Hematology 2: Platelet Disorders
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Questions and Answers

Which of the following is the most common cause of acquired platelet dysfunction?

  • Disseminated intravascular coagulation
  • Aspirin (correct)
  • Heparin
  • Thrombotic thrombocytopenic purpura
  • What is the most likely cause of prolonged Prothrombin Time (PT) in a patient with liver disease?

  • Excessive pooling of platelets in an enlarged spleen
  • Impaired synthesis of coagulation factors (correct)
  • Formation of autoantibodies against coagulation proteins
  • Increased consumption of coagulation factors
  • Which coagulation factor deficiency is characteristic of haemophilia A?

  • Deficiency of factor II
  • Deficiency of factor VIII (correct)
  • Deficiency of factor VII
  • Deficiency of factor IX
  • What is responsible for the formation of platelet plug in primary hemostasis?

    <p>Platelet aggregation around exposed collagen</p> Signup and view all the answers

    What is the cause of Heparin-Induced Thrombocytopenia (HIT)?

    <p>Formation of antibodies to heparin bound to platelet factor 4</p> Signup and view all the answers

    What is the primary function of vasoconstriction in hemostasis?

    <p>To attract platelets to the site of injury</p> Signup and view all the answers

    What enzyme converts fibrinogen into insoluble fibrin during clot formation?

    <p>Thrombin</p> Signup and view all the answers

    Which disorder is characterized by fluctuating neurological signs and renal impairment?

    <p>Thrombotic Thrombocytopenic Purpura (TTP)</p> Signup and view all the answers

    Which test is sensitive to factors I, II, VII, V, and X?

    <p>PT/INR</p> Signup and view all the answers

    What is the cause of Disseminated Intravascular Coagulation(DIC)?

    <p>Catastrophic activation of the coagulation pathway due to sepsis</p> Signup and view all the answers

    What is the antidote for warfarin?

    <p>Vitamin K</p> Signup and view all the answers

    What does INR target value for warfarin therapy indicate?

    <p>Effectiveness and safety of anticoagulation</p> Signup and view all the answers

    Which of the following is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia?

    <p>Idiopathic thrombocytopenic purpura (ITP)</p> Signup and view all the answers

    Which of the following is a relatively common disorder presenting insidiously in adults, most frequently in women aged 15-50 years?

    <p>Idiopathic thrombocytopenic purpura (ITP)</p> Signup and view all the answers

    Which of the following platelet abnormalities often follows a viral infection in children?

    <p>Idiopathic thrombocytopenic purpura (ITP)</p> Signup and view all the answers

    What is the commonest cause of thrombocytopenia due to decreased production of platelets?

    <p>Aplastic anaemia</p> Signup and view all the answers

    Which disorder is associated with other autoimmune diseases, particularly systemic lupus erythematosus, and presents insidiously in adults?

    <p>Idiopathic thrombocytopenic purpura (ITP)</p> Signup and view all the answers

    Which condition is a rare complication of blood transfusion?

    <p>Post-transfusion purpura (PTP)</p> Signup and view all the answers

    In which disorder is the autoantibody produced usually IgG directed against antigens on the platelet membrane?

    <p>Idiopathic thrombocytopenic purpura (ITP)</p> Signup and view all the answers

    What type of autoantibody is usually produced in idiopathic thrombocytopenic purpura (ITP)?

    <p>IgG</p> Signup and view all the answers

    What is a rare complication of blood transfusion?

    <p>Post-transfusion purpura</p> Signup and view all the answers

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