Podcast
Play an AI-generated podcast conversation about this lesson
Questions and Answers
What is the main implication of HER2 overexpression in cancer?
What is the main implication of HER2 overexpression in cancer?
- Increased risk of skin cancer
- Reduced risk of brain cancer
- Common in pancreatic and prostate cancers
- Frequent occurrence in breast, ovarian, and lung cancers (correct)
How were the peptidomimetics designed to inhibit HER2-mediated signaling?
How were the peptidomimetics designed to inhibit HER2-mediated signaling?
- By blocking HER2 with antibodies only
- By targeting cell growth indirectly
- By analyzing the crystal structure of HER2-herceptin complex (correct)
- By inhibiting EGFR kinase activity
What method was used to investigate the chemical diversity of the designed compounds?
What method was used to investigate the chemical diversity of the designed compounds?
- In silico screening method (correct)
- In vitro cell culture studies
- In vivo animal trials
- Chemical extraction and analysis
What do the IC50 values of 0.396 μM and 0.143 μM against SKBR-3 cell lines indicate?
What do the IC50 values of 0.396 μM and 0.143 μM against SKBR-3 cell lines indicate?
Signup and view all the answers
What was the purpose of using Autodock software in the study?
What was the purpose of using Autodock software in the study?
Signup and view all the answers
Flashcards are hidden until you start studying
