Podcast
Questions and Answers
Which of the following is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
Which of the following is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
- aplastic anaemia
- marrow infiltration
- leukaemia
- Idiopathic thrombocytopenic purpura (ITP) (correct)
Which disorder often presents insidiously in adults, frequently in women aged 15-50 years, and can be associated with other autoimmune diseases?
Which disorder often presents insidiously in adults, frequently in women aged 15-50 years, and can be associated with other autoimmune diseases?
- aplastic anaemia
- leukaemia
- Post-transfusion purpura (PTP)
- Idiopathic thrombocytopenic purpura (ITP) (correct)
What is the commonest cause of thrombocytopenia due to decreased production of platelets?
What is the commonest cause of thrombocytopenia due to decreased production of platelets?
- after chemotherapy
- leukaemia
- aplastic anaemia (correct)
- marrow infiltration
Which condition is a rare complication of blood transfusion?
Which condition is a rare complication of blood transfusion?
In children, which disorder often has a more acute onset and often follows a viral infection?
In children, which disorder often has a more acute onset and often follows a viral infection?
Which disorder is usually associated with an autoantibody produced that is usually IgG, directed against antigens on the platelet membrane?
Which disorder is usually associated with an autoantibody produced that is usually IgG, directed against antigens on the platelet membrane?
Which factor may lead to increased platelet consumption due to non-immune mechanisms?
Which factor may lead to increased platelet consumption due to non-immune mechanisms?
Which condition is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia in adults?
Which condition is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia in adults?
Which condition is a relatively common disorder and is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
Which condition is a relatively common disorder and is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
What is the rare complication of blood transfusion?
What is the rare complication of blood transfusion?
Which disorder often presents insidiously, most frequently in women aged 15-50 years and can be associated with other autoimmune diseases?
Which disorder often presents insidiously, most frequently in women aged 15-50 years and can be associated with other autoimmune diseases?
Which of the following is the most common cause of acquired platelet dysfunction?
Which of the following is the most common cause of acquired platelet dysfunction?
Which condition is characterized by severe thrombocytopenia, fever, fluctuating neurological signs, and renal impairment?
Which condition is characterized by severe thrombocytopenia, fever, fluctuating neurological signs, and renal impairment?
Which of the following tests measures the integrity of the intrinsic system and common clotting pathways?
Which of the following tests measures the integrity of the intrinsic system and common clotting pathways?
In which condition is an abnormal pattern of von Willebrand multimers highly likely to be demonstrated?
In which condition is an abnormal pattern of von Willebrand multimers highly likely to be demonstrated?
What is the antidote for warfarin?
What is the antidote for warfarin?
What is the target range for International Normalized Ratio (INR) in patients taking warfarin?
What is the target range for International Normalized Ratio (INR) in patients taking warfarin?
Which factor deficiency can lead to a prolonged Prothrombin Time (PT)?
Which factor deficiency can lead to a prolonged Prothrombin Time (PT)?
What is the main mechanism of action of Direct Oral Anticoagulants (DOACs)?
What is the main mechanism of action of Direct Oral Anticoagulants (DOACs)?
Which factor deficiency is associated with Hemophilia A?
Which factor deficiency is associated with Hemophilia A?
What are the advantages of Direct Oral Anticoagulants (DOACs) over vitamin K antagonists?
What are the advantages of Direct Oral Anticoagulants (DOACs) over vitamin K antagonists?
Flashcards
Idiopathic Thrombocytopenic Purpura (ITP)
Idiopathic Thrombocytopenic Purpura (ITP)
Autoimmune disorder causing isolated thrombocytopenia, often in women aged 15-50, sometimes post-viral infection.
Aplastic Anemia
Aplastic Anemia
Thrombocytopenia caused by reduced platelet production in the bone marrow.
Post-Transfusion Purpura (PTP)
Post-Transfusion Purpura (PTP)
Rare complication post-transfusion leading to thrombocytopenia.
Platelet Consumption (Non-Immune)
Platelet Consumption (Non-Immune)
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Aspirin-Induced Platelet Dysfunction
Aspirin-Induced Platelet Dysfunction
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Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic Thrombocytopenic Purpura (TTP)
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Activated Partial Thromboplastin Time (APTT)
Activated Partial Thromboplastin Time (APTT)
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von Willebrand Multimers (TTP)
von Willebrand Multimers (TTP)
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Vitamin K
Vitamin K
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INR Target (Warfarin)
INR Target (Warfarin)
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Factor II (Prothrombin) Deficiency
Factor II (Prothrombin) Deficiency
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Direct Oral Anticoagulants (DOACs)
Direct Oral Anticoagulants (DOACs)
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Factor VIII Deficiency
Factor VIII Deficiency
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DOAC Advantages
DOAC Advantages
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Study Notes
Thrombocytopenia
- Isolated thrombocytopenia without anaemia or neutropenia is most frequently caused by Immune Thrombocytopenia (ITP).
- ITP often presents insidiously in adults, frequently in women aged 15-50 years, and can be associated with other autoimmune diseases.
Causes of Thrombocytopenia
- Decreased platelet production is most commonly caused by Aplastic Anaemia.
- Blood transfusion can lead to a rare complication causing thrombocytopenia.
- In children, ITP often has a more acute onset and often follows a viral infection.
Autoimmune Disorders
- ITP is usually associated with an autoantibody produced that is usually IgG, directed against antigens on the platelet membrane.
Platelet Consumption
- Increased platelet consumption due to non-immune mechanisms can be caused by Disseminated Intravascular Coagulation (DIC).
Bleeding Disorders
- Thrombotic Thrombocytopenic Purpura (TTP) is characterized by severe thrombocytopenia, fever, fluctuating neurological signs, and renal impairment.
Coagulation Tests
- The Partial Thromboplastin Time (PTT) measures the integrity of the intrinsic system and common clotting pathways.
- An abnormal pattern of von Willebrand multimers is highly likely to be demonstrated in von Willebrand Disease.
Anticoagulant Therapy
- The antidote for warfarin is Vitamin K.
- The target range for International Normalized Ratio (INR) in patients taking warfarin is 2.0-3.0.
- Factor VII deficiency can lead to a prolonged Prothrombin Time (PT).
Direct Oral Anticoagulants (DOACs)
- The main mechanism of action of DOACs is by directly inhibiting thrombin or factor Xa.
- Hemophilia A is associated with Factor VIII deficiency.
- The advantages of DOACs over vitamin K antagonists include rapid onset of action, fewer drug interactions, and no need for frequent INR monitoring.
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