15 Questions
What are the fundamental changes in cell physiology displayed by all cancers?
Limitless replicative potential (immortality)
How do oncoproteins promote uncontrolled cell proliferation?
By setting up an autocrine loop of cell proliferation
What are oncogenes?
Mutant or overexpressed versions of proto-oncogenes
What is the role of growth factor receptors gene mutations in cancer?
Amplification of epidermal growth factor (EGF) receptor family genes
What is a characteristic of oncoproteins?
Functioning autonomously without normal growth-promoting signals
What is a fundamental change in cell physiology displayed by all cancers?
Sustained angiogenesis
What is the characteristic of RAS mutation in human cancers?
It leads to uncontrolled cellular proliferation
What is the result of the fusion of portions of the ABL tyrosine kinase gene and the BCR protein gene?
Uncontrolled active tyrosine kinase activity
What is the role of MYC gene in cancer?
Activation of the transcription of growth-promoting genes
What is the normal function of cyclin dependent kinase inhibitors (CDKIs)?
Inhibit cell cycle progression
Which gene product applies brakes to cell proliferation?
TP53 gene product p53
What is the function of cyclins and Cyclin-Dependent Kinases (CDKs) complex?
Stimulate cell division
What characteristic is displayed by all cancers?
Limitless replicative potential (immortality)
What is the result of gain-of-function mutations involving CDK4 or cyclin-D?
Cause uncontrolled cell cycle progression and cancers
What is the role of BCR-ABL kinase inhibitor (imatinib mesylate) in treating chronic myeloid leukemia (CML)?
Inhibits uncontrolled tyrosine kinase activity
This quiz covers topics such as HER2 blocking with anti-HER2 antibodies in target therapy, chemotherapy, and mutations in genes encoding signaling molecules like RAS and ABL. It also discusses the implications of RAS mutations in human cancers and its role in cellular proliferation.
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