Podcast
Questions and Answers
What is the primary function of the periderm layer during embryonic development?
What is the primary function of the periderm layer during embryonic development?
- To provide a protective barrier against amniotic fluid (correct)
- To allow for the proliferation of basal cells
- To facilitate the differentiation of spinous cells
- To induce the formation of hair placodes
What is the role of Notch signaling in the differentiation of spinous cells?
What is the role of Notch signaling in the differentiation of spinous cells?
- Notch signaling directs spinous cells to continue differentiating and migrate towards the surface of the skin (correct)
- Notch signaling is responsible for the formation of hair placodes
- Notch signaling is required for the proliferation of basal cells
- Notch signaling induces the expression of K1 in spinous cells
Which of the following cell types is NOT found in the intermediate layer of the embryonic skin?
Which of the following cell types is NOT found in the intermediate layer of the embryonic skin?
- Undifferentiated cells
- Proliferating basal cells
- Cornified cells (correct)
- Spinous cells
Which of the following is a unique property of the basal layer of the epidermis?
Which of the following is a unique property of the basal layer of the epidermis?
What is the primary function of the hair placodes that form in the underlying dermis?
What is the primary function of the hair placodes that form in the underlying dermis?
Which of the following cell types is responsible for the formation of the granular layer and cornified layer of the epidermis?
Which of the following cell types is responsible for the formation of the granular layer and cornified layer of the epidermis?
Which layer of the hair follicle is heavily keratinized and has a fish-scale appearance?
Which layer of the hair follicle is heavily keratinized and has a fish-scale appearance?
Which layer of the hair follicle is pigmented and non-keratinized?
Which layer of the hair follicle is pigmented and non-keratinized?
Which cells in the hair follicle produce the cortex of the hair shaft?
Which cells in the hair follicle produce the cortex of the hair shaft?
During which phase of the hair growth cycle does the hair shaft exit the follicle?
During which phase of the hair growth cycle does the hair shaft exit the follicle?
Which structure in the hair follicle contains capillaries and is covered by cells that form the hair root and develop into the hair shaft?
Which structure in the hair follicle contains capillaries and is covered by cells that form the hair root and develop into the hair shaft?
During which phase of the hair growth cycle does cell division cease in the bulb, the papilla shrinks, and the shaft and inner root sheath detach from the dermal papilla?
During which phase of the hair growth cycle does cell division cease in the bulb, the papilla shrinks, and the shaft and inner root sheath detach from the dermal papilla?
Which of the following statements accurately describes the relationship between the external root sheath and the epidermis?
Which of the following statements accurately describes the relationship between the external root sheath and the epidermis?
At what level do the cells of the internal root sheath disappear?
At what level do the cells of the internal root sheath disappear?
Which of the following statements accurately describes the origin and insertion of the arrector pili muscle?
Which of the following statements accurately describes the origin and insertion of the arrector pili muscle?
Which of the following statements accurately describes the development of the epidermis?
Which of the following statements accurately describes the development of the epidermis?
Which of the following statements accurately describes the function of the basement membrane in the development of the epidermis?
Which of the following statements accurately describes the function of the basement membrane in the development of the epidermis?
Which of the following statements accurately describes the attachment of basal cells to the basement membrane?
Which of the following statements accurately describes the attachment of basal cells to the basement membrane?
What marks the transition from stage 4 to stage 5 of hair follicle development?
What marks the transition from stage 4 to stage 5 of hair follicle development?
Which stage is characterized by the formation of a spherical dermal papilla adjacent to the hair peg?
Which stage is characterized by the formation of a spherical dermal papilla adjacent to the hair peg?
At which stage does the hair shaft begin to form at the upper end of the hair follicle?
At which stage does the hair shaft begin to form at the upper end of the hair follicle?
During which stage does the dermal papilla become fully enclosed?
During which stage does the dermal papilla become fully enclosed?
What happens to the hair shaft in stage 7 of hair follicle development?
What happens to the hair shaft in stage 7 of hair follicle development?
