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Questions and Answers
HUMAN´s hematology controls can be stored at room temperature.
HUMAN´s hematology controls can be stored at room temperature.
False
Expired hematology control materials can lead to accurate results.
Expired hematology control materials can lead to accurate results.
False
Overheating of hematology control materials can cause denaturation of proteins.
Overheating of hematology control materials can cause denaturation of proteins.
True
Hematology analyzers can be used with instruments from other manufacturers.
Hematology analyzers can be used with instruments from other manufacturers.
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Hematology control materials require gentle mixing before measurement.
Hematology control materials require gentle mixing before measurement.
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Overheating of hematology control materials can lead to increased turbidimetry of the sample.
Overheating of hematology control materials can lead to increased turbidimetry of the sample.
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Hematology control materials can be transported at room temperature.
Hematology control materials can be transported at room temperature.
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Hematology control materials can be used without proper preparation and homogenization.
Hematology control materials can be used without proper preparation and homogenization.
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The control material is stabilized to prolong its shelf life.
The control material is stabilized to prolong its shelf life.
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The shelf life of hematology control material is unlimited.
The shelf life of hematology control material is unlimited.
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Hematology control materials can be used with any analyzer and reagent composition.
Hematology control materials can be used with any analyzer and reagent composition.
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The target values of hematology control materials apply to any setting.
The target values of hematology control materials apply to any setting.
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Red blood cells have a longer lifespan in vivo than platelets.
Red blood cells have a longer lifespan in vivo than platelets.
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Poor mixing of the control material always causes imprecision.
Poor mixing of the control material always causes imprecision.
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Hematology control materials can be preserved indefinitely using refrigeration storage.
Hematology control materials can be preserved indefinitely using refrigeration storage.
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Hematology analyzers can provide accurate results with any control material.
Hematology analyzers can provide accurate results with any control material.
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Hematology controls are used to assess the accuracy of hematology analyzers.
Hematology controls are used to assess the accuracy of hematology analyzers.
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Instrument manufacturers usually supply hematology controls with five levels designed to closely resemble patient samples.
Instrument manufacturers usually supply hematology controls with five levels designed to closely resemble patient samples.
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Quality control in hematology is important to ensure the consistent reliability of sample results.
Quality control in hematology is important to ensure the consistent reliability of sample results.
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The main purpose of internal QC is to detect errors that occur due to failure of the system.
The main purpose of internal QC is to detect errors that occur due to failure of the system.
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In hematology, accuracy refers to the ability to achieve the same result over and over again.
In hematology, accuracy refers to the ability to achieve the same result over and over again.
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Daily measurement of quality control samples is obligatory for intra-instrument quality control.
Daily measurement of quality control samples is obligatory for intra-instrument quality control.
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Hematology controls cover only a limited number of blood parameters.
Hematology controls cover only a limited number of blood parameters.
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Quality control in hematology is only performed to comply with regulatory requirements.
Quality control in hematology is only performed to comply with regulatory requirements.
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Study Notes
Hematology Controls and Quality Control
- Hematology controls are designed to operate with specific analyzers and cannot be used with instruments from other manufacturers due to differences in operation and reagent composition.
Storage and Handling of Hematology Control Material
- Hematology controls require storage at 2-8°C to ensure stability and proper performance.
- During transportation, a constant low temperature must be maintained using Styrofoam boxes and cold packs.
- Expired materials or vials with too little remaining volume can lead to erroneous results.
- Controls require accurate preparation before measurement, including homogenization of blood cells and bringing the material to room temperature.
Overheating – Possible Error Source
- Exposure to temperatures at or above 20°C for prolonged periods can affect control product performance, leading to elevated mean cell volume, red cell fragments, and hemolysis.
- Overheating can also cause denaturation of proteins, which may be counted as platelets, and impaired measurement of hemoglobin.
Accurate but Not Precise (Imprecision)
- Imprecision occurs when measurement values vary a lot between single measurements, despite the mean value being correct.
- Poor mixing of control material can cause imprecision.
Special Characteristics of Hematology Controls
- Hematology controls use stabilized but intact cells from human and mammalian blood.
- Due to the limited lifespan of intact cells, the shelf life of controls is limited.
- Stabilization can prolong the shelf life, but it must be balanced against maintaining cell properties and responsiveness to lysis reagents.
Hematology Controls and Quality Control
- Hematology controls help assess the precision of hematology analyzers, ensuring valid patient results and meeting accreditation requirements.
- Daily measurement of quality control samples is obligatory for intra-instrument quality control.
- Hematology controls cover multiple blood parameters, including erythrocytes, platelets, granulocytes, lymphocytes, monocytes, hematocrit, and hemoglobin.
Importance of Quality Control in Hematology
- Quality control should be performed routinely to ensure consistent reliability of sample results.
- Each laboratory should establish its own QC program complying with accreditation guidelines.
Purposes of Internal Quality Control
- Monitoring of the analytical process.
- Detection of errors due to system failure, adverse environmental conditions, or operator performance.
- Monitoring of long-term test performance.
- Providing proof of adequate long-term quality level and complying with regulatory requirements.
Accuracy and Precision in Hematology Controls
- Accuracy refers to the ability to achieve the right result.
- Precision refers to the ability to achieve the same result over and over again.
- The main goal of QC is to control accuracy and precision of measurements.
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Description
Quiz about the importance of proper storage and handling of hematology control materials and their compatibility with different analyzer systems. Learn how to ensure accurate QC results in hematology.
