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HER2 and EGFR Kinase in Cancer
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HER2 and EGFR Kinase in Cancer

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Questions and Answers

What is the main implication of HER2 overexpression in cancer?

  • Increased risk of skin cancer
  • Reduced risk of brain cancer
  • Common in pancreatic and prostate cancers
  • Frequent occurrence in breast, ovarian, and lung cancers (correct)

    • How were the peptidomimetics designed to inhibit HER2-mediated signaling?

  • By blocking HER2 with antibodies only
  • By targeting cell growth indirectly
  • By analyzing the crystal structure of HER2-herceptin complex (correct)
  • By inhibiting EGFR kinase activity

    • What method was used to investigate the chemical diversity of the designed compounds?

  • In silico screening method (correct)
  • In vitro cell culture studies
  • In vivo animal trials
  • Chemical extraction and analysis

    • What do the IC50 values of 0.396 μM and 0.143 μM against SKBR-3 cell lines indicate?

    <p>High antiproliferative activity against breast cancer cell lines</p> Signup and view all the answers

    What was the purpose of using Autodock software in the study?

    <p>To dock analogs of HERP5 and HERP7 with HER2 protein</p> Signup and view all the answers

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