Which stage involves the elongation of the inner root sheath up the hair follicle?
Which stage involves the elongation of the inner root sheath up the hair follicle?
Which layer of the epidermis is responsible for the production of melanin?
Which layer of the epidermis is responsible for the production of melanin?
What is the primary function of the stratum lucidum layer?
What is the primary function of the stratum lucidum layer?
Which layer of the epidermis contains Langerhans' cells, which play a role in the immune response?
Which layer of the epidermis contains Langerhans' cells, which play a role in the immune response?
What is the characteristic appearance of cells in the stratum spinosum layer under a light microscope?
What is the characteristic appearance of cells in the stratum spinosum layer under a light microscope?
Which layer of the epidermis contains the stem cells responsible for cell division and renewal?
Which layer of the epidermis contains the stem cells responsible for cell division and renewal?
Which division of the brachial plexus trunks is responsible for innervating the muscles of the anterior compartment of the arm and forearm?
Which division of the brachial plexus trunks is responsible for innervating the muscles of the anterior compartment of the arm and forearm?
What is the primary function of Merkel cells in the epidermis?
What is the primary function of Merkel cells in the epidermis?
Which of the following structures does the brachial plexus NOT form?
Which of the following structures does the brachial plexus NOT form?
Which part of the brachial plexus is responsible for providing sympathetic innervation?
Which part of the brachial plexus is responsible for providing sympathetic innervation?
Which cord of the brachial plexus is formed by the union of the anterior divisions of the superior and middle trunks?
Which cord of the brachial plexus is formed by the union of the anterior divisions of the superior and middle trunks?
Which muscle(s) are innervated by the posterior divisions of the brachial plexus trunks?
Which muscle(s) are innervated by the posterior divisions of the brachial plexus trunks?
Which of the following disorders is NOT typically associated with damage to the brachial plexus?
Which of the following disorders is NOT typically associated with damage to the brachial plexus?
Which nerve innervates the pectoralis major but also sends a loop to the medial pectoral nerve that innervates the pectoralis minor?
Which nerve innervates the pectoralis major but also sends a loop to the medial pectoral nerve that innervates the pectoralis minor?
Which branch of the posterior cord receives fibers from C5 and C6 and innervates the superior portion of the subscapularis muscle?
Which branch of the posterior cord receives fibers from C5 and C6 and innervates the superior portion of the subscapularis muscle?
Which terminal branch of the posterior cord innervates the teres minor and deltoid muscles, as well as the glenohumeral joint and skin over the inferior part of the deltoid?
Which terminal branch of the posterior cord innervates the teres minor and deltoid muscles, as well as the glenohumeral joint and skin over the inferior part of the deltoid?
Which nerve emerges from both the medial and lateral cords and supplies all flexors of the forearm except for the flexor carpi ulnaris and the medial half of the flexor digitorum profundus?
Which nerve emerges from both the medial and lateral cords and supplies all flexors of the forearm except for the flexor carpi ulnaris and the medial half of the flexor digitorum profundus?
Which branch of the brachial plexus can lead to an 'Ape Hand' deformity when injured?
Which branch of the brachial plexus can lead to an 'Ape Hand' deformity when injured?
The hand of benediction deformity is associated with damage to which nerve?
The hand of benediction deformity is associated with damage to which nerve?
Which nerve supplies most of the intrinsic muscles of the hand including the hypothenar eminence, and skin on the medial side of the hand?
Which nerve supplies most of the intrinsic muscles of the hand including the hypothenar eminence, and skin on the medial side of the hand?
Injury to which nerve results in 'wrist drop'?
Injury to which nerve results in 'wrist drop'?
Which nerve supplies the biceps, coracobrachialis, and brachialis muscles?
Which nerve supplies the biceps, coracobrachialis, and brachialis muscles?
Ape Hand deformity is associated with the compression of which nerve?
Ape Hand deformity is associated with the compression of which nerve?
Waiter's tip deformity is characteristic of injury to which part of the brachial plexus?
