</p> Signup and view all the answers

What is the key difference between innate and adaptive immunity?

<p>Innate immunity provides generalised defence, whereas adaptive immunity provides specific defence (B)</p> Signup and view all the answers

What is the role of sentinels in the immune system?

<p>To recognise and alert the immune system to invading pathogens (A)</p> Signup and view all the answers

Which of the following signs of inflammation is NOT associated with the activation of immune cells?

<p>Loss of function (B)</p> Signup and view all the answers

Which subset of T helper cells is involved in parasitic infections?

<p>Th2 (B)</p> Signup and view all the answers

Which type of infection triggers the activation of Th17 cells?

<p>Extracellular fungal infection (A)</p> Signup and view all the answers

What is the primary function of T-reg cells in the immune response?

<p>To balance the pro-inflammatory response (A)</p> Signup and view all the answers

What is the consequence of the combination of cytokines secreted by different T helper subsets on naive T cells?

<p>Differentiation of naive T cells into different subsets (A)</p> Signup and view all the answers

Which of the following is NOT a function of Th2 cells?

<p>Regulation of MHC expression on macrophages (A)</p> Signup and view all the answers

What is the primary function of Th1 cells in intracellular infections?

<p>To activate macrophages and enhance phagocytosis (D)</p> Signup and view all the answers

Which of the following does sentinel cells release which act on the liver to produce acute phase proteins ?

<p>IL6 (D)</p> Signup and view all the answers

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