Podcast
Questions and Answers
What is the primary mechanism thought to be responsible for Heparin-induced thrombocytopenia (HIT)?
What is the primary mechanism thought to be responsible for Heparin-induced thrombocytopenia (HIT)?
- Catastrophic activation of the coagulation pathway
- Excessive pooling of platelets in an enlarged spleen
- Formation of a microangiopathic haemolytic anaemia
- Activation of platelets and endothelial cells by immune complexes (correct)
Which condition is caused by an autoantibody to a protease enzyme responsible for cleaving von Willebrand factor?
Which condition is caused by an autoantibody to a protease enzyme responsible for cleaving von Willebrand factor?
- Thrombotic thrombocytopenic purpura (TTP) (correct)
- Disseminated intravascular coagulation
- Heparin-induced thrombocytopenia (HIT)
- Primary hemostasis (Platelet plug formation)
Which test is sensitive to factors I, II, VII, V, and X?
Which test is sensitive to factors I, II, VII, V, and X?
- Prolonged Prothrombin Time (PT)
- APTT
- Partial Thromboplastin Time (PTT)
- PT/INR (correct)
What does a prolonged prothrombin time indicate?
What does a prolonged prothrombin time indicate?
Which condition is due to a deficiency of coagulation factor VIII?
Which condition is due to a deficiency of coagulation factor VIII?
What is the target INR range for patients taking warfarin?
What is the target INR range for patients taking warfarin?
What is the antidote for warfarin?
What is the antidote for warfarin?
Which anticoagulant does not require laboratory monitoring?
Which anticoagulant does not require laboratory monitoring?
'Thrombotic thrombocytopenic purpura (TTP)' can result in which of the following?
'Thrombotic thrombocytopenic purpura (TTP)' can result in which of the following?
'Disseminated intravascular coagulation' usually occurs as a result of catastrophic activation of which pathway?
'Disseminated intravascular coagulation' usually occurs as a result of catastrophic activation of which pathway?
Which factor is a common cause of acquired platelet dysfunction?
Which factor is a common cause of acquired platelet dysfunction?
What happens as a result of local vasoconstriction following an injury to blood vessels?
What happens as a result of local vasoconstriction following an injury to blood vessels?
Which type of platelet disorder can be caused by decreased production of platelets due to suppression or failure of the bone marrow?
Which type of platelet disorder can be caused by decreased production of platelets due to suppression or failure of the bone marrow?
What is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
What is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
In which age group does idiopathic thrombocytopenic purpura (ITP) often present insidiously in adults?
In which age group does idiopathic thrombocytopenic purpura (ITP) often present insidiously in adults?
Which of the following is a rare complication of blood transfusion?
Which of the following is a rare complication of blood transfusion?
What type of autoantibody is usually produced in idiopathic thrombocytopenic purpura (ITP)?
What type of autoantibody is usually produced in idiopathic thrombocytopenic purpura (ITP)?
Which disorder is the commonest cause of thrombocytopenia due to decreased production of platelets?
Which disorder is the commonest cause of thrombocytopenia due to decreased production of platelets?
What is the commonest cause of thrombocytopenia due to increased platelet consumption?
What is the commonest cause of thrombocytopenia due to increased platelet consumption?
Which condition often follows a viral infection in children and presents with acute onset of thrombocytopenia?
Which condition often follows a viral infection in children and presents with acute onset of thrombocytopenia?
Which disorder presents with an insidious onset, most frequently in women aged 15-50 years, and can be associated with other autoimmune diseases?
Which disorder presents with an insidious onset, most frequently in women aged 15-50 years, and can be associated with other autoimmune diseases?