Waiter's tip deformity is characteristic of injury to which part of the brachial plexus?
'Claw Hand' deformity is a result of injury to which nerve?
'Claw Hand' deformity is a result of injury to which nerve?
Which of the following muscles are innervated by the lateral cord of the brachial plexus?
Which of the following muscles are innervated by the lateral cord of the brachial plexus?
Which nerve root compression is associated with the condition known as 'Klumpke's palsy'?
Which nerve root compression is associated with the condition known as 'Klumpke's palsy'?
Which of the following muscles is innervated by the posterior cord of the brachial plexus?
Which of the following muscles is innervated by the posterior cord of the brachial plexus?
Which of the following conditions is NOT typically associated with brachial plexus injury?
Which of the following conditions is NOT typically associated with brachial plexus injury?
Which nerve root compression is associated with the condition known as 'Erb's palsy'?
Which nerve root compression is associated with the condition known as 'Erb's palsy'?
Which of the following muscles is innervated by the medial cord of the brachial plexus?
Which of the following muscles is innervated by the medial cord of the brachial plexus?
Which of the following muscles is innervated by the dorsal scapular nerve?
Which of the following muscles is innervated by the dorsal scapular nerve?
A patient presents with winging of the scapula, which is indicative of a lesion involving which nerve?
A patient presents with winging of the scapula, which is indicative of a lesion involving which nerve?
Which of the following muscles is innervated by the nerve to subclavius?
Which of the following muscles is innervated by the nerve to subclavius?
A patient complains of dull, aching pain in the posterior shoulder region, which may indicate a lesion involving which nerve?
A patient complains of dull, aching pain in the posterior shoulder region, which may indicate a lesion involving which nerve?
Which of the following muscles is responsible for abduction of the arm at the shoulder joint?
Which of the following muscles is responsible for abduction of the arm at the shoulder joint?
A lesion involving which nerve may lead to difficulty in protraction of the scapula during arm elevation?
A lesion involving which nerve may lead to difficulty in protraction of the scapula during arm elevation?
Which nerve is responsible for innervating the majority of the intrinsic muscles of the hand, including the thenar eminence, as well as the skin on the medial side of the hand?
Which nerve is responsible for innervating the majority of the intrinsic muscles of the hand, including the thenar eminence, as well as the skin on the medial side of the hand?
Which nerve branch of the brachial plexus is responsible for innervating the pectoralis major muscle, but also sends a communicating loop to the medial pectoral nerve that supplies the pectoralis minor muscle?
Which nerve branch of the brachial plexus is responsible for innervating the pectoralis major muscle, but also sends a communicating loop to the medial pectoral nerve that supplies the pectoralis minor muscle?
Which of the following conditions is characterized by the 'ape hand' deformity, resulting from damage to a specific nerve?
Which of the following conditions is characterized by the 'ape hand' deformity, resulting from damage to a specific nerve?
Which nerve branch of the brachial plexus is responsible for innervating the triceps brachii, anconeus, brachioradialis, and extensor muscles of the forearm, as well as providing cutaneous innervation to the posterior aspect of the arm and forearm?
Which nerve branch of the brachial plexus is responsible for innervating the triceps brachii, anconeus, brachioradialis, and extensor muscles of the forearm, as well as providing cutaneous innervation to the posterior aspect of the arm and forearm?
Injury to which nerve of the brachial plexus is associated with the characteristic 'winging of the scapula' deformity?
Injury to which nerve of the brachial plexus is associated with the characteristic 'winging of the scapula' deformity?
Which nerve of the brachial plexus is responsible for providing sympathetic innervation?
Which nerve of the brachial plexus is responsible for providing sympathetic innervation?
Which nerve supplies most of the intrinsic muscles of the hand including the hypothenar eminence, and skin on the medial side of the hand?
Which nerve supplies most of the intrinsic muscles of the hand including the hypothenar eminence, and skin on the medial side of the hand?
Which nerve supplies the deltoid and teres minor muscles?
