Podcast
Questions and Answers
Which of the following inclusions is specifically associated with Glucose-6-Phosphate Dehydrogenase deficiency?
Which of the following inclusions is specifically associated with Glucose-6-Phosphate Dehydrogenase deficiency?
- Howell-Jolly Bodies
- Heinz Bodies (correct)
- Cabot Rings
- Hb H Inclusion Bodies
What is the shape and staining characteristic of Cabot Rings?
What is the shape and staining characteristic of Cabot Rings?
- Round and red with Wright stain
- Small, multiple blue-red inclusions
- Threadlike purple-blue loops or rings (correct)
- Irregular, colorless structures
Which stain would you use to observe Hb H inclusion bodies?
Which stain would you use to observe Hb H inclusion bodies?
- Papanicolaou stain
- Wright stain
- Supravital stain (correct)
- Gram stain
Which diseases are Howell-Jolly Bodies most commonly associated with?
Which diseases are Howell-Jolly Bodies most commonly associated with?
Which hemoglobin variant is related to abnormal hemoglobin composed of 4 beta globin chains?
Which hemoglobin variant is related to abnormal hemoglobin composed of 4 beta globin chains?
Flashcards
Howell-Jolly bodies
Howell-Jolly bodies
Small, round, blue to purple inclusion bodies in RBCs; typically found after splenectomy or in megaloblastic anemias.
Cabot rings
Cabot rings
Threadlike, purplish-blue loops or rings within red blood cells; often associated with megaloblastic anemias or certain types of anemia.
Heinz bodies
Heinz bodies
Small, round, blue inclusions in red blood cells; visible using supravital stains, not Wright stain. Usually associated with G6PD deficiency, some drug-induced anemias, and unstable hemoglobin disease.
Hb H inclusion bodies
Hb H inclusion bodies
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Mittic spindle remnants
Mittic spindle remnants
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Precipitated Hb H
Precipitated Hb H
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Hb Variants
Hb Variants
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Wright stain
Wright stain
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Study Notes
Howell-Jolly Bodies
- Appear singly in a cell
- Usually round, less than 1 µm in diameter
- Blue to purple in color
- Remnants of nuclear chromatin (DNA)
- Demonstrated by Wright stain
- Associated with megaloblastic anemias, after splenectomy, and thalassemia
Cabot Rings
- Described as threadlike structures
- Appear as purple-blue loops or rings
- Mitotic spindle remnants
- Detected using Wright stain
- Associated with megaloblastic anemias, refractory anemia, and lead poisoning
Heinz Bodies
- Eccentrically located along the inner RBC membrane
- Appear large, round, and blue to purple
- Denatured and precipitated hemoglobin
- Not demonstrated by Wright stain; may dissolve in stain
- Can be mistaken for other inclusions
- Detected with supravital stains (e.g., BCB, NMB, crystal violet, methyl violet)
Hb H Inclusion Bodies
- Small, multiple, and evenly distributed throughout
- Precipitated Hb H (abnormal Hb composed of 4 beta globin chains/denatured beta-globin chains)
- Detected with supravital stains (e.g., NMB, BCP, Oil red O, methyl violet)
- Associated with Hb H disease (a subtype of alpha thalassemia)
Unstable Hemoglobin Variants
- Examples: Hb Köln, Hb Casper/Southampton, Hb Genova, Hb Gun Hill, Hb M-Saskatoon, Hb Bristol, Hb Torino, Hb Seattle
- Associated with unstable hemoglobin disease (congenital Heinz body hemolytic anemia)
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
- Favism (sensitivity to fava beans), unusual
- Occurs mainly in people of Mediterranean origin and in Chinese
- May result in severe hemolytic episode(s)
- Associated with drug-induced hemolytic anemia
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Description
Test your knowledge on various blood cell inclusions such as Howell-Jolly bodies, Cabot rings, Heinz bodies, and Hb H inclusion bodies. This quiz covers their appearance, staining methods, and associations with different anemias and conditions. It's crucial for students in hematology and related fields.
