Herpes Simplex Virus Infections Overview
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Questions and Answers

What term describes an ulcer that has an epithelial defect covered by a fibrin clot and typically appears yellow-white?

  • Vesicle
  • Erosion
  • Papule
  • Ulcer (correct)
  • Which of the following describes a raised lesion that is greater than 1 cm in diameter?

  • Plaque (correct)
  • Papule
  • Nodule
  • Macule
  • Which viral infection is associated with recurrent oral ulcers and included in the chronic multiple ulcers category?

  • Behçet Disease (correct)
  • Cytomegalovirus
  • Varicella-Zoster Virus
  • Herpes Simplex Virus
  • What type of lesion is characterized by small blisters containing clear fluid and measuring less than 1 cm in diameter?

    <p>Vesicle</p> Signup and view all the answers

    Which condition is characterized by both acute multiple ulcers and vesicular lesions?

    <p>Herpes Simplex Virus Infections</p> Signup and view all the answers

    Which of the following clinical features is NOT typically associated with primary herpetic gingivostomatitis?

    <p>Persistent dry cough</p> Signup and view all the answers

    In which age group is primary herpetic gingivostomatitis most commonly observed?

    <p>2-3 years</p> Signup and view all the answers

    Which histopathological feature is indicative of a viral infection in epithelial cells related to primary herpetic gingivostomatitis?

    <p>Nuclear inclusion bodies</p> Signup and view all the answers

    What is a common fate of primary herpetic gingivostomatitis without severe complications?

    <p>Resolution within 10-14 days</p> Signup and view all the answers

    Which of the following is NOT a characteristic of oral ulcerations in primary herpetic gingivostomatitis?

    <p>Well-defined and scarred</p> Signup and view all the answers

    Study Notes

    Ulcerative, Vesicular and Bullous Lesions

    • Herpes Simplex Virus Infections (HSV) are divided into type 1 and type 2.
    • HSV-1 is mainly associated with oral infections such as primary herpetic gingivostomatitis (PHGS), recurrent intraoral herpes and recurrent herpes labialis.
    • HSV-2 is chiefly associated with genital infections.
    • HSV-1 and HSV-2 can also cause dermatitis, above and below the waist respectively.

    Primary Herpetic Gingivostomatitis

    • Most PHGS infections run a subclinical course
    • PHGS typically occurs in children aged 2-3 years, although it can appear earlier or much later.
    • Maternal IgG can cross the placental barrier and may offer some protection against HSV infections.
    • Typical symptoms include fever, headache, malaise, inflamed gingiva, palpable submandibular and deep cervical lymph nodes.
    • Vesiculobullous lesions are frequently observed.
    • Oral ulcerations are painful, superficial, round and surrounded by an inflammatory halo.
    • They commonly occur on the keratinized and non-keratinized mucosa and the circumoral area.
    • Excessive salivation is a common symptom.
    • PHGS self-resolves in 10-14 days.

    Histopathology of HSV Infections

    • The virus invades and destroys epithelial cells, which leads to intraepithelial vesicle formation.
    • The epithelial lining exhibits multinucleated cells.
    • Nuclear inclusion bodies (Lipschutz bodies) are seen.
    • Ballooning degeneration is observed in infected cells.

    Diagnosis of HSV Infections

    • Diagnosis is based on a combination of clinical history, physical examination and laboratory tests.
    • Prodromal symptoms, gingivitis and ulcerations are important clinical features.
    • Cytological smears can be performed on vesicular fluids to identify the virus.
    • Antibody tests can also help diagnose the infection.

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    Description

    This quiz covers the essential aspects of Herpes Simplex Virus (HSV) infections, including the differences between HSV-1 and HSV-2. Focus on conditions such as primary herpetic gingivostomatitis and the symptoms associated with these infections. Test your understanding of these common viral infections and their clinical manifestations.

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