Which nerve supplies the deltoid and teres minor muscles?
Injury to which nerve results in 'wrist drop'?
Injury to which nerve results in 'wrist drop'?
Which brachial plexus injury results in 'Waiter’s tip deformity'?
Which brachial plexus injury results in 'Waiter’s tip deformity'?
Which nerve supplies the biceps, coracobrachialis, and brachialis muscles?
Which nerve supplies the biceps, coracobrachialis, and brachialis muscles?
'Ape Hand' deformity is associated with injury to which nerve?
'Ape Hand' deformity is associated with injury to which nerve?
Which of the following muscles is innervated by the axillary nerve, a terminal branch of the posterior cord?
Which of the following muscles is innervated by the axillary nerve, a terminal branch of the posterior cord?
Injury to which nerve can result in the 'waiter's tip' deformity, characterized by the inability to extend the wrist and fingers?
Injury to which nerve can result in the 'waiter's tip' deformity, characterized by the inability to extend the wrist and fingers?
Which of the following muscles is supplied by the thoracodorsal nerve, a branch of the posterior cord?
Which of the following muscles is supplied by the thoracodorsal nerve, a branch of the posterior cord?
Which condition is associated with the compression of the C8 and T1 nerve roots, resulting in paralysis of the intrinsic muscles of the hand?
Which condition is associated with the compression of the C8 and T1 nerve roots, resulting in paralysis of the intrinsic muscles of the hand?
Which of the following muscles is innervated by the medial pectoral nerve, a branch of the medial cord?
Which of the following muscles is innervated by the medial pectoral nerve, a branch of the medial cord?
Injury to which nerve can result in the 'ape hand' deformity, characterized by the inability to abduct and oppose the thumb?
Injury to which nerve can result in the 'ape hand' deformity, characterized by the inability to abduct and oppose the thumb?
Which nerve is responsible for innervating the three thenar muscles, leading to atrophy known as 'ape hand' when damaged?
Which nerve is responsible for innervating the three thenar muscles, leading to atrophy known as 'ape hand' when damaged?
Which nerve emerges from both the medial and lateral cords of the brachial plexus and supplies all flexors of the forearm except for the flexor carpi ulnaris and the medial half of the flexor digitorum profundus?
Which nerve emerges from both the medial and lateral cords of the brachial plexus and supplies all flexors of the forearm except for the flexor carpi ulnaris and the medial half of the flexor digitorum profundus?
Which brachial plexus nerve branch can result in an 'Ape Hand' deformity when injured?
Which brachial plexus nerve branch can result in an 'Ape Hand' deformity when injured?
Which part of the brachial plexus is responsible for providing sympathetic innervation?
Which part of the brachial plexus is responsible for providing sympathetic innervation?
Which nerve root compression is associated with 'Erb's palsy,' a condition that affects the shoulder and arm muscles?
Which nerve root compression is associated with 'Erb's palsy,' a condition that affects the shoulder and arm muscles?
Which of the following conditions is NOT typically associated with brachial plexus injury?
Which of the following conditions is NOT typically associated with brachial plexus injury?
Which of the following nerves innervates the rhomboid muscles?
Which of the following nerves innervates the rhomboid muscles?
Injury to which nerve can lead to the 'winged scapula' deformity?
Injury to which nerve can lead to the 'winged scapula' deformity?
Which nerve innervates the supraspinatus and infraspinatus muscles, as well as the glenohumeral (shoulder) joint?
Which nerve innervates the supraspinatus and infraspinatus muscles, as well as the glenohumeral (shoulder) joint?
Which nerve innervates the subclavius muscle and the sternoclavicular joint?
Which nerve innervates the subclavius muscle and the sternoclavicular joint?
Injury to which nerve can cause an 'Ape Hand' deformity?
Injury to which nerve can cause an 'Ape Hand' deformity?
Which of the following nerves innervates the serratus anterior muscle?
Which of the following nerves innervates the serratus anterior muscle?
