Podcast
Questions and Answers
What is the main cause of sickle cell anemia?
What is the main cause of sickle cell anemia?
- Increased production of abnormal hemoglobin chains
- Single substitution of valine for glutamic acid in hemoglobin chains (correct)
- Complete absence of hemoglobin chains
- Decreased production of normal hemoglobin chains
What is the difference between hemoglobinopathies and thalassemias?
What is the difference between hemoglobinopathies and thalassemias?
- Hemoglobinopathies and thalassemias both result in normal hemoglobin chains
- Hemoglobinopathies result in decreased production of normal hemoglobin chains, while thalassemias result in abnormal hemoglobin chains
- Hemoglobinopathies result in abnormal hemoglobin chains, while thalassemias result in decreased production of normal hemoglobin chains (correct)
- Hemoglobinopathies and thalassemias are the same thing
What happens to red blood cells in sickle cell anemia?
What happens to red blood cells in sickle cell anemia?
- They become more deformable
- They lose their deformability and hemolyze easily (correct)
- They become more resistant to oxygen
- They become larger in size
Flashcards
Sickle Cell Anemia Cause
Sickle Cell Anemia Cause
A single substitution of valine for glutamic acid in hemoglobin chains.
Hemoglobinopathy vs. Thalassemia
Hemoglobinopathy vs. Thalassemia
Hemoglobinopathies are abnormal hemoglobin chains, while thalassemias result from reduced normal hemoglobin chain production.
Sickle Cell Red Blood Cells
Sickle Cell Red Blood Cells
Red blood cells lose shape and elasticity, leading to easy breakdown.
Hemoglobin Defect
Hemoglobin Defect
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Hemoglobinopathies
Hemoglobinopathies
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Thalassemia
Thalassemia
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Hemoglobin Synthesis
Hemoglobin Synthesis
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Red Blood Cell Deformability
Red Blood Cell Deformability
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Hemolysis
Hemolysis
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Valine Substitution
Valine Substitution
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Study Notes
Sickle Cell Anemia
- Sickle cell anemia is caused by a mutation in the HBB gene that codes for hemoglobin subunit beta, leading to the production of abnormal hemoglobin (HbS).
Hemoglobinopathies and Thalassemias
- Hemoglobinopathies, such as sickle cell anemia, are inherited disorders caused by mutations in the genes that code for hemoglobin subunits, resulting in abnormal hemoglobin production.
- Thalassemias, on the other hand, are inherited disorders caused by mutations in the genes that regulate hemoglobin production, leading to a deficiency in one or more hemoglobin subunits.
Red Blood Cells in Sickle Cell Anemia
- In sickle cell anemia, red blood cells contort into a sickle shape due to the abnormal hemoglobin (HbS), leading to a reduced lifespan of only 10-20 days (normal lifespan is 120 days).
- Sickled red blood cells are prone to clotting and can block small blood vessels, causing pain, infections, and organ damage.
- The abnormal shape of sickled red blood cells also reduces their ability to carry oxygen, leading to anemia and fatigue.
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Description
Test your knowledge on hemoglobinopathies and related disorders with this informative quiz! Learn about the abnormal globin polypeptide chains and thalassemias that can cause decreased or absent production of hemoglobin. Discover the widespread mutant genes that cause abnormal hemoglobins and become an expert on this important medical topic.
