Hematology 2: Platelet Disorders

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Questions and Answers

Which of the following is the most common cause of acquired platelet dysfunction?

  • Disseminated intravascular coagulation
  • Aspirin (correct)
  • Heparin
  • Thrombotic thrombocytopenic purpura

What is the most likely cause of prolonged Prothrombin Time (PT) in a patient with liver disease?

  • Excessive pooling of platelets in an enlarged spleen
  • Impaired synthesis of coagulation factors (correct)
  • Formation of autoantibodies against coagulation proteins
  • Increased consumption of coagulation factors

Which coagulation factor deficiency is characteristic of haemophilia A?

  • Deficiency of factor II
  • Deficiency of factor VIII (correct)
  • Deficiency of factor VII
  • Deficiency of factor IX

What is responsible for the formation of platelet plug in primary hemostasis?

<p>Platelet aggregation around exposed collagen (D)</p> Signup and view all the answers

What is the cause of Heparin-Induced Thrombocytopenia (HIT)?

<p>Formation of antibodies to heparin bound to platelet factor 4 (B)</p> Signup and view all the answers

What is the primary function of vasoconstriction in hemostasis?

<p>To attract platelets to the site of injury (A)</p> Signup and view all the answers

What enzyme converts fibrinogen into insoluble fibrin during clot formation?

<p>Thrombin (C)</p> Signup and view all the answers

Which disorder is characterized by fluctuating neurological signs and renal impairment?

<p>Thrombotic Thrombocytopenic Purpura (TTP) (C)</p> Signup and view all the answers

Which test is sensitive to factors I, II, VII, V, and X?

<p>PT/INR (A)</p> Signup and view all the answers

What is the cause of Disseminated Intravascular Coagulation(DIC)?

<p>Catastrophic activation of the coagulation pathway due to sepsis (C)</p> Signup and view all the answers

What is the antidote for warfarin?

<p>Vitamin K (A)</p> Signup and view all the answers

What does INR target value for warfarin therapy indicate?

<p>Effectiveness and safety of anticoagulation (B)</p> Signup and view all the answers

Which of the following is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?

<p>Idiopathic thrombocytopenic purpura (ITP) (A)</p> Signup and view all the answers

Which of the following is a relatively common disorder presenting insidiously in adults, most frequently in women aged 15-50 years?

<p>Idiopathic thrombocytopenic purpura (ITP) (A)</p> Signup and view all the answers

Which of the following platelet abnormalities often follows a viral infection in children?

<p>Idiopathic thrombocytopenic purpura (ITP) (B)</p> Signup and view all the answers

What is the commonest cause of thrombocytopenia due to decreased production of platelets?

<p>Aplastic anaemia (A)</p> Signup and view all the answers

Which disorder is associated with other autoimmune diseases, particularly systemic lupus erythematosus, and presents insidiously in adults?

<p>Idiopathic thrombocytopenic purpura (ITP) (B)</p> Signup and view all the answers

Which condition is a rare complication of blood transfusion?

<p>Post-transfusion purpura (PTP) (A)</p> Signup and view all the answers

In which disorder is the autoantibody produced usually IgG directed against antigens on the platelet membrane?

<p>Idiopathic thrombocytopenic purpura (ITP) (B)</p> Signup and view all the answers

What type of autoantibody is usually produced in idiopathic thrombocytopenic purpura (ITP)?

<p>IgG (D)</p> Signup and view all the answers

What is a rare complication of blood transfusion?

<p>Post-transfusion purpura (C)</p> Signup and view all the answers

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