Which nerve branch of the brachial plexus is responsible for innervating the superior portion of the subscapularis muscle?
Which nerve branch of the brachial plexus is responsible for innervating the superior portion of the subscapularis muscle?
Which of the following statements about the upper subscapular nerve is correct?
Which of the following statements about the upper subscapular nerve is correct?
Injury to which nerve branch of the brachial plexus can result in winging of the scapula?
Injury to which nerve branch of the brachial plexus can result in winging of the scapula?
Which muscle is primarily innervated by the upper subscapular nerve?
Which muscle is primarily innervated by the upper subscapular nerve?
Where does the upper subscapular nerve originate from within the brachial plexus?
Where does the upper subscapular nerve originate from within the brachial plexus?
Which of the following statements about the upper subscapular nerve is false?
Which of the following statements about the upper subscapular nerve is false?
Which nerve is responsible for innervating the supraspinatus, infraspinatus, and glenohumeral (shoulder) joint?
Which nerve is responsible for innervating the supraspinatus, infraspinatus, and glenohumeral (shoulder) joint?
What is the course of the suprascapular nerve?
What is the course of the suprascapular nerve?
Which nerve arises from the anterior rami of C5-C7 and innervates the serratus anterior muscle?
Which nerve arises from the anterior rami of C5-C7 and innervates the serratus anterior muscle?
Which nerve arises from the superior trunk receiving fibers from C5, C6, and often C4, and innervates the subclavius muscle and sternoclavicular joint?
Which nerve arises from the superior trunk receiving fibers from C5, C6, and often C4, and innervates the subclavius muscle and sternoclavicular joint?
Which nerve arises from the anterior ramus of C5 with a frequent contribution from C4, pierces the middle scalene, descends deep to the levator scapulae, and innervates the rhomboid muscles?
Which nerve arises from the anterior ramus of C5 with a frequent contribution from C4, pierces the middle scalene, descends deep to the levator scapulae, and innervates the rhomboid muscles?
Which nerve is responsible for innervating the supraspinatus muscle and the glenohumeral (shoulder) joint, but not the infraspinatus muscle?
Which nerve is responsible for innervating the supraspinatus muscle and the glenohumeral (shoulder) joint, but not the infraspinatus muscle?
Which nerve supplies the superior portion of the subscapularis muscle?
Which nerve supplies the superior portion of the subscapularis muscle?
Which nerve passes posteriorly and enters the subscapularis muscle?
Which nerve passes posteriorly and enters the subscapularis muscle?
Which nerve innervates the inferior portion of the subscapularis muscle and the teres major muscle?
Which nerve innervates the inferior portion of the subscapularis muscle and the teres major muscle?
Which nerve supplies the teres minor and deltoid muscles?
Which nerve supplies the teres minor and deltoid muscles?
Which nerve receives fibers from C5 and C6 and runs inferolaterally to innervate latissimus dorsi?
Which nerve receives fibers from C5 and C6 and runs inferolaterally to innervate latissimus dorsi?
Which nerve descends posteriorly to innervate triceps brachii and anconeus?
Which nerve descends posteriorly to innervate triceps brachii and anconeus?
Which nerve originates from both the medial and lateral cords and supplies all flexors of the forearm except for flexor carpi ulnaris?
Which nerve originates from both the medial and lateral cords and supplies all flexors of the forearm except for flexor carpi ulnaris?
'Hand of Benediction' deformity is associated with damage to which nerve?
'Hand of Benediction' deformity is associated with damage to which nerve?
Study Notes
Embryonic Skin Development
- The periderm layer serves as a protective covering during early embryonic development.
- Notch signaling is pivotal in the differentiation of spinous cells, influencing their maturation.
- The intermediate layer of embryonic skin does not contain keratinocytes; it consists mainly of peridermal and spinous cells.
- Unique to the basal layer of the epidermis is its ability to continuously divide and renew itself.
- Hair placodes in the dermis are essential for initiating hair follicle formation and guiding hair development.
