FOUNDATION B part 2
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Questions and Answers

Which of the following is not a sentinel cell?

  • Neutrophil (correct)
  • Mast cell
  • Macrophage
  • Dendritic cell
  • Which of the following activate Mast cells?

  • IgD
  • IgM
  • IgG
  • IgE (correct)
  • Which of the following are involved in adaptive and innate immune responses?

  • Cytokines (correct)
  • Acute phase proteins
  • Complement proteins
  • Antibodies
  • Which of the following signs of inflammation does not match its alternative name?

    <p>Dolor=swelling</p> Signup and view all the answers

    Which of the following regarding MHCs is correct?

    <p>β2 microglobulin is not coded for by the same gene that codes for MHC complexes</p> Signup and view all the answers

    Which of the following is pentameric?

    <p>IgM</p> Signup and view all the answers

    Which of the following does not stimulate blocking and neutralisation of infected cells?

    <p>IgD</p> Signup and view all the answers

    Which of the following complement pathways is initiated by direct contact with pathogens?

    <p>Alternative pathway</p> Signup and view all the answers

    Which of the following proteins is NOT involved in the formation of the membrane attack complex?

    <p>C2</p> Signup and view all the answers

    What is the term for the process by which certain molecules bind to pathogens and enhance their uptake by phagocytic cells?

    <p>Opsonisation</p> Signup and view all the answers

    What is the primary function of the invariant chain in the antigen presentation process?

    <p>To cover the region of the MHC class II that would usually bind to the antigenic peptide</p> Signup and view all the answers

    What is the role of the HLA DM protein in the antigen presentation process?

    <p>To degrade the invariant chain</p> Signup and view all the answers

    What is the name of the vesicle that contains the antigenic peptide and interacts with the MHC class II molecule?

    <p>MIIC vesicle</p> Signup and view all the answers

    Which proteins are involved in the folding and loading of MHC class I molecules?

    <p>Calnexin, ERp57, and tapasin</p> Signup and view all the answers

    Through which pathway do proteins captured from outside the cell get presented to CD4+ T cells?

    <p>Exogenous pathway</p> Signup and view all the answers

    What is the function of the Fab region of an antibody?

    <p>It binds to antigens</p> Signup and view all the answers

    Which type of immune cell is responsible for killing cells infected with intracellular pathogens?

    <p>CD8+ T cells</p> Signup and view all the answers

    What is the function of Regulatory T cells in the immune response?

    <p>To suppress the activity of other immune cells</p> Signup and view all the answers

    What is the difference between T cell and B cell recognition of antigens?

    <p>T cells recognise peptides presented by MHC molecules, while B cells recognise epitopes on the external surface of molecules</p> Signup and view all the answers

    What is the key difference between innate and adaptive immunity?

    <p>Innate immunity provides generalised defence, whereas adaptive immunity provides specific defence</p> Signup and view all the answers

    What is the role of sentinels in the immune system?

    <p>To recognise and alert the immune system to invading pathogens</p> Signup and view all the answers

    Which of the following signs of inflammation is NOT associated with the activation of immune cells?

    <p>Loss of function</p> Signup and view all the answers

    Which subset of T helper cells is involved in parasitic infections?

    <p>Th2</p> Signup and view all the answers

    Which type of infection triggers the activation of Th17 cells?

    <p>Extracellular fungal infection</p> Signup and view all the answers

    What is the primary function of T-reg cells in the immune response?

    <p>To balance the pro-inflammatory response</p> Signup and view all the answers

    What is the consequence of the combination of cytokines secreted by different T helper subsets on naive T cells?

    <p>Differentiation of naive T cells into different subsets</p> Signup and view all the answers

    Which of the following is NOT a function of Th2 cells?

    <p>Regulation of MHC expression on macrophages</p> Signup and view all the answers

    What is the primary function of Th1 cells in intracellular infections?

    <p>To activate macrophages and enhance phagocytosis</p> Signup and view all the answers

    Which of the following does sentinel cells release which act on the liver to produce acute phase proteins ?

    <p>IL6</p> Signup and view all the answers

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