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Questions and Answers
What is the main implication of HER2 overexpression in cancer?
What is the main implication of HER2 overexpression in cancer?
- Increased risk of skin cancer
- Reduced risk of brain cancer
- Common in pancreatic and prostate cancers
- Frequent occurrence in breast, ovarian, and lung cancers (correct)
How were the peptidomimetics designed to inhibit HER2-mediated signaling?
How were the peptidomimetics designed to inhibit HER2-mediated signaling?
- By blocking HER2 with antibodies only
- By targeting cell growth indirectly
- By analyzing the crystal structure of HER2-herceptin complex (correct)
- By inhibiting EGFR kinase activity
What method was used to investigate the chemical diversity of the designed compounds?
What method was used to investigate the chemical diversity of the designed compounds?
- In silico screening method (correct)
- In vitro cell culture studies
- In vivo animal trials
- Chemical extraction and analysis
What do the IC50 values of 0.396 μM and 0.143 μM against SKBR-3 cell lines indicate?
What do the IC50 values of 0.396 μM and 0.143 μM against SKBR-3 cell lines indicate?
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What was the purpose of using Autodock software in the study?
What was the purpose of using Autodock software in the study?
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