Podcast
Questions and Answers
What are the fundamental changes in cell physiology displayed by all cancers?
What are the fundamental changes in cell physiology displayed by all cancers?
- Increased sensitivity to growth-inhibitory signals
- Altered cellular metabolism
- Evasion of apoptosis
- Limitless replicative potential (immortality) (correct)
How do oncoproteins promote uncontrolled cell proliferation?
How do oncoproteins promote uncontrolled cell proliferation?
- By increasing sensitivity to growth-inhibitory signals
- By reducing the expression of growth factors and their receptors
- By promoting apoptosis
- By setting up an autocrine loop of cell proliferation (correct)
What are oncogenes?
What are oncogenes?
- Receptors for growth-inhibitory signals
- Mutant or overexpressed versions of proto-oncogenes (correct)
- Normal cellular genes promoting cell proliferation
- Genes responsible for apoptosis
What is the role of growth factor receptors gene mutations in cancer?
What is the role of growth factor receptors gene mutations in cancer?
What is a characteristic of oncoproteins?
What is a characteristic of oncoproteins?
What is a fundamental change in cell physiology displayed by all cancers?
What is a fundamental change in cell physiology displayed by all cancers?
What is the characteristic of RAS mutation in human cancers?
What is the characteristic of RAS mutation in human cancers?
What is the result of the fusion of portions of the ABL tyrosine kinase gene and the BCR protein gene?
What is the result of the fusion of portions of the ABL tyrosine kinase gene and the BCR protein gene?
What is the role of MYC gene in cancer?
What is the role of MYC gene in cancer?
What is the normal function of cyclin dependent kinase inhibitors (CDKIs)?
What is the normal function of cyclin dependent kinase inhibitors (CDKIs)?
Which gene product applies brakes to cell proliferation?
Which gene product applies brakes to cell proliferation?
What is the function of cyclins and Cyclin-Dependent Kinases (CDKs) complex?
What is the function of cyclins and Cyclin-Dependent Kinases (CDKs) complex?
What characteristic is displayed by all cancers?
What characteristic is displayed by all cancers?
What is the result of gain-of-function mutations involving CDK4 or cyclin-D?
What is the result of gain-of-function mutations involving CDK4 or cyclin-D?
What is the role of BCR-ABL kinase inhibitor (imatinib mesylate) in treating chronic myeloid leukemia (CML)?
What is the role of BCR-ABL kinase inhibitor (imatinib mesylate) in treating chronic myeloid leukemia (CML)?
