Podcast
Questions and Answers
Which of the following inclusions is specifically associated with Glucose-6-Phosphate Dehydrogenase deficiency?
Which of the following inclusions is specifically associated with Glucose-6-Phosphate Dehydrogenase deficiency?
What is the shape and staining characteristic of Cabot Rings?
What is the shape and staining characteristic of Cabot Rings?
Which stain would you use to observe Hb H inclusion bodies?
Which stain would you use to observe Hb H inclusion bodies?
Which diseases are Howell-Jolly Bodies most commonly associated with?
Which diseases are Howell-Jolly Bodies most commonly associated with?
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Which hemoglobin variant is related to abnormal hemoglobin composed of 4 beta globin chains?
Which hemoglobin variant is related to abnormal hemoglobin composed of 4 beta globin chains?
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Study Notes
Howell-Jolly Bodies
- Appear singly in a cell
- Usually round, less than 1 µm in diameter
- Blue to purple in color
- Remnants of nuclear chromatin (DNA)
- Demonstrated by Wright stain
- Associated with megaloblastic anemias, after splenectomy, and thalassemia
Cabot Rings
- Described as threadlike structures
- Appear as purple-blue loops or rings
- Mitotic spindle remnants
- Detected using Wright stain
- Associated with megaloblastic anemias, refractory anemia, and lead poisoning
Heinz Bodies
- Eccentrically located along the inner RBC membrane
- Appear large, round, and blue to purple
- Denatured and precipitated hemoglobin
- Not demonstrated by Wright stain; may dissolve in stain
- Can be mistaken for other inclusions
- Detected with supravital stains (e.g., BCB, NMB, crystal violet, methyl violet)
Hb H Inclusion Bodies
- Small, multiple, and evenly distributed throughout
- Precipitated Hb H (abnormal Hb composed of 4 beta globin chains/denatured beta-globin chains)
- Detected with supravital stains (e.g., NMB, BCP, Oil red O, methyl violet)
- Associated with Hb H disease (a subtype of alpha thalassemia)
Unstable Hemoglobin Variants
- Examples: Hb Köln, Hb Casper/Southampton, Hb Genova, Hb Gun Hill, Hb M-Saskatoon, Hb Bristol, Hb Torino, Hb Seattle
- Associated with unstable hemoglobin disease (congenital Heinz body hemolytic anemia)
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
- Favism (sensitivity to fava beans), unusual
- Occurs mainly in people of Mediterranean origin and in Chinese
- May result in severe hemolytic episode(s)
- Associated with drug-induced hemolytic anemia
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Description
Test your knowledge on various blood cell inclusions such as Howell-Jolly bodies, Cabot rings, Heinz bodies, and Hb H inclusion bodies. This quiz covers their appearance, staining methods, and associations with different anemias and conditions. It's crucial for students in hematology and related fields.