- Keratinocytes are responsible for forming the granular layer and cornified layer of the epidermis.
- The outer root sheath of the hair follicle features a heavily keratinized, fish-scale appearance.
- The inner root sheath is pigmented and non-keratinized, adding to the hair's structural integrity.
- The cortex of the hair shaft is formed by keratinocytes within the hair follicle.
- During the anagen phase, the hair shaft emerges from the follicle.
- The hair bulb contains capillaries and cells that develop into the hair shaft.
- Catagen phase involves reduced cell division within the bulb, leading to detachment from the dermal papilla.
- The external root sheath is derived from the epidermis, reflecting a close developmental relationship.
- Internal root sheath cells vanish at the upper part of the hair follicle.
- The arrector pili muscle originates from the dermal layer and inserts into the hair follicle, enabling hair to stand when cold or scared.
- Epidermis development involves a complex interaction of signaling pathways and cellular differentiation.
- The basement membrane plays a crucial role in epidermis structural support and cellular attachment.
- Basal cells anchor to the basement membrane through hemidesmosomes, maintaining epidermal integrity.
- Transition from stage 4 to 5 of hair follicle development is marked by interactions between the hair strand and dermal papilla.
- Stage 3 features the formation of a spherical dermal papilla near the hair peg.
- The hair shaft begins formation in stage 4 of hair follicle development.
- The dermal papilla becomes fully enclosed during stage 6.
- In stage 7, the hair shaft undergoes keratinization before forming a complete hair strand.
- The inner root sheath elongates upwards the follicle during its development stages.
- Melanocytes within the stratum basale are responsible for melanin production.
- The stratum lucidum layer primarily acts as a barrier to protect deeper skin layers.
- The stratum spinosum features Langerhans cells, integral to the immune response in the skin.
- Cells in the stratum spinosum appear spiky or "prickly" under a light microscope due to desmosomal connections.
- The basal layer of the epidermis is where stem cells for ongoing cell renewal reside.
Brachial Plexus and Related Conditions
- The lateral cord of the brachial plexus innervates muscles in the anterior arm and forearm.
- Merkel cells in the epidermis function as mechanoreceptors, detecting touch and pressure.
- The brachial plexus does not form the cranial nerves; it pertains to peripheral innervations.
- Sympathetic innervation arises from the sympathetic trunk and is linked to the brachial plexus.
- The posterior cord is formed by the combined anterior divisions of the brachial plexus trunks.
- Posterior divisions innervate muscles like the deltoid and teres minor.
- Conditions such as 'Ape Hand' result from median nerve injuries affecting thumb function.
- The hand of benediction deformity signifies ulnar nerve injury affecting finger extension.
- The ulnar nerve supplies the majority of hand's intrinsic muscles, influencing movements and sensation.
- Wrist drop is a symptom of radial nerve injury affecting wrist extension.
- The musculocutaneous nerve innervates biceps, coracobrachialis, and brachialis muscles.
- Injury to the median nerve is associated with 'Ape Hand' due to the paralysis of the thenar muscles.
- The waiter's tip deformity is linked to upper brachial plexus injury affecting deltoid muscle activation.
- The intrinsic muscles' paralysis from lower trunk compression leads to Klumpke's palsy, impacting hand function.
- The thoracodorsal nerve innervates the latissimus dorsi muscle.
- The long thoracic nerve innervates the serratus anterior, and its injury can lead to scapula winging.
- The upper subscapular nerve arises from the posterior cord and innervates the subscapularis muscle.
- Suprascapular nerve innervates both supraspinatus and infraspinatus muscles, critical for shoulder stability.
- A lesion affecting the dorsal scapular nerve can lead to scapula winging, impacting upper limb movement.
- The medial pectoral nerve is responsible for innervating pectoralis major and minor, contributing to shoulder function.
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Description
Test your knowledge on the anatomy of the hair follicle including the external and internal root sheath, hair shaft, glassy membrane, and more. Understand the relationships between the skin layers, arrector pili muscle, sebaceous, and sweat glands.