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Questions and Answers
What type of RBC inclusion resembles a semicircular defect and indicates G-6-PD deficiency?
What type of RBC inclusion resembles a semicircular defect and indicates G-6-PD deficiency?
Which RBC inclusion is characterized by an irregular distribution of dark blue to purple granules, indicating aggregated RNA?
Which RBC inclusion is characterized by an irregular distribution of dark blue to purple granules, indicating aggregated RNA?
Which of the following conditions is associated with Biscuit Cells?
Which of the following conditions is associated with Biscuit Cells?
What type of RBC inclusion is likely seen in malaria, characterized by a pale-pink staining ghost of a red blood cell?
What type of RBC inclusion is likely seen in malaria, characterized by a pale-pink staining ghost of a red blood cell?
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What type of basal stippling can be seen in polychromatophilia and megaloblastic anemia?
What type of basal stippling can be seen in polychromatophilia and megaloblastic anemia?
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What distinct staining characteristic does Siderotic Granules demonstrate?
What distinct staining characteristic does Siderotic Granules demonstrate?
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Which RBC inclusion shows a bipolar distribution of hemoglobin and is associated with sickle cell anemia?
Which RBC inclusion shows a bipolar distribution of hemoglobin and is associated with sickle cell anemia?
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What is a common observation for both fine and coarse forms of Basophilic Stippling?
What is a common observation for both fine and coarse forms of Basophilic Stippling?
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Study Notes
Red Blood Cell (RBC) Inclusions
- Bite Cells (Degmacytes): Demonstrate a semicircular defect, resembling a bite mark. Associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- Biscuit Cells: Folded red blood cells. Associated with hemoglobin SC disease.
- Bronze Elliptocytes: Have bipolar or central distribution of hemoglobin. Associated with sickle cell anemia.
- Semilunar Bodies: As large as leukocytes, pale-pink staining ghosts of red blood cells remaining after membrane release. Common in conditions causing hemolysis.
- Basophilic Stippling (Punctate Basophilia): Irregular, dark blue to purple granules evenly distributed within red blood cells. Associated with aggregated RNA. Conditions include lead poisoning, arsenic poisoning, and pyrimidine-5'-nucleotidase deficiency. Also associated with anemias with impaired hemoglobin synthesis (thalassemia), refractory anemia, and alcoholism.
- Siderotic Granules (Pappenheimer bodies): Dark blue, irregular granules in red blood cells. Intra-erythrocytic collections of iron, visualized with Prussian blue staining. Associated with impaired hemoglobin synthesis.
- Basophilic Stippling: Two forms:
- Fine stippling: Often seen with polychromatophilia, plumbism, and megaloblastic anemia.
- Coarse stippling: Related to impaired hemoglobin synthesis, plumbism, and megaloblastic anemia.
Additional Information
- Sideroblastic Anemias: Characterized by a dimorphic peripheral blood picture (presence of both normocytic and hypochromic red blood cells).
- Thalassemia: A condition associated with presence of dimorphic blood cells (presence of both normochromic and hypochromic red blood cells)
- Hemochromatosis/Hemosiderosis: Associated with iron overload.
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Description
Test your knowledge on various red blood cell inclusions and their associated conditions. This quiz covers bite cells, biscuit cells, bronze elliptocytes, and more, detailing their appearances and links to diseases. Perfect for students and professionals in hematology and medical studies.
