21 Questions
Which of the following is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
Idiopathic thrombocytopenic purpura (ITP)
Which disorder often presents insidiously in adults, frequently in women aged 15-50 years, and can be associated with other autoimmune diseases?
Idiopathic thrombocytopenic purpura (ITP)
What is the commonest cause of thrombocytopenia due to decreased production of platelets?
aplastic anaemia
Which condition is a rare complication of blood transfusion?
Post-transfusion purpura (PTP)
In children, which disorder often has a more acute onset and often follows a viral infection?
Idiopathic thrombocytopenic purpura (ITP)
Which disorder is usually associated with an autoantibody produced that is usually IgG, directed against antigens on the platelet membrane?
Idiopathic thrombocytopenic purpura (ITP)
Which factor may lead to increased platelet consumption due to non-immune mechanisms?
viral infection
Which condition is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia in adults?
Idiopathic thrombocytopenic purpura (ITP)
Which condition is a relatively common disorder and is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
Idiopathic thrombocytopenic purpura (ITP)
What is the rare complication of blood transfusion?
Post-transfusion purpura (PTP)
Which disorder often presents insidiously, most frequently in women aged 15-50 years and can be associated with other autoimmune diseases?
Idiopathic thrombocytopenic purpura (ITP)
Which of the following is the most common cause of acquired platelet dysfunction?
Aspirin
Which condition is characterized by severe thrombocytopenia, fever, fluctuating neurological signs, and renal impairment?
Thrombotic thrombocytopenic purpura (TTP)
Which of the following tests measures the integrity of the intrinsic system and common clotting pathways?
Activated Partial Thromboplastin Time (APTT)
In which condition is an abnormal pattern of von Willebrand multimers highly likely to be demonstrated?
Thrombotic thrombocytopenic purpura (TTP)
What is the antidote for warfarin?
Vitamin K
What is the target range for International Normalized Ratio (INR) in patients taking warfarin?
2.0 - 3.0
Which factor deficiency can lead to a prolonged Prothrombin Time (PT)?
Factor II (Prothrombin)
What is the main mechanism of action of Direct Oral Anticoagulants (DOACs)?
Inhibition of factor Xa
Which factor deficiency is associated with Hemophilia A?
Factor VIII
What are the advantages of Direct Oral Anticoagulants (DOACs) over vitamin K antagonists?
No need for laboratory monitoring, less interference from diet and drugs, low risk of bleeding
Study Notes
Thrombocytopenia
- Isolated thrombocytopenia without anaemia or neutropenia is most frequently caused by Immune Thrombocytopenia (ITP).
- ITP often presents insidiously in adults, frequently in women aged 15-50 years, and can be associated with other autoimmune diseases.
Causes of Thrombocytopenia
- Decreased platelet production is most commonly caused by Aplastic Anaemia.
- Blood transfusion can lead to a rare complication causing thrombocytopenia.
- In children, ITP often has a more acute onset and often follows a viral infection.
Autoimmune Disorders
- ITP is usually associated with an autoantibody produced that is usually IgG, directed against antigens on the platelet membrane.
Platelet Consumption
- Increased platelet consumption due to non-immune mechanisms can be caused by Disseminated Intravascular Coagulation (DIC).
Bleeding Disorders
- Thrombotic Thrombocytopenic Purpura (TTP) is characterized by severe thrombocytopenia, fever, fluctuating neurological signs, and renal impairment.
Coagulation Tests
- The Partial Thromboplastin Time (PTT) measures the integrity of the intrinsic system and common clotting pathways.
- An abnormal pattern of von Willebrand multimers is highly likely to be demonstrated in von Willebrand Disease.
Anticoagulant Therapy
- The antidote for warfarin is Vitamin K.
- The target range for International Normalized Ratio (INR) in patients taking warfarin is 2.0-3.0.
- Factor VII deficiency can lead to a prolonged Prothrombin Time (PT).
Direct Oral Anticoagulants (DOACs)
- The main mechanism of action of DOACs is by directly inhibiting thrombin or factor Xa.
- Hemophilia A is associated with Factor VIII deficiency.
- The advantages of DOACs over vitamin K antagonists include rapid onset of action, fewer drug interactions, and no need for frequent INR monitoring.
Test your knowledge of congenital and acquired platelet disorders affecting production and function. Explore the causes, symptoms, and impact of abnormalities on bleeding. This quiz covers topics like thrombocytopenia, aplastic anemia, leukemia, bone marrow suppression, and drug-induced platelet abnormalities.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
