21 Questions
Which of the following is the most common cause of acquired platelet dysfunction?
Aspirin
What is the most likely cause of prolonged Prothrombin Time (PT) in a patient with liver disease?
Impaired synthesis of coagulation factors
Which coagulation factor deficiency is characteristic of haemophilia A?
Deficiency of factor VIII
What is responsible for the formation of platelet plug in primary hemostasis?
Platelet aggregation around exposed collagen
What is the cause of Heparin-Induced Thrombocytopenia (HIT)?
Formation of antibodies to heparin bound to platelet factor 4
What is the primary function of vasoconstriction in hemostasis?
To attract platelets to the site of injury
What enzyme converts fibrinogen into insoluble fibrin during clot formation?
Thrombin
Which disorder is characterized by fluctuating neurological signs and renal impairment?
Thrombotic Thrombocytopenic Purpura (TTP)
Which test is sensitive to factors I, II, VII, V, and X?
PT/INR
What is the cause of Disseminated Intravascular Coagulation(DIC)?
Catastrophic activation of the coagulation pathway due to sepsis
What is the antidote for warfarin?
Vitamin K
What does INR target value for warfarin therapy indicate?
Effectiveness and safety of anticoagulation
Which of the following is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?
Idiopathic thrombocytopenic purpura (ITP)
Which of the following is a relatively common disorder presenting insidiously in adults, most frequently in women aged 15-50 years?
Idiopathic thrombocytopenic purpura (ITP)
Which of the following platelet abnormalities often follows a viral infection in children?
Idiopathic thrombocytopenic purpura (ITP)
What is the commonest cause of thrombocytopenia due to decreased production of platelets?
Aplastic anaemia
Which disorder is associated with other autoimmune diseases, particularly systemic lupus erythematosus, and presents insidiously in adults?
Idiopathic thrombocytopenic purpura (ITP)
Which condition is a rare complication of blood transfusion?
Post-transfusion purpura (PTP)
In which disorder is the autoantibody produced usually IgG directed against antigens on the platelet membrane?
Idiopathic thrombocytopenic purpura (ITP)
What type of autoantibody is usually produced in idiopathic thrombocytopenic purpura (ITP)?
IgG
What is a rare complication of blood transfusion?
Post-transfusion purpura
Test your knowledge of congenital and acquired abnormalities of platelets, their impact on platelet production and function, and their association with bleeding problems. Explore conditions such as aplastic anaemia, leukaemia, marrow infiltration, and drug-induced thrombocytopenia